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2-(3-Cyanophenyl)-2,2-difluoroacetic+acid
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2-(3-Cyanophenyl)-2,2-difluoroacetic+acid
Artikel-Nr:
(BLDPBD01192877-250)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD01192877-250
Lokale Artikelnummer::
BLDPBD01192877-250
Beschreibung:
(11bR)-N-(2,6-Bis(4-methoxyphenyl)-4-oxido-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-1,1,1-trifluoromethanesulphonamide 97%
VE:
1 * 250 mg
Lieferant:
Sigma-Aldrich
Beschreibung:
Potassium ionophore III may be used to formulate the ion-selective poly(vinyl chloride) (PVC) membranes as a part of potentiometric sensors used in potentiometric electric tongue for food analysis.
Artikel-Nr:
(PRSI29-710)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-710
Lokale Artikelnummer::
PRSI29-710
Beschreibung:
ACP1 belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate.The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Three transcript variants encoding distinct isoforms have been identified for this gene.
VE:
1 * 100 µG
Artikel-Nr:
(1.09288.1000)
Lieferant:
Merck
Hersteller-Artikelnummer::
1.09288.1000
Lokale Artikelnummer::
MERC1.09288.1000
Beschreibung:
Kupfer(II)-ethylendiamin 1 mol/l (3 N) in wässriger Lösung für die Viskositätsmessung von Cellulose gemäß DIN 54270, Supelco®
VE:
1 * 1 L
Artikel-Nr:
(BOSSBS-3390R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3390R-CY3
Lokale Artikelnummer::
BOSSBS-3390R-CY3
Beschreibung:
Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3494R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3494R-CY5
Lokale Artikelnummer::
BOSSBS-3494R-CY5
Beschreibung:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1.
VE:
1 * 100 µl
Lieferant:
VWR Chemicals
Beschreibung:
Xylenolorange Tetranatriumsalz, AnalaR NORMAPUR® ACS, Reag. Ph. Eur. Indikator für die Metalltitration
Artikel-Nr:
(20909-50MG-F)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
20909-50MG-F
Lokale Artikelnummer::
SUPL20909-50MG-F
Beschreibung:
Selective ionophore for cadmium used in solvent polymeric membranes.
VE:
1 * 50 mg
Artikel-Nr:
(BLDPBD01180286-1G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD01180286-1G
Lokale Artikelnummer::
BLDPBD01180286-1G
Beschreibung:
(3AS,3a'S,8aR,8a'R)-2,2'-(pentane-3,3-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole) ≥97%, ee 99%
VE:
1 * 1 g
Artikel-Nr:
(43340-50ML)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
43340-50ML
Lokale Artikelnummer::
SUPL43340-50ML
Beschreibung:
1,3-Diphenyltetramethyldisilazane, LiChropur™ zur GC-Derivatisierung, Supelco®
VE:
1 * 50 mL
Artikel-Nr:
(BLDPBD369713-100MG)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD369713-100MG
Lokale Artikelnummer::
BLDPBD369713-100MG
Beschreibung:
TC-E 5003 95%
VE:
1 * 100 mg
Artikel-Nr:
(BLDPBD01425339-250)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD01425339-250
Lokale Artikelnummer::
BLDPBD01425339-250
Beschreibung:
Iridium-(4,4'-difluoro-2,2'-bipyridine-κN1,κN1')bis[3,5-difluoro-2-(5-trifluoromethyl-2-pyridinyl-κN)phenyl-κC]-hexafluorophosphate 97%
VE:
1 * 250 mg
Artikel-Nr:
(BLDPBD01442482-100)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD01442482-100
Lokale Artikelnummer::
BLDPBD01442482-100
Beschreibung:
Iridium-(4,4'-dimethoxy-2,2'-bipyridine-κN1,κN1')bis[(3-fluoro-5-trifluoromethyl)-2-(5-trifluoromethyl-2-pyridinyl-κN)phenyl-κC]-hexafluorophosphate 97%
VE:
1 * 100 mg
Artikel-Nr:
(BOSSBS-3494R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3494R-A350
Lokale Artikelnummer::
BOSSBS-3494R-A350
Beschreibung:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3495R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3495R-A488
Lokale Artikelnummer::
BOSSBS-3495R-A488
Beschreibung:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3495R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3495R-CY5.5
Lokale Artikelnummer::
BOSSBS-3495R-CY5.5
Beschreibung:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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