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17-Octadecins\u00E4ure
Artikel-Nr:
(466-0703)
Lieferant:
Binder
Hersteller-Artikelnummer::
9010-0373
Lokale Artikelnummer::
BIND9010-0373
Beschreibung:
Die Avantgarde.Line-Geräte der M-Serie verfügen über eine maximale Temperatur von 300 °C und verschiedene erweiterte Programmieroptionen machen diese Materialprüfkammern ideal für Material- und Alterungstests. Die Geräte verfügen über einen hohen Luftdurchsatz und ihre leistungsstarken Ventilatoren sorgen für eine schnelle Erwärmung.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-1380R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1380R-A555
Lokale Artikelnummer::
BOSSBS-1380R-A555
Beschreibung:
G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilisation and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells.
VE:
1 * 100 µl
Artikel-Nr:
(613-6866)
Lieferant:
SOCOREX ISBA
Hersteller-Artikelnummer::
826.0020
Lokale Artikelnummer::
SOCO826.0020
Beschreibung:
Manuelle Einkanalpipetten mit optimiertem Form/Größe-Verhältnis für überlegene Handhabung und verbesserte Bewegungsabläufe bei der Arbeit mit Mikroröhrchen. Ideal für Forschungslabore.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-2734R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2734R-CY7
Lokale Artikelnummer::
BOSSBS-2734R-CY7
Beschreibung:
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2734R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2734R-CY3
Lokale Artikelnummer::
BOSSBS-2734R-CY3
Beschreibung:
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2734R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2734R-A680
Lokale Artikelnummer::
BOSSBS-2734R-A680
Beschreibung:
Transcriptional repressor mainly required for germinal centre (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
VE:
1 * 100 µl
Lieferant:
Hach
Beschreibung:
Diese einfache und kostengünstige Testmethode mit Farbscheibe zählt zu den genauesten visuellen Testsätzen zur pH-Wert-Bestimmung.
Lieferant:
MP Biomedicals
Beschreibung:
Dextran sulphate is a polyanionic derivative of dextran produced by esterification of dextran with chlorosulphonic acid. The sulphur content is approximately 17% which corresponds to an average of 1,9 sulphate groups per glucosyl residue of the dextran molecule. Dextran sulphate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry.
Lieferant:
Sigma-Aldrich
Beschreibung:
DL-Natriumlactat, Sigma-Aldrich®
Artikel-Nr:
(SIALL7900-100ML)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
L7900-100ML
Lokale Artikelnummer::
SIALL7900-100ML
Beschreibung:
DL-Natriumlactat, Sigma-Aldrich®
VE:
1 * 100 mL
Artikel-Nr:
(PRSI91-449)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-449
Lokale Artikelnummer::
PRSI91-449
Beschreibung:
Osteoactivin is an intracellular glycoprotein belongs to the NMB/pMEL-17 family, which is asscociated with cell endosomal/lysomal compartments. Human Osteoactivin is a 560 amino acid type I transmembrane protein, and one alternate splice form shows a 12 amino acid insert between amino acid 339-340. An additional 206 amino acid isoform shows a mutation at position 181 that results in a 26 amino acid substitution for the C-terminal 380 amino acids. Cells knowns to express Osteoactivin include fibroblast, osteoblasts, myeloid dendritic cell, melanocytes, plus fetal chondrocytes and stratum basale keratinocytes, macrophages/keratinocytes.
VE:
1 * 50 µG
Lieferant:
Sigma-Aldrich
Beschreibung:
Riboflavin-5'-phosphat Natriumsalz Dihydrat, Sigma-Aldrich®
Lieferant:
Sigma-Aldrich
Beschreibung:
Natriumthiosulfat Pentahydrat, Sigma-Aldrich®
Artikel-Nr:
(SIALF1392-25MG)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
F1392-25MG
Lokale Artikelnummer::
SIALF1392-25MG
Beschreibung:
Riboflavin-5'-phosphat Natriumsalz Dihydrat, Sigma-Aldrich®
VE:
1 * 25 mg
Lieferant:
Sigma-Aldrich
Beschreibung:
Cystaminiumdichlorid, Sigma-Aldrich®
Artikel-Nr:
(PRSI28-077)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-077
Lokale Artikelnummer::
PRSI28-077
Beschreibung:
HOXB7 belongs to the homeobox family. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXBThis gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.
VE:
1 * 100 µG
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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