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2,2\'-Dihydroxybiphenyl
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2,2\'-Dihydroxybiphenyl
Lieferant:
Thermo Scientific
Beschreibung:
3-Methoxysalicylsäure
Artikel-Nr:
(SCOT286256207)
Lieferant:
DWK Life Sciences
Hersteller-Artikelnummer::
286256207
Lokale Artikelnummer::
SCOT286256207
Beschreibung:
DURAN®, Borosilikatglas 3.3, klar.
VE:
1 * 50 ST
Lieferant:
FLUOROCHEM
Beschreibung:
Methyl-5-hydroxynicotinat
Artikel-Nr:
(FLUO018276-10G)
Lieferant:
FLUOROCHEM
Hersteller-Artikelnummer::
018276-10G
Lokale Artikelnummer::
FLUO018276-10G
Beschreibung:
1-Brom-2-ethylbenzol
VE:
1 * 10 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PROONIST-2143)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
NIST-2143
Lokale Artikelnummer::
PROONIST-2143
Beschreibung:
4-Fluorbenzoesäure
VE:
1 * 2 g
Lieferant:
BOCHEM
Beschreibung:
Edelstahl 18/10.
Lieferant:
FLUOROCHEM
Beschreibung:
Ethylioddifluoracetat
Lieferant:
TERUMO
Beschreibung:
Dieser intravenöse Katheter ist in drei Ausführungen erhältlich: Gerade (EFTE), mit Flügeln (FEP) sowie mit Flügeln und Einspritzanschluss (FEP).
Artikel-Nr:
(BOSSBS-12495R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12495R-CY7
Lokale Artikelnummer::
BOSSBS-12495R-CY7
Beschreibung:
APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8594R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8594R-A555
Lokale Artikelnummer::
BOSSBS-8594R-A555
Beschreibung:
Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD22 (ankyrin repeat domain 22) is a 191 amino acid protein that contains four ANK repeats. Conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, ANKRD22 is encoded by a gene that maps to human chromosome 10. Chromosome 10 encodes nearly 1,200 genes within 135 million bases, making up approximately 4.5% of the human genome. Several protein-coding genes, including those that encode for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12495R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12495R-CY3
Lokale Artikelnummer::
BOSSBS-12495R-CY3
Beschreibung:
APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12495R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12495R-CY5
Lokale Artikelnummer::
BOSSBS-12495R-CY5
Beschreibung:
APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13343R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13343R-A680
Lokale Artikelnummer::
BOSSBS-13343R-A680
Beschreibung:
The GGA family of proteins (Golgi-localized, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin (1?). Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) (1,2,4). GGAs have modular structures with an N-terminal VHS (VPS-27, Hrs, and STAM) domain followed by a GAT (GGA and TOM1) domain, a connecting hinge segment, and a C-terminal GAE (?adaptin ear) domain (5). The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences (3). GGA1 and GGA2 do not associate with each other, but they do colocalize on perinuclear membranes (2). The cytosolic domain of memapsin 2, but not that of memapsin 1, binds the VHS domains of GGA1 and GGA2 (6). The human GGA1 gene maps to chromosome 22 and encodes a protein that shares 45% sequence identity with GGA2 and GGA3 (1).
VE:
1 * 100 µl
Artikel-Nr:
(MOLEM71149744)
Lieferant:
Molekula
Hersteller-Artikelnummer::
M71149744
Lokale Artikelnummer::
MOLEM71149744
Beschreibung:
3,3-Dimethyl-1,5-dioxaspiro[5.5]undecan-9-on
VE:
1 * 25 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(HECH41001122)
Lieferant:
GLASWARENFABRIK KARL HECHT
Hersteller-Artikelnummer::
41001122
Lokale Artikelnummer::
HECH41001122
Beschreibung:
Borosilicate glass highly resistant cover glasses with precise and faultless cut.
VE:
1 * 1.000 ST
Artikel-Nr:
(MOLEM30726953)
Lieferant:
Molekula
Hersteller-Artikelnummer::
M30726953
Lokale Artikelnummer::
MOLEM30726953
Beschreibung:
Indigocarmin
VE:
1 * 25 g
This is a MarketSource item. Additional charges may apply
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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