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1,8-Diazabicyclo[5.4.0]-7-undecen
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1,8-Diazabicyclo[5.4.0]-7-undecen
Artikel-Nr:
(BOSSBS-9191R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9191R-A488
Lokale Artikelnummer::
BOSSBS-9191R-A488
Beschreibung:
PDZRN3 contains a RING-finger motif in its N-terminal region, two PDZ domains in its central region and a consensus-binding motif for PDZ domains at its C-terminus. It was identified in silico as a homolog of the protein known as LNX1 or SEMCAP1, which possesses ubiquitin ligase activity and binds the membrane protein Semaphorin 4C. However, PDZRN3 itself has not previously been characterized. We have now evaluated the properties and functions of PDZRN3. The PDZRN3 gene was shown to be expressed in various human tissues including the heart, skeletal muscle and liver and its expression in mouse skeletal muscle was developmentally regulated. Both the differentiation of C2C12 mouse skeletal myoblasts into myotubes and injury-induced muscle regeneration in vivo were found to be accompanied by up-regulation of PDZRN3. The differentiation-associated increase in the expression of PDZRN3 in C2C12 cells follows that of myogenin and precedes that of myosin heavy chain. Depletion of PDZRN3 by RNA interference inhibited the formation of myotubes as well as the associated up-regulation of myosin heavy chain in C2C12 cells. Our data suggest that PDZRN3 plays an essential role in the differentiation of myoblasts into myotubes by acting either downstream or independently of myogenin.
VE:
1 * 100 µl
Lieferant:
Merck
Beschreibung:
Tetraethylorthosilikat (TEOS) zur Synthese, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-3751R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3751R-CY5
Lokale Artikelnummer::
BOSSBS-3751R-CY5
Beschreibung:
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3751R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3751R
Lokale Artikelnummer::
BOSSBS-3751R
Beschreibung:
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3751R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3751R-CY7
Lokale Artikelnummer::
BOSSBS-3751R-CY7
Beschreibung:
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
VE:
1 * 100 µl
Artikel-Nr:
(1A00200.)
Lieferant:
USP
Hersteller-Artikelnummer::
1A00200
Lokale Artikelnummer::
USPH1A00200
Beschreibung:
Pharmaceutical Analytical Impurities are released through a USP quality process designed to ensure identity and quality appropriate for analytical applications. These impurities are supported with a product information sheet for each batch.
VE:
1 * 25 mg
Lieferant:
Thermo Scientific
Beschreibung:
Ethanol-[D6], wasserfrei (99% D) für die Kernresonanzspektroskopie
Artikel-Nr:
(BLDPBD00745321-50M)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD00745321-50M
Lokale Artikelnummer::
BLDPBD00745321-50M
Beschreibung:
1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one 95%
VE:
1 * 50 mg
Lieferant:
Alfa Aesar
Beschreibung:
Bortrifluorid-Diethylether-Komplex (≥46,5% BF₃)
Lieferant:
Thermo Scientific
Beschreibung:
4-Ethylpyridin 98%
Lieferant:
Sigma-Aldrich
Beschreibung:
Kaliumformiat, Sigma-Aldrich®
Artikel-Nr:
(APOSBISN0012-50MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
BISN0012-50MG
Lokale Artikelnummer::
APOSBISN0012-50MG
Beschreibung:
AZD1480 is a selective ATP-competitive JAK1/2 inhibitor with IC50 value of 1.3 and <0.4 nM, respectively, as well as shows inhibitory effect on JAK3 and Tyk2.
VE:
1 * 50 mg
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-[2-(Diethylamino)ethoxy]ethanol 98%
Artikel-Nr:
(PRSI25-220)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-220
Lokale Artikelnummer::
PRSI25-220
Beschreibung:
AMOT belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.
VE:
1 * 50 µG
Lieferant:
Alfa Aesar
Beschreibung:
4-Ethylpyridin ≥98%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-Brom-1-ethylpyridiniumtetrafluoroborat 98%
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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