2,3-Naphthalenedialdehyde+(NDA)
Artikel-Nr:
(HONE30104.9010)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
30104.9010
Lokale Artikelnummer::
HONE30104.9010
Beschreibung:
Kaliumfluorid
VE:
1 * 10 kg
Artikel-Nr:
(PRSI91-349)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-349
Lokale Artikelnummer::
PRSI91-349
Beschreibung:
The human Polymeric Immunoglobulin Receptor (pIgR) is a 100 kDa type I transmembrane glycoprotein. Its precursor is 764 amino acids. It contains an 18 amino acid signal sequence, a 620 amino acid extracellular region, a 23 amino acid transmembrane fragment, and a 103 amino acid cytoplasmic domain. pIgR is synthesized by secretory epithelial cells with five Ig-like domains in extracellular region, and transfer to the basolateral plasma membrane. For IgA and IgM polymers, in addition to alpha-heavy chains and light Ig chains, a short polypeptide named joining chain (J chain) is also contained and required. pIgR can bind larger polymers of IgA (pIgA) and pentameric IgM as a carrier that transports IgA and IgM across epithelium. The receptor-ligand complexes are endocytosed and transcytosed to the apical surface, then proteolytic cleavage of the sixth extracellular domain of pIgR and generate secretory IgA (SIgA), the pIgR fragment is referred to as secretory component (SC). SIgA is a important component of the mucosal immune system. SC is anti-microbial properties and protects SIgA from proteolytic degradation
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5215)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5215
Lokale Artikelnummer::
PRSI5215
Beschreibung:
SHOC2 Antibody: SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI33-678)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-678
Lokale Artikelnummer::
PRSI33-678
Beschreibung:
Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI91-096)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-096
Lokale Artikelnummer::
PRSI91-096
Beschreibung:
Chemokine Ligand 26 protein (CCL26) is a novel small cytokine belonging to the CC chemokine family which is involved in immunoregulatory and inflammatory processes. CCL26 is constitutively expressed in thymus, but only transiently expressed in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. CCL26, along with Eotaxin-1 and Eotaxin-2, selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for CCL26 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant CCL26 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines, CCL26 maps to human chromosome 7q11.2, within 40 kilobases of the Eotaxin-2 loci. CCL26 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.
VE:
1 * 50 µG
Artikel-Nr:
(461-0664)
Lieferant:
GRANT INSTRUMENTS
Hersteller-Artikelnummer::
TXF200
Lokale Artikelnummer::
GRANTXF200
Beschreibung:
The Optima™ range of advanced thermostats can be combined with plastic baths, premium stainless steel baths or refrigeration units. The TX150 and TXF200 thermostats feature a full colour QVGA TFT screen displaying actual and set temperature and clear status icons. The QVGA TFT screen, in combination with the easy to use dial and function keys, allows rapid navigation through the intuitive menu system. Both units have RS232 and USB interfaces and can be programmed via remote PC or laptop using Grant’s versatile Labwise™ software (optional). Additional features include countdown timer, adjustable over-temperature cut-out, visual, audible and programmable high and low temperature alarms. The TX150 has the capacity to store one program with 30 segments. The TXF200 can also be programmed via the user interface and can store up to 10 programs containing 100 segments. The programming interface includes set target temperature with a choice of time to target temperature or temperature ramp speed and an additional programmable relay for on/off control of ancillary equipment or refrigeration units.
VE:
1 * 1 ST
Artikel-Nr:
(ABCRAB114501.0025)
Lieferant:
ABCR
Hersteller-Artikelnummer::
AB114501.0025
Lokale Artikelnummer::
ABCRAB114501.0025
Beschreibung:
Wolframatophosphorsäure Hydrat ≥99%
VE:
1 * 25 g
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Artikel-Nr:
(BEPHB160375)
Lieferant:
BEPHARM
Hersteller-Artikelnummer::
B160375
Lokale Artikelnummer::
BEPHB160375
Beschreibung:
2-(Aminomethyl)-5-brompyridin
VE:
1 * 1 g
Artikel-Nr:
(HONE01132.9020)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
01132.9020
Lokale Artikelnummer::
HONE01132.9020
Beschreibung:
Kaliumfluorid ≥99%, gereinigt
VE:
1 * 20 kg
Artikel-Nr:
(PRSI90-528)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-528
Lokale Artikelnummer::
PRSI90-528
Beschreibung:
Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naie CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development). Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-042)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-042
Lokale Artikelnummer::
PRSI91-042
Beschreibung:
Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM R beta ). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFN gamma on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-530)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-530
Lokale Artikelnummer::
PRSI90-530
Beschreibung:
Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naie CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development). Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction.
VE:
1 * 50 µG
Artikel-Nr:
(KWIN125038540D92)
Lieferant:
FRISTADS KANSAS
Hersteller-Artikelnummer::
125038540D92
Lokale Artikelnummer::
KWIN125038540D92
Beschreibung:
Schmutz-, öl- und wasserabweisende Hose mit inhärentem Flammschutz, für ATEX-Umgebungen geeignet, ohne Metallteile. Gefertigt aus 45% Modacryl, 35% Baumwolle, 18% Polyamid und 2% Karbon. Geeignet für Industriewäsche.
VE:
1 * 1 ST
Artikel-Nr:
(PRSI90-529)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-529
Lokale Artikelnummer::
PRSI90-529
Beschreibung:
Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naie CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development). Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction.
VE:
1 * 50 µG
Artikel-Nr:
(HONE01133.9020)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
01133.9020
Lokale Artikelnummer::
HONE01133.9020
Beschreibung:
Kaliumfluorid ≥99%, puriss., reinst
VE:
1 * 20 kg
Artikel-Nr:
(HONE14603.9100)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
14603.9100
Lokale Artikelnummer::
HONE14603.9100
Beschreibung:
Zirkonium(IV)oxid
VE:
1 * 100 kg
Preis auf Anfrage
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