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BIOSS INC
Artikel-Nr:
(BOSSBS-12192R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12192R-A680
Lokale Artikelnummer::
BOSSBS-12192R-A680
Beschreibung:
DPPA5 is a 116 amino acid protein that localizes to the cytoplasm and contains one KH domain. Expressed in embryonic germ (EG), primordial germ (PG) and embryonic stem (ES) cells, DPPA5 plays an important role in the maintenance of ES cell pluripotency and may be necessary for proper embryogenesis. The gene encoding DPPA5 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6872R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6872R-A488
Lokale Artikelnummer::
BOSSBS-6872R-A488
Beschreibung:
Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3311R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3311R-CY5.5
Lokale Artikelnummer::
BOSSBS-3311R-CY5.5
Beschreibung:
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11953R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11953R-CY5
Lokale Artikelnummer::
BOSSBS-11953R-CY5
Beschreibung:
Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1728R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1728R-FITC
Lokale Artikelnummer::
BOSSBS-1728R-FITC
Beschreibung:
Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10367R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10367R-FITC
Lokale Artikelnummer::
BOSSBS-10367R-FITC
Beschreibung:
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11769R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11769R-CY7
Lokale Artikelnummer::
BOSSBS-11769R-CY7
Beschreibung:
The majority of mitochondrial-directed proteins are encoded by the nuclear genome and are transported to the mitochondria via regulated processes involving the mitochondrial Tom and Tim proteins (1). The mitochondrial Tim protein family is comprised of a large group of evolutionarily conserved proteins that are found in most eukaryotes (1,2). Import of nuclear-encoded precursor proteins into and across the mitochondrial inner membrane is mediated by two distinct complexes, the Tim23 complex and the Tim22 complex, which differ in their substrate specificity (1). Defects in Tim proteins are implicated in several neuro-degenerative diseases, suggesting important roles for Tim proteins in development and health (3,4). Tim8A and Tim8B, which map to human chromosomes Xq22.1 and 11q23.1-q23.2, respectively, are conserved proteins of the mitochondrial intermembrane space, which are organized in hetero-oligomeric complex with Tim13 (5,6,7). Tim8A is highly expressed in fetal and adult brain (5). Tim8A is mutated in deafness dystonia syndrome, a novel type of disease that causes severe neurological defects, thought to be caused by a defective mitochondrial protein transport system (5,8).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2600R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2600R-A488
Lokale Artikelnummer::
BOSSBS-2600R-A488
Beschreibung:
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1746R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1746R-FITC
Lokale Artikelnummer::
BOSSBS-1746R-FITC
Beschreibung:
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.DRD4 expression has been reported in various regions of the brain as well as in adrenal gland, artery, eye, heart, kidney, placenta, spinal cord, testis, and vas deferens.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4901R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4901R-A555
Lokale Artikelnummer::
BOSSBS-4901R-A555
Beschreibung:
The Annexins are a family of structurally similar proteins. Annexins bind to phospholipids and may be involved in regulation of membrane transport, membrane channel activity, and interaction of the cell membrane with the extracellular matrix. Annexin A7 is a member of the annexin family of calcium dependent phospholipid binding proteins. The Annexin A7 gene contains 14 exons and spans approximately 34 kb of DNA. Structural analysis of the protein suggests that Annexin A7 is a membrane binding protein with diverse properties including voltage sensitive calcium channel activity, ion selectivity and membrane fusion.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2604R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2604R-CY7
Lokale Artikelnummer::
BOSSBS-2604R-CY7
Beschreibung:
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2321R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2321R-CY5.5
Lokale Artikelnummer::
BOSSBS-2321R-CY5.5
Beschreibung:
Spindly/CCDC99
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6560R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6560R-A680
Lokale Artikelnummer::
BOSSBS-6560R-A680
Beschreibung:
The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localises to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15429R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15429R-A488
Lokale Artikelnummer::
BOSSBS-15429R-A488
Beschreibung:
HCP5 is a region present on chromosome 6p21.3 that is characterised by multiple duplicated gene families. HCP5 (HLA class I histocompatibility antigen protein P5), also known as P5-1, is a 132 amino acid protein that is encoded by a gene mapping to human chromosome 6p21.33. Localising within the MHC class I region, HCP5 is not structurally related to other MHC class I genes, but does have high sequence similarity with HERV-L and HERV-16. HCP5 also has high sequence homology to retroviral Pol genes, making it a possible candidate for interaction with HIV-1 through an antisense mechanism that prevents retrovirus transcription. Single-nucleotide polymorphisms (SNPs) to the region of the HCP5 gene that corresponds with HLA-B has been linked to a lower HIV-1 viral set point. HCP5 is highly expressed in lymphoid tissues, spleen and activated lymphocytes, as well as B-cell and natural killer (NK) cell lines.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12144R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12144R-FITC
Lokale Artikelnummer::
BOSSBS-12144R-FITC
Beschreibung:
Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events (1). Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain (2,3). Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary (4,5). In vascular endothelial cells, Sck participates in VEGF-induced signal transduction (6). Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation (7,8).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5287R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5287R-A750
Lokale Artikelnummer::
BOSSBS-5287R-A750
Beschreibung:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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