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(1-Ethyl-1H-imidazol-5-yl)methanol
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(1-Ethyl-1H-imidazol-5-yl)methanol
Artikel-Nr:
(BOSSBS-12495R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12495R-A750
Lokale Artikelnummer::
BOSSBS-12495R-A750
Beschreibung:
APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12495R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12495R-A680
Lokale Artikelnummer::
BOSSBS-12495R-A680
Beschreibung:
APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.
VE:
1 * 100 µl
Lieferant:
HAMILTON BONADUZ
Beschreibung:
NR = Rheodyne needle
RNR = Replacement Rheodyne needle
Lieferant:
HARVARD APPARATUS
Beschreibung:
The PHD 22/2000 syringe pump series gives you the lowest flow rates, the highest accuracy, the smoothest flow, advanced programmability from the keypad. Ideal for applications in drug/nutritional delivery, electrospinning, microfluidics/nanofluidics and mass spec calibration.
Lieferant:
PAN BIOTECH
Beschreibung:
McCoy's 5A medium is a complete medium with all amino acids and vitamins.
Artikel-Nr:
(MOLE44329754-100G)
Lieferant:
Molekula
Hersteller-Artikelnummer::
44329754-100G
Lokale Artikelnummer::
MOLE44329754-100G
Beschreibung:
m-Toluonitril
VE:
1 * 100 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(BOSSBS-15486R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15486R-A350
Lokale Artikelnummer::
BOSSBS-15486R-A350
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of Zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses Zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localised to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
VE:
1 * 100 µl
Lieferant:
COMBI-BLOCKS
Beschreibung:
6-Iodnicotinonitril
Artikel-Nr:
(BOSSBS-12495R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12495R-A555
Lokale Artikelnummer::
BOSSBS-12495R-A555
Beschreibung:
APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13343R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13343R-A488
Lokale Artikelnummer::
BOSSBS-13343R-A488
Beschreibung:
The GGA family of proteins (Golgi-localized, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin (1?). Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) (1,2,4). GGAs have modular structures with an N-terminal VHS (VPS-27, Hrs, and STAM) domain followed by a GAT (GGA and TOM1) domain, a connecting hinge segment, and a C-terminal GAE (?adaptin ear) domain (5). The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences (3). GGA1 and GGA2 do not associate with each other, but they do colocalize on perinuclear membranes (2). The cytosolic domain of memapsin 2, but not that of memapsin 1, binds the VHS domains of GGA1 and GGA2 (6). The human GGA1 gene maps to chromosome 22 and encodes a protein that shares 45% sequence identity with GGA2 and GGA3 (1).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13343R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13343R-A555
Lokale Artikelnummer::
BOSSBS-13343R-A555
Beschreibung:
The GGA family of proteins (Golgi-localized, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin (1?). Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) (1,2,4). GGAs have modular structures with an N-terminal VHS (VPS-27, Hrs, and STAM) domain followed by a GAT (GGA and TOM1) domain, a connecting hinge segment, and a C-terminal GAE (?adaptin ear) domain (5). The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences (3). GGA1 and GGA2 do not associate with each other, but they do colocalize on perinuclear membranes (2). The cytosolic domain of memapsin 2, but not that of memapsin 1, binds the VHS domains of GGA1 and GGA2 (6). The human GGA1 gene maps to chromosome 22 and encodes a protein that shares 45% sequence identity with GGA2 and GGA3 (1).
VE:
1 * 100 µl
Artikel-Nr:
(BIBB296-02)
Lieferant:
SciLabware
Hersteller-Artikelnummer::
296-02
Lokale Artikelnummer::
BIBB296-02
Beschreibung:
Borosilicate glass 3.3.
VE:
1 * 5 ST
Artikel-Nr:
(STRO669039AG41)
Lieferant:
STRIBEL
Hersteller-Artikelnummer::
669039AG41
Lokale Artikelnummer::
STRO669039AG41
Beschreibung:
Diese robusten, kompakten und vielseitig einsetzbaren Trockenmittelbeutel werden mit Silicagel geliefert, das für pharmazeutische Produkte und Reagenzgläser sowie für klinische Diagnosen und elektrische Werkzeuge verwendet wird.
VE:
1 * 600 ST
Artikel-Nr:
(SHAN3050822)
Lieferant:
Epredia
Hersteller-Artikelnummer::
3050822
Lokale Artikelnummer::
SHAN3050822
Beschreibung:
Choose from HP35, MB22, or MX35 microtome blades.
VE:
1 * 50 ST
Lieferant:
Sigma-Aldrich
Beschreibung:
Bis(2-chlorethyl)ether, Sigma-Aldrich®
Artikel-Nr:
(EDQMN1200000)
Lieferant:
EDQM
Hersteller-Artikelnummer::
N1200000
Lokale Artikelnummer::
EDQMN1200000
Beschreibung:
Organic Standard, Norethisterone
VE:
1 * 25 mg
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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