Suche >
Drucken
Artikel-Nr:
(ABCRAB140481.0500)
Lieferant:
ABCR
Hersteller-Artikelnummer::
AB140481.0500
Lokale Artikelnummer::
ABCRAB140481.0500
Beschreibung:
Cycloocten (Gemisch der cis- und trans-Isomeren)
VE:
1 * 500 mL
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(BOSSBS-8687R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8687R-A488
Lokale Artikelnummer::
BOSSBS-8687R-A488
Beschreibung:
p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8687R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8687R-A350
Lokale Artikelnummer::
BOSSBS-8687R-A350
Beschreibung:
p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
VE:
1 * 100 µl
Artikel-Nr:
(J60574.22)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
J60574.22
Lokale Artikelnummer::
ALFAJ60574.22
Beschreibung:
2-Aminoazotoluol
VE:
1 * 100 g
Lieferant:
Sigma-Aldrich
Beschreibung:
Kaliumoleat, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-2802R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2802R-A750
Lokale Artikelnummer::
BOSSBS-2802R-A750
Beschreibung:
Retinoids are metabolites of vitamin A (retinal) and are believed to represent important signaling molecules during vertebrate development and tissue differentiation. Two families of retinoid receptors have been identified. Retinoic acid receptors (RARs) include RAR alpha, RAR beta and RAR gamma, each of which has a high affinity for all trans retinoic acids and belongs to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. The ligand binding domains of the RARs are highly conserved and RAR isoforms are expressed in distinct patterns through out development and in the mature organism. Members of the retinoid X receptor (RXR) family, RXR alpha, RXR beta and RXR gamma, are activated by 9 cis retinoic acid, a stereo and photoisomer of all trans RA that is expressed in vivo in both liver and kidney and may represent a widely used hormone.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2802R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2802R-CY3
Lokale Artikelnummer::
BOSSBS-2802R-CY3
Beschreibung:
Retinoids are metabolites of vitamin A (retinal) and are believed to represent important signaling molecules during vertebrate development and tissue differentiation. Two families of retinoid receptors have been identified. Retinoic acid receptors (RARs) include RAR alpha, RAR beta and RAR gamma, each of which has a high affinity for all trans retinoic acids and belongs to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. The ligand binding domains of the RARs are highly conserved and RAR isoforms are expressed in distinct patterns through out development and in the mature organism. Members of the retinoid X receptor (RXR) family, RXR alpha, RXR beta and RXR gamma, are activated by 9 cis retinoic acid, a stereo and photoisomer of all trans RA that is expressed in vivo in both liver and kidney and may represent a widely used hormone.
VE:
1 * 100 µl
Artikel-Nr:
(SIAL62262-500ML-F)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
62262-500ML-F
Lokale Artikelnummer::
SIAL62262-500ML-F
Beschreibung:
Ethyllinoleat 65% in wässriger Lösung 65% (durch GC), technische Qualität, Sigma-Aldrich®
VE:
1 * 500 mL
Artikel-Nr:
(BOSSBS-13492R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13492R-HRP
Lokale Artikelnummer::
BOSSBS-13492R-HRP
Beschreibung:
The Golgi apparatus is a highly complex organelle comprised of a stack of cisternal membranes on the secretory pathway from the ER to the cell surface. The structure is maintained by an exoskeleton or Golgi matrix constructed from a family of coiled-coil protein, the golgins and other peripheral membrane components such as GRASP55 and GRASP65 (1). GRASP55 (Golgi reassembly stacking protien or p59) is a component of the Golgi stacking machinery. GRASP55 is highly homologous to GRASP65 and contains two PDZ domains. GRASP55 is myristoylated and palmitoylated. Unlike GRASP65, GRASP55 does not have detectable binding with the vesicle docking protein GM130 and is located on the medial-Golgi rather than cis-Golgi. Both GRASP55 and GRASP65 function in the stacking of Golgi Cisternae (2,3). The novel coiled-coil protein golgin 45 interacts with GRASP55 and the GTP form of Rab 2, suggesting that GRASP55 and golgin 45 form a Rab 2 effector complex on medial-Golgi essential for normal protein transport and Golgi structure (4). ERK2 directly phosphorylates GRASP55, which is phosphorylated in mitotic cells, suggesting that mitogen-activated protein kinase kinase (MKK)/ERK pathway phosphorylates the Golgi during mitosis (5).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0251R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0251R-A488
Lokale Artikelnummer::
BOSSBS-0251R-A488
Beschreibung:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0251R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0251R-A555
Lokale Artikelnummer::
BOSSBS-0251R-A555
Beschreibung:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
VE:
1 * 100 µl
Lieferant:
Sigma-Aldrich
Beschreibung:
Ethyl-3-methyl-3-phenylglycidat (Gemisch der cis- und trans-Isomeren), Sigma-Aldrich®
Artikel-Nr:
(SERA16180.02)
Lieferant:
Serva
Hersteller-Artikelnummer::
16180.02
Lokale Artikelnummer::
SERA16180.02
Beschreibung:
Carmin (Calcium-Aluminium-Verlackung von Carminsäure)
VE:
1 * 25 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(NUCKGLC-411.0001)
Lieferant:
NU-CHEK-PREP
Hersteller-Artikelnummer::
GLC-411.0001
Lokale Artikelnummer::
NUCKGLC-411.0001
Beschreibung:
γ-Linolensäuremethylester
VE:
1 * 1 ST
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(EHERC10202000)
Lieferant:
EHRENSTORFER
Hersteller-Artikelnummer::
C10202000
Lokale Artikelnummer::
EHERC10202000
Beschreibung:
2-Aminoazotoluol
VE:
1 * 0,25 g
Artikel-Nr:
(EHERXA11201000CY)
Lieferant:
EHRENSTORFER
Hersteller-Artikelnummer::
XA11201000CY
Lokale Artikelnummer::
EHERXA11201000CY
Beschreibung:
Organic Standard, cis-Chlordan 100 µg/ml in Cyclohexan, Packung: Glasflasche
VE:
1 * 1 mL
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
Dieses Produkt ist nicht mehr verfügbar. Bitte kontaktieren Sie den VWR Kundenservice.
|
|||||||||
Listenansicht
