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Methyl-4\'-brombiphenyl-4-carboxylat
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Methyl-4\'-brombiphenyl-4-carboxylat
Artikel-Nr:
(BOSSBS-7053R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7053R-FITC
Lokale Artikelnummer::
BOSSBS-7053R-FITC
Beschreibung:
Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13162R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13162R-A350
Lokale Artikelnummer::
BOSSBS-13162R-A350
Beschreibung:
Ficolin B is the designation in mouse and rat of a protein also known as L-ficolin, ficolin-2, collagen/fibrinogen domain-containing protein 2, serum lectin p35, EBP-37 or hucolin. Ficolin B is a 313 amino acid member of the ficolin lectin family. It is a secreted innate immunity pattern recognition molecule expressed in liver and plasma that forms a disulfide-linked homopolymer. This extensive N-terminal disulfide bridge formation can lead to a functional dodecamer polypeptide. Ficolin B binds to DNA ligands expressed by late apoptotic and necrotic cells to increase attachment and engulfment. Variation in ficolin B concentrations amongst individuals is associated with polymorphisms in the promoter and structural portion of the FCN2 gene. In patients with Behé´t's disease (BD), there exists a significant difference in allele frequency for FCN2 gene single nucleotide polymorphisms (SNPs) within the -557 and -64 promoter sites within HLA-B51 positive and HLA-B51 negative subgroups.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13182R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13182R-CY3
Lokale Artikelnummer::
BOSSBS-13182R-CY3
Beschreibung:
Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12922R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12922R-HRP
Lokale Artikelnummer::
BOSSBS-12922R-HRP
Beschreibung:
The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf’s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11562R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11562R-A647
Lokale Artikelnummer::
BOSSBS-11562R-A647
Beschreibung:
Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord. SMA is caused by deletion or loss-of-function mutations in the SMN (survival of motor neuron) gene. Gemin2 (formerly known as SIP1 for SMN interacting protein) associates directly with SMN and is a part of the SMN complex containing Gemin3 (a DEAD-box RNA helicase), Gemin4, Gemin5 and Gemin6, as well as several spliceosomal snRNP proteins. The SMN complex plays an essential role in splicesomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus. It is found in both the cytoplasm and the nucleus. The nuclear form is concentrated in subnuclear bodies called gems (Gemini of the coiled bodies). The SMN-Gemin2 complex is associated with spliceosomal snRNAs U1 and U5. Gemin2 is expressed in spinal cord. It can be induced by TGF∫ treatment and expression is high in several E-cadherin negative human carcinoma cell lines. SMN is expressed in a wide variety of tissues including brain, kidney, liver and spinal cord, and moderately in skeletal and cardiac muscle. The gene encoding Gemin2 maps to human chromosome 14q13.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4814R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4814R
Lokale Artikelnummer::
BOSSBS-4814R
Beschreibung:
Anti-Newcastle disease virus Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3776R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3776R-HRP
Lokale Artikelnummer::
BOSSBS-3776R-HRP
Beschreibung:
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5067R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5067R-A555
Lokale Artikelnummer::
BOSSBS-5067R-A555
Beschreibung:
Hydroxymethylglutaryl-CoA lyase (HMGCL) is found in fibroblasts, liver and lymphoblasts. It has a role in ketogenesis and leucine catabolism. Defects in HMGCL are the cause of 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (hydroxymethylglutaricaciduria), an autosomal recessive disease which can lead to hypoglycemia and coma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15170R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15170R-A680
Lokale Artikelnummer::
BOSSBS-15170R-A680
Beschreibung:
Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. The C3orf25 gene product has been provisionally designated C3orf25 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5563R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5563R-A680
Lokale Artikelnummer::
BOSSBS-5563R-A680
Beschreibung:
Members of the protein kinase C (PKC) family function in many extracellular receptor-mediated signal transduction pathways. See PRKCA (MIM 176960) for further background information. The PRKCM gene encodes a cytosolic serine-threonine kinase that binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface.[supplied by OMIM].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9733R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9733R-A555
Lokale Artikelnummer::
BOSSBS-9733R-A555
Beschreibung:
UFD1L is a member of the UFD1 family of proteins and is a component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. This complex, also containing UFD1L, VCP and NPLOC4, binds ubiquitinated proteins and is required for the export of misfolded proteins from the ER to the cytoplasm for disposal. The NPLOC4-UFD1L-VCP complex also regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. UFD1L gene hemizygosity is the cause of some developmental defects including DiGeorge syndrome (DGS), velo-cardio-facial syndrome (VCFS) and Opitz G/BBB syndrome. UFD1L has 2 named isoforms produced by alternative splicing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10207R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10207R-CY7
Lokale Artikelnummer::
BOSSBS-10207R-CY7
Beschreibung:
Respiratory syncytial virus (RSV) is a major cause of respiratory illness in young children. RSV infection produces a variety of signs and symptoms involving different areas of the respiratory tract, from the nose to the lungs. RSV is a negative sense, enveloped RNA virus. The virion is variable in shape and size with average diameter of between 120 and 300 nm.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9535R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9535R-A750
Lokale Artikelnummer::
BOSSBS-9535R-A750
Beschreibung:
Making up nearly 6% of the human genome, chromosome 6 contains around 1200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatibility complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf134 gene product has been provisionally designated C6orf134 pending further characterisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7528R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7528R-FITC
Lokale Artikelnummer::
BOSSBS-7528R-FITC
Beschreibung:
CTRP1 enhances the production of aldosterone. CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13334R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13334R-HRP
Lokale Artikelnummer::
BOSSBS-13334R-HRP
Beschreibung:
Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4256R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4256R-A680
Lokale Artikelnummer::
BOSSBS-4256R-A680
Beschreibung:
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centres can be oxidised to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidised Trx is catalysed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1. Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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