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BIOSS INC
Artikel-Nr:
(BOSSBS-6634R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6634R-CY7
Lokale Artikelnummer::
BOSSBS-6634R-CY7
Beschreibung:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2469R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2469R-FITC
Lokale Artikelnummer::
BOSSBS-2469R-FITC
Beschreibung:
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1768R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1768R
Lokale Artikelnummer::
BOSSBS-1768R
Beschreibung:
Anti-FGFBP1 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11514R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11514R-A647
Lokale Artikelnummer::
BOSSBS-11514R-A647
Beschreibung:
The cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5220R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5220R-CY3
Lokale Artikelnummer::
BOSSBS-5220R-CY3
Beschreibung:
BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants (alpha and beta) produced by alternate splicing, differ in their C-terminal ends. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability. It appears to function in a feedback loop system with caspases. BCL2 inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF1). It can form homodimers, and heterodimers with BAX, BAD, BAK and BclX(L). Heterodimerization with BAX requires intact BH1 and BH2 domains, and is necessary for anti-apoptotic activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5883R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5883R-A647
Lokale Artikelnummer::
BOSSBS-5883R-A647
Beschreibung:
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11663R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11663R-A647
Lokale Artikelnummer::
BOSSBS-11663R-A647
Beschreibung:
Phosphatidylethanolamine (PtdEtn) is a major membrane phospholipid which serves to play a primary role in cell membrane structure and is also involved in cell division, cell signaling, activation, phagocytosis and autophagy. PCYT2 (Phosphorylethanolamine transferase), also known as Ethanolamine-phosphate cytidylyltransferase, is a 389 amino acid protein that catalyzes the formation of CDP-ethanolamine from ethanolamine. This product combined with diacylglycerol form phosphatidylethanolamine via the de novo Kennedy pathway. PCYT2 is expressed at highest levels in heart, liver and skeletal muscle. Elevated levels of MyoD, reduced content of Sp1 and a changed ratio of Sp1 to Sp3 all together stimulate upregulation of PCTY2 transcription during C2C12 muscle cell differentiation. Disruption of the PCYT2 gene in mice leads to death after embryo implantation, establishing the necessity of PCYT2 for murine development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9541R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9541R-CY3
Lokale Artikelnummer::
BOSSBS-9541R-CY3
Beschreibung:
Orai2 is a 254 amino acid multi-pass membrane protein that belongs to the orai family of proteins. Localizing to the plasma membrane, Orai2 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. CRAC channels are responsible for medi-ating calcium influx in T-cells and play an important role in the immune response. Orai2 specifically increases the Ca2+-selective current through coaction with the Ca2+ sensor Stim1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0912R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0912R-A647
Lokale Artikelnummer::
BOSSBS-0912R-A647
Beschreibung:
No data available.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4791R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4791R-HRP
Lokale Artikelnummer::
BOSSBS-4791R-HRP
Beschreibung:
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4008R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4008R-A647
Lokale Artikelnummer::
BOSSBS-4008R-A647
Beschreibung:
Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3429R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3429R-A488
Lokale Artikelnummer::
BOSSBS-3429R-A488
Beschreibung:
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11129R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11129R-A647
Lokale Artikelnummer::
BOSSBS-11129R-A647
Beschreibung:
May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9100R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9100R-A350
Lokale Artikelnummer::
BOSSBS-9100R-A350
Beschreibung:
Arylsulfatase F, also known as ARSF, is a 590 amino acid secretory protein that belongs to the sulfatase family of bone and cartilage matrix proteins. Arylsulfatase F uses calcium as a cofactor to catalyze reactions that are important in maintaining correct bone composition. The activity of Arylsulfatase F, unlike that of other family members, such as Arylsulfatase E, is not inhibited by warfarin. The gene encoding Arylsulfatase F maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes. In conjunction with chromosome Y, chromosome X is responsible for sex determination. There are a number of conditions related to an abnormal number and combination of sex chromosomes, some of which include Turner's syndrome, color blindness, hemophilia and Duchenne muscular dystrophy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0582R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0582R-A680
Lokale Artikelnummer::
BOSSBS-0582R-A680
Beschreibung:
This is one of two genes encoding similar enzymes that catalyse the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8641R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8641R-CY7
Lokale Artikelnummer::
BOSSBS-8641R-CY7
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC1 (zinc finger, DHHC-type containing 1), also known as ZNF377 (zinc finger protein 377) or C16orf1, is a 485 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger. Expressed in fetal heart, lung and kidney and also present in adult lung and pancreas, ZDHHC1 functions as a palmitoyltransferase that catalyzes the conversion of palmitoyl-CoA and protein-cysteine to S-palmitoyl protein and CoA. Like ZDHHC1, ZDHHC5, ZDHHC6, ZDHHC7 and ZDHHC18 each contain one DHHC-type zinc finger through which they convey palmitoyltransferase activity against a broad range of substrates, including H-Ras, SNAP 25 and GABAA R proteins.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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