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3-Chlor-5-propoxyphenylborons\\u00E4urepinakolester
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3-Chlor-5-propoxyphenylborons\\u00E4urepinakolester
Artikel-Nr:
(BOSSBS-1373R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1373R-A680
Lokale Artikelnummer::
BOSSBS-1373R-A680
Beschreibung:
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1373R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1373R-A350
Lokale Artikelnummer::
BOSSBS-1373R-A350
Beschreibung:
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5379R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5379R-HRP
Lokale Artikelnummer::
BOSSBS-5379R-HRP
Beschreibung:
Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6760R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6760R-A488
Lokale Artikelnummer::
BOSSBS-6760R-A488
Beschreibung:
Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
VE:
1 * 100 µl
Lieferant:
VWR Collection
Beschreibung:
Nahezu alle Septen sind einseitig mit PTFE laminiert (hohe chemische Beständigkeit) und bilden eine inerte Barriere zwischen Trägermaterial und Probe.
Lieferant:
VWR Collection
Beschreibung:
Nahezu alle Septen sind einseitig mit PTFE laminiert (hohe chemische Beständigkeit) und bilden eine inerte Barriere zwischen Trägermaterial und Probe.
Artikel-Nr:
(BOSSBS-3665R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3665R-A555
Lokale Artikelnummer::
BOSSBS-3665R-A555
Beschreibung:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. [provided by RefSeq].The antibody should recognize both pro-form and p20 cleaved-form. The antibody does not cross-react with other Caspase family members.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12910R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12910R-A488
Lokale Artikelnummer::
BOSSBS-12910R-A488
Beschreibung:
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11655R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11655R-CY7
Lokale Artikelnummer::
BOSSBS-11655R-CY7
Beschreibung:
The large chondroitin sulfate proteoglycan, aggrecan, is the predominant proteoglycan present in cartilage. Aggrecan is a member of the chondroitin sulphate proteoglycan family, which also includes versican/PG-M, neurocan and brevican. Aggrecan is a complex multidomain macromolecule that undergoes extensive processing and post-translational modification. Aggrecan in cartilage forms aggregates with hyaluronan and link protein, embedded in a collagen network. Aggrecan accounts for the compressive stiffness and resilience of the hyaline cartilage. Many forms of inflammatory arthritis are shown to be accompanied with aggrecan degradation and loss from the cartilage. Brevican is a brain proteoglycan of the aggrecan/versican/neurocan family. In the adult brain, the brevican core protein undergoes proteolytic cleavage and exists as a full-length form a carboxy-terminal fragment and an amino-terminal fragment.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9339R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9339R-CY5.5
Lokale Artikelnummer::
BOSSBS-9339R-CY5.5
Beschreibung:
MARCH5 is a member of the E3 ubiquitin-protein ligase family. This mitochonrial E3 ubiquitin-protein ligase plays an importnat role in controlling the morphology of the mitochondria. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. MARCH5 has been shown to interact with MTFN2 and ubiquitinated forms of DRP1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9339R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9339R-CY5
Lokale Artikelnummer::
BOSSBS-9339R-CY5
Beschreibung:
MARCH5 is a member of the E3 ubiquitin-protein ligase family. This mitochonrial E3 ubiquitin-protein ligase plays an importnat role in controlling the morphology of the mitochondria. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. MARCH5 has been shown to interact with MTFN2 and ubiquitinated forms of DRP1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13187R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13187R-CY5
Lokale Artikelnummer::
BOSSBS-13187R-CY5
Beschreibung:
In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13187R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13187R-CY7
Lokale Artikelnummer::
BOSSBS-13187R-CY7
Beschreibung:
In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.
VE:
1 * 100 µl
Lieferant:
SIGMA ALDRICH MICROSCOPY
Beschreibung:
3,3′-Diaminobenzidine has been used as a chromogen for the visualisation in immunohistochemistry of chondrosarcoma sections, mammary carcinomas and brain tissue sections. Peroxidase substrate; reagent for spectrophotometric determination of selenium. DAB (3,3′-Diaminobenzidine) is utilized in many applications for the visualisation of peroxidase activity. In the peroxidase reaction, DAB serves as a hydrogen donor in the presence of peroxide. The oxidised DAB forms an insoluble brown end-product for use in the immunohistological and immunoblotting staining procedures.
Artikel-Nr:
(BOSSBS-11655R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11655R-A750
Lokale Artikelnummer::
BOSSBS-11655R-A750
Beschreibung:
The large chondroitin sulfate proteoglycan, aggrecan, is the predominant proteoglycan present in cartilage. Aggrecan is a member of the chondroitin sulphate proteoglycan family, which also includes versican/PG-M, neurocan and brevican. Aggrecan is a complex multidomain macromolecule that undergoes extensive processing and post-translational modification. Aggrecan in cartilage forms aggregates with hyaluronan and link protein, embedded in a collagen network. Aggrecan accounts for the compressive stiffness and resilience of the hyaline cartilage. Many forms of inflammatory arthritis are shown to be accompanied with aggrecan degradation and loss from the cartilage. Brevican is a brain proteoglycan of the aggrecan/versican/neurocan family. In the adult brain, the brevican core protein undergoes proteolytic cleavage and exists as a full-length form a carboxy-terminal fragment and an amino-terminal fragment.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11655R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11655R-A680
Lokale Artikelnummer::
BOSSBS-11655R-A680
Beschreibung:
The large chondroitin sulfate proteoglycan, aggrecan, is the predominant proteoglycan present in cartilage. Aggrecan is a member of the chondroitin sulphate proteoglycan family, which also includes versican/PG-M, neurocan and brevican. Aggrecan is a complex multidomain macromolecule that undergoes extensive processing and post-translational modification. Aggrecan in cartilage forms aggregates with hyaluronan and link protein, embedded in a collagen network. Aggrecan accounts for the compressive stiffness and resilience of the hyaline cartilage. Many forms of inflammatory arthritis are shown to be accompanied with aggrecan degradation and loss from the cartilage. Brevican is a brain proteoglycan of the aggrecan/versican/neurocan family. In the adult brain, the brevican core protein undergoes proteolytic cleavage and exists as a full-length form a carboxy-terminal fragment and an amino-terminal fragment.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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