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6-Fluoro-2-methylnicotinic+acid
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6-Fluoro-2-methylnicotinic+acid
Artikel-Nr:
(BOSSBS-1548R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1548R-A555
Lokale Artikelnummer::
BOSSBS-1548R-A555
Beschreibung:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. recognises and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34C expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5965R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5965R-A647
Lokale Artikelnummer::
BOSSBS-5965R-A647
Beschreibung:
The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13246R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13246R-A488
Lokale Artikelnummer::
BOSSBS-13246R-A488
Beschreibung:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10127R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10127R-A350
Lokale Artikelnummer::
BOSSBS-10127R-A350
Beschreibung:
Linker for activation of T cells (LAT) is an integral membrane protein (36 to 38 kD), which plays an important role in linking engagement of the TCR to the biochemical events of T cell activation. LAT antibody stains thymus and peripheral lymphoid tissues such as T cell areas in lymph nodes and spleen. LAT is expressed in T lymphocytes in interstitial spaces, platelets and megakaryocytes. LAT is not expressed in B cells, macrophages, plasma cells, monocytes, epithelial histiocytes and dendritic cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0134R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0134R-A488
Lokale Artikelnummer::
BOSSBS-0134R-A488
Beschreibung:
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11174R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11174R-A555
Lokale Artikelnummer::
BOSSBS-11174R-A555
Beschreibung:
KY peptidase (Kyphoscoliosis peptidase) is a 561 amino acid cytoskeleton protease that interacts with several sarcomeric cytoskeletal proteins, including Filamin 2. KY peptidase probably plays a role in the maturation, function and stabilization of the neuromuscular junction. KY-null mouse mutants exhibit distinct irregular subceullular Filamin 2 localization, suggesting that KY peptidase deficiency may be the cause of several types of limb-girdle muscular dystrophies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-20130R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-20130R-A680
Lokale Artikelnummer::
BOSSBS-20130R-A680
Beschreibung:
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6256R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6256R-A350
Lokale Artikelnummer::
BOSSBS-6256R-A350
Beschreibung:
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5786R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5786R-A750
Lokale Artikelnummer::
BOSSBS-5786R-A750
Beschreibung:
Kallistatin is a serine proteinase inhibitor which binds to tissue kallikrein and inhibits its amidolytic and kininogenase activity. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2883R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2883R-A680
Lokale Artikelnummer::
BOSSBS-2883R-A680
Beschreibung:
This protein belongs to a G protein coupled heptahelical receptor subfamily named Endothelial Cell Differentiation Genes (EDG)that act as receptors for biologically active lysophospholipids. This group consists of two receptor subgroups specific for S1P and LPA respectively. EDG6 is the receptor for lysophospholipid sphingosine 1 phosphate (S1P). S1P elicits diverse physiological effect on most types of cells and tissues. EDG6 may be involved in cell migration processes that are specific for lymphocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12344R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12344R-A680
Lokale Artikelnummer::
BOSSBS-12344R-A680
Beschreibung:
FLVCR is responsible for the exportation of cytoplasmic heme groups. It is believed that it may protect developing erythroid cells from heme toxicity. Expression of FLVCR in cells will cause susceptibility to FeLV-C (Feline leukaemia virus subgroup C) in vitro. FLVCR is found in all hematopoietic tissues, including peripheral blood lymphocytes and fetal liver, and some expression is found in pancreas and kidney. It is down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0134R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0134R-A750
Lokale Artikelnummer::
BOSSBS-0134R-A750
Beschreibung:
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilisation of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6901R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6901R-A350
Lokale Artikelnummer::
BOSSBS-6901R-A350
Beschreibung:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENP-T is one of the basic inner kinetochore proteins with most further proteins binding downstream, suggesting a fundamental role of CENP-T in kinetochore function.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1444R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1444R-A750
Lokale Artikelnummer::
BOSSBS-1444R-A750
Beschreibung:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5121R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5121R-A750
Lokale Artikelnummer::
BOSSBS-5121R-A750
Beschreibung:
This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7608R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7608R-A350
Lokale Artikelnummer::
BOSSBS-7608R-A350
Beschreibung:
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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