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1,1-Diphenylhydrazin+Hydrochlorid
Artikel-Nr:
(BOSSBS-3054R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3054R-A647
Lokale Artikelnummer::
BOSSBS-3054R-A647
Beschreibung:
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3054R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3054R-A680
Lokale Artikelnummer::
BOSSBS-3054R-A680
Beschreibung:
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilisation and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1769R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1769R-A680
Lokale Artikelnummer::
BOSSBS-1769R-A680
Beschreibung:
Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also Hydrolyse P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1124R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1124R-A647
Lokale Artikelnummer::
BOSSBS-1124R-A647
Beschreibung:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10221R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10221R
Lokale Artikelnummer::
BOSSBS-10221R
Beschreibung:
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013].
VE:
1 * 100 µl
Artikel-Nr:
(UVEX9400.517)
Lieferant:
UVEX
Hersteller-Artikelnummer::
9400.517
Lokale Artikelnummer::
UVEX9400.517
Beschreibung:
Ersatzscheibe, CA farblos, beschlagfrei, Farbe (Linse): Klar, Beschlagschutz: +
VE:
1 * 10 ST
Artikel-Nr:
(681507-1)
Lieferant:
Merck Millipore (Oncogene)
Hersteller-Artikelnummer::
681507-1
Lokale Artikelnummer::
ONCO681507-1
Beschreibung:
Anti-Ca V 1.2 (818-835) Rabbit Polyclonal Antibody
VE:
1 * 1 ST
Artikel-Nr:
(QEDB11505)
Lieferant:
QED Bioscience
Hersteller-Artikelnummer::
11505
Lokale Artikelnummer::
QEDB11505
Beschreibung:
Anti-Cav3.2 Ca+2 Channel Mouse Monoclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(QEDB11565)
Lieferant:
QED Bioscience
Hersteller-Artikelnummer::
11565
Lokale Artikelnummer::
QEDB11565
Beschreibung:
Anti-Cav3.1 Ca+2 Channel Mouse Monoclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-10397R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10397R-A647
Lokale Artikelnummer::
BOSSBS-10397R-A647
Beschreibung:
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11359R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11359R-A750
Lokale Artikelnummer::
BOSSBS-11359R-A750
Beschreibung:
Rab 3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca²⁺ regulated exocytosis and functions in an inhibitory capacity, controlling the recruitment and pooling of secretory vesicles at the plasma membrane. The Rim (Rab 3 interacting molecule) family of proteins (Rim1, Rim2, Rim3 and Rim4) are multidomain adaptors that regulate Rab 3 activity and sub-sequent neurotransmitter release. Rim3, also known as RIMS3 (regulating synaptic membrane exocytosis 3) or NIM3, is a 308 amino acid member of the Rim family. localised to the synapse and to cell junctions, Rim3 contains one C2 domain and is thought to play an important role in the regulation of synaptic membrane exocytosis. Rim3, a protein that may be phosphorylated upon DNA damage, is expressed throughout the body with highest levels present in brain tissue.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11066R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11066R-A750
Lokale Artikelnummer::
BOSSBS-11066R-A750
Beschreibung:
The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11066R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11066R-CY5
Lokale Artikelnummer::
BOSSBS-11066R-CY5
Beschreibung:
The downstream of kinase family (Dok-1-7) are members of a class of “docking†proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2748R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2748R-FITC
Lokale Artikelnummer::
BOSSBS-2748R-FITC
Beschreibung:
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2748R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2748R-A647
Lokale Artikelnummer::
BOSSBS-2748R-A647
Beschreibung:
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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