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2-Chlor-6-fluor-3-methoxybenzylamin
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2-Chlor-6-fluor-3-methoxybenzylamin
Artikel-Nr:
(BOSSBS-2923R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2923R-A647
Lokale Artikelnummer::
BOSSBS-2923R-A647
Beschreibung:
Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1, SFRS2 and ZRSR2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7523R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7523R-A350
Lokale Artikelnummer::
BOSSBS-7523R-A350
Beschreibung:
Cellular localization: Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane. Membrane >caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4138R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4138R-A488
Lokale Artikelnummer::
BOSSBS-4138R-A488
Beschreibung:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK11 is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5974R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5974R-A647
Lokale Artikelnummer::
BOSSBS-5974R-A647
Beschreibung:
SMYD3 is a gene that is over-expressed in the majority of colorectal carcinomas and hepatocellular carcinomas. SMYD3 forms a complex with RNA polymerase II through an interaction with the RNA helicase HELZ and transactivates a set of genes that included oncogenes, homeobox genes and genes associated with cell-cycle regulation. SMYD3 binds to a motif, 5'-CCCTCC-3', present in the promoter region of downstream genes such as Nkx2.8. The SET domain of SMYD3 shows histone H3-lysine 4 (H3-K4)-specific methyltransferase activity, which is enhanced in the presence of the heat-shock protein HSP90A.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5669R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5669R-A647
Lokale Artikelnummer::
BOSSBS-5669R-A647
Beschreibung:
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12036R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12036R-A350
Lokale Artikelnummer::
BOSSBS-12036R-A350
Beschreibung:
With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6947R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6947R-A555
Lokale Artikelnummer::
BOSSBS-6947R-A555
Beschreibung:
KRT82 is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0224R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0224R-A350
Lokale Artikelnummer::
BOSSBS-0224R-A350
Beschreibung:
Nuclear co-repressor 2 (N-CoR2) gene (NCOR2, previously called silencing mediator for retinoid and thyroid hormone receptor SMRT) is recruited to nuclear and non-nuclear receptors in a large repressing complex containing also N-CoR1, mSin3 and HDACs. This large complex represses transcription in absence of ligand. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Tissue specificity: Ubiquitous. It is belongs to the N-CoR nuclear receptor corepressors family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1280R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1280R-A555
Lokale Artikelnummer::
BOSSBS-1280R-A555
Beschreibung:
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6383R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6383R-A555
Lokale Artikelnummer::
BOSSBS-6383R-A555
Beschreibung:
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12881R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12881R-A488
Lokale Artikelnummer::
BOSSBS-12881R-A488
Beschreibung:
ABTB1 is a 478 amino acid protein localized to the cytoplasm. ABTB1 contains two ANK repeats and two BTB (POZ) domains. The BTB (POZ) domain is thought to be involved in protein-protein interactions, and may indicate a role of ABTB1 in developmental processes. It has also been suggested that ABTB1 may be a mediator of the PTEN growth-suppressive signaling pathway. ABTB1 is ubiquitously expressed in all fetal tissues, with lower levels of expression found in adult heart. ABTB1 exists as four isoforms produced by alternative splicing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3354R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3354R-A350
Lokale Artikelnummer::
BOSSBS-3354R-A350
Beschreibung:
Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3311R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3311R-A555
Lokale Artikelnummer::
BOSSBS-3311R-A555
Beschreibung:
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3973R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3973R-A680
Lokale Artikelnummer::
BOSSBS-3973R-A680
Beschreibung:
UQCRC2 is a component of the ubiquinol cytochrome c reductase complex (complex III), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8272R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8272R-A555
Lokale Artikelnummer::
BOSSBS-8272R-A555
Beschreibung:
Highly expressed in spleen, lymph nodes, lung and placenta. Expressed at moderate level in thymus, kidney, heart and digestive tract. Weakly expressed in other lymphoid tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5968R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5968R-A680
Lokale Artikelnummer::
BOSSBS-5968R-A680
Beschreibung:
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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