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2-Fluor-4-methylphenylborons\u00E4ure
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2-Fluor-4-methylphenylborons\u00E4ure
Artikel-Nr:
(BOSSBS-7536R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7536R-A750
Lokale Artikelnummer::
BOSSBS-7536R-A750
Beschreibung:
Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7694R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7694R-A680
Lokale Artikelnummer::
BOSSBS-7694R-A680
Beschreibung:
Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6431R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6431R-A680
Lokale Artikelnummer::
BOSSBS-6431R-A680
Beschreibung:
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8198R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8198R-A680
Lokale Artikelnummer::
BOSSBS-8198R-A680
Beschreibung:
Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8306R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8306R-A488
Lokale Artikelnummer::
BOSSBS-8306R-A488
Beschreibung:
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6397R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6397R-A680
Lokale Artikelnummer::
BOSSBS-6397R-A680
Beschreibung:
SCGB3A1 is a secreted cytokine-like protein, which has been shown to inhibit cell growth <i>in vitro</i>.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6431R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6431R-A750
Lokale Artikelnummer::
BOSSBS-6431R-A750
Beschreibung:
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15513R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15513R-A350
Lokale Artikelnummer::
BOSSBS-15513R-A350
Beschreibung:
Eotaxin 3 is a recently discovered CC chemokine. It binds to the CCR3 receptor and is highly chemotactic for eosinophils and basophils.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2676R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2676R-A555
Lokale Artikelnummer::
BOSSBS-2676R-A555
Beschreibung:
Thyroid stimulating hormone, also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9489R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9489R-A680
Lokale Artikelnummer::
BOSSBS-9489R-A680
Beschreibung:
C9orf46 is a 147 amino acid transmembrane protein. The gene encoding C9orf46 maps to human chromosome 9, which consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterised by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukaemias.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11318R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11318R-A647
Lokale Artikelnummer::
BOSSBS-11318R-A647
Beschreibung:
The human ataxin-7 gene, also known as spinocerebellar ataxia 7 or SCA7, maps to chromosome 3p13-p12, has a 2,727-bp open reading frame, and encodes a 892 amino acid protein containing a nuclear localization signal and a polyglutamine tract (1,2). SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product (3,4). Ataxin-7 is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype (5). Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function (6).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13116R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13116R-A647
Lokale Artikelnummer::
BOSSBS-13116R-A647
Beschreibung:
Transmembrane channel-like protein 8 (TMC8), also known as Epidermodysplasia verruciformis protein 2 (EVER2), is a 726 amino acid member of the TMC family of proteins. Localized to the endoplasmic reticulum membrane, TMC8 is thought to form a transmembrane channel-like protein with eight predicted transmembrane domains and three leucine zipper motifs. Mutations in the genes encoding TMC8 and TMC6, another member of the TMC family, have been shown to cause epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. Infection by HPVs lead to persistent wart-like or macular lesions. TMC8 is expressed in placenta, prostate and testis, and three named isoforms exist as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3541R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3541R-A350
Lokale Artikelnummer::
BOSSBS-3541R-A350
Beschreibung:
Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2158R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2158R-A647
Lokale Artikelnummer::
BOSSBS-2158R-A647
Beschreibung:
Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13286R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13286R-A555
Lokale Artikelnummer::
BOSSBS-13286R-A555
Beschreibung:
GARNL1 is expressed during embryogenesis with E12. During development, GARNL1 expression decreases, persisting at high levels only in neurons of the adult brain. GARNL1 localizes to the cytoplasm where it may play a role regulating GTP hydrolysis of proteins such as Ran and Rap. GARNL1 is imported to the nucleus via dimerization with E12. GARNL1 interacts with the HLH region of E12 and may function to negatively regulate the transcription of E12-dependent downstream target genes. This suggests that at least a portion of the function of GARNL1 is dependent upon its association with E12. GARNL1 may also associate with other HLH proteins and influence a variety of HLH signaling cascades. In adult brain, GARNL1 activity does not involve E12 and therefore it may serve a different function in developed neural tissue.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13270R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13270R-A555
Lokale Artikelnummer::
BOSSBS-13270R-A555
Beschreibung:
The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosaminyl) to serine and threonine residues of various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T10 (Polypeptide N-acetylgalactosaminyltransferase 10), also known as UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10, is a 603 amino acid single-pass type II membrane protein that prefers Muc5Ac and EA2 peptide substrates. The N-terminal domain is involved in substrate binding and manganese coordination, while the C-terminal domain is involved in UDP-Gal binding and catalytic reaction. GalNAc-T10 is widely expressed, with highest levels found in small intestine. There are four isoforms of GalNAc-T10 that are produced as a result of alternative splicing events.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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