2-Fluor-5-nitro-6-picolin
Artikel-Nr:
(BOSSBS-9411R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9411R-A680
Lokale Artikelnummer::
BOSSBS-9411R-A680
Beschreibung:
TSPAN2 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. TSPAN2 may play a role in Signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1980R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1980R-A647
Lokale Artikelnummer::
BOSSBS-1980R-A647
Beschreibung:
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3958R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3958R-A555
Lokale Artikelnummer::
BOSSBS-3958R-A555
Beschreibung:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1025R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1025R-A647
Lokale Artikelnummer::
BOSSBS-1025R-A647
Beschreibung:
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3669R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3669R-A647
Lokale Artikelnummer::
BOSSBS-3669R-A647
Beschreibung:
Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7974R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7974R-A555
Lokale Artikelnummer::
BOSSBS-7974R-A555
Beschreibung:
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ATX2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. ATX2 is caused by expansion of a CAG repeat in the coding region of ATX2. Longer expansions result in earlier onset of the disease. There are four named isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1256R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1256R-A750
Lokale Artikelnummer::
BOSSBS-1256R-A750
Beschreibung:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1257R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1257R-A350
Lokale Artikelnummer::
BOSSBS-1257R-A350
Beschreibung:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1081R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1081R-A488
Lokale Artikelnummer::
BOSSBS-1081R-A488
Beschreibung:
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13570R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13570R-A488
Lokale Artikelnummer::
BOSSBS-13570R-A488
Beschreibung:
The BTB is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. ZBTB3 (zinc finger and BTB domain containing 3) is a 574 amino acid protein that contains one BTB (POZ) domain and two C2H2-type zinc fingers. Localized to the nucleus, ZBTB3 is thought to play a role in transcriptional regulation events. The gene encoding ZBTB3 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7552R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7552R-A555
Lokale Artikelnummer::
BOSSBS-7552R-A555
Beschreibung:
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex. [provided by RefSeq, Nov 2009]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3268R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3268R-A555
Lokale Artikelnummer::
BOSSBS-3268R-A555
Beschreibung:
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3478R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3478R-A647
Lokale Artikelnummer::
BOSSBS-3478R-A647
Beschreibung:
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6816R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6816R-A350
Lokale Artikelnummer::
BOSSBS-6816R-A350
Beschreibung:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5636R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5636R-A488
Lokale Artikelnummer::
BOSSBS-5636R-A488
Beschreibung:
Synaptotagmins (Syts) are a large gene family of synaptic vesicle integral membrane proteins. Syt functions as regulators of both exocytosis /endocytosis and is involved in neurotransmitter secretion from small secretory vesicles. 13 isoforms of Syt have been identified(SytI-XIII). SynaptotagminVI is localized to the endoplasmic reticulum and/or Golgi like perinuclear compartment. It may be important for trafficking and calcium signaling as it is specially expressed in nonneuronal tissues. Also SytVI is present in the acrosomal region of mammalian spermatozoa. The cytosolic domain of SytVI can abrogate exocytosis by competing with the endogenous protein for essential interactions with the fusion machinery involved in a acrosomal exocytosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3725R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3725R-A350
Lokale Artikelnummer::
BOSSBS-3725R-A350
Beschreibung:
PRKACA and PRKACB are members of the Ser/Thr protein kinase family and are a catalytic subunit of cAMP-dependent protein kinase. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.PKA alpha + beta (catalytic subunits) (phospho Thr198)
VE:
1 * 100 µl
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