(\\u00B1)-1,2-Pentandiol
Lieferant:
Alfa Aesar
Beschreibung:
Ethyl-4-methyl-1,3-oxazol-5-carboxylat ≥97%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Cyclohexylmethylketon 95%
Artikel-Nr:
(BOSSBS-5915R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5915R-CY5
Lokale Artikelnummer::
BOSSBS-5915R-CY5
Beschreibung:
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5915R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5915R-CY3
Lokale Artikelnummer::
BOSSBS-5915R-CY3
Beschreibung:
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
6-Chinolylmethylether 98%
Lieferant:
Alfa Aesar
Beschreibung:
2-(Methylamino)ethanol 99%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Pirfenidone 98%
Artikel-Nr:
(ACRO460400010)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
460400010
Lokale Artikelnummer::
ACRO460400010
Beschreibung:
Methylpalmitoleat 99% analytischer Standard für GC
VE:
1 * 1 g
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
4-Acetylpyridin 97%
Lieferant:
Thermo Scientific
Beschreibung:
Sarkosinsäuremethylester Hydrochlorid 97%
Artikel-Nr:
(BOSSBS-6350R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6350R-A680
Lokale Artikelnummer::
BOSSBS-6350R-A680
Beschreibung:
Lysine methylation occurs in three distinct states, having either one (me1), two (me2) or three (me3) methyl groups attached to the amine group of the lysine side chain. In eukaryotes, histone H3 trimethylated at lysine 4 (H3K4me3) is associated with active chromatin and gene expression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6350R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6350R-A647
Lokale Artikelnummer::
BOSSBS-6350R-A647
Beschreibung:
Lysine methylation occurs in three distinct states, having either one (me1), two (me2) or three (me3) methyl groups attached to the amine group of the lysine side chain. In eukaryotes, histone H3 trimethylated at lysine 4 (H3K4me3) is associated with active chromatin and gene expression.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
Methyloctanoat 99% analytischer Standard für GC
Lieferant:
Merck
Beschreibung:
1-Methylnaphthalin zur Synthese, Sigma-Aldrich®
Lieferant:
Merck
Beschreibung:
4-Picolin zur Synthese, Sigma-Aldrich®
Artikel-Nr:
(8.18795.0025)
Lieferant:
Merck
Hersteller-Artikelnummer::
8.18795.0025
Lokale Artikelnummer::
MERC8.18795.0025
Beschreibung:
2-Decanon zur Synthese, Sigma-Aldrich®
VE:
1 * 25 mL
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
![]()
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
![]()
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
Dieses Produkt ist nicht mehr verfügbar. Bitte kontaktieren Sie den VWR Kundenservice.
|
|||||||||