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LEICA MICROSYSTEMS
Artikel-Nr:
(BOSSBS-3744R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3744R-A488
Lokale Artikelnummer::
BOSSBS-3744R-A488
Beschreibung:
Paxillin is a 64 kDa cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12174R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12174R-A680
Lokale Artikelnummer::
BOSSBS-12174R-A680
Beschreibung:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0224R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0224R-A488
Lokale Artikelnummer::
BOSSBS-0224R-A488
Beschreibung:
Nuclear co-repressor 2 (N-CoR2) gene (NCOR2, previously called silencing mediator for retinoid and thyroid hormone receptor SMRT) is recruited to nuclear and non-nuclear receptors in a large repressing complex containing also N-CoR1, mSin3 and HDACs. This large complex represses transcription in absence of ligand. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Tissue specificity: Ubiquitous. It is belongs to the N-CoR nuclear receptor corepressors family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4165R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4165R-A647
Lokale Artikelnummer::
BOSSBS-4165R-A647
Beschreibung:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12264R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12264R-A488
Lokale Artikelnummer::
BOSSBS-12264R-A488
Beschreibung:
FTSJ1 is a 329 amino acid nucleolar protein belonging to the RlmE family and methyltransferase superfamily. Expressed in adult thalamus, hippocampus, amygdala, corpus callosum and caudate nucleus, as well as fetal kidney, lung, liver, brain and lung, FTSJ1 plays a role in rRNA modification and processing. FTSJ1 exists as multiple spliced isoforms which are encoded by a gene located on human chromosome Xp11.23. Notably, defects in the gene encoding FTSJ1 are the cause of mental retardation X-linked type 44 (MRX44) and nonsyndromic X-linked mental retardation (MRX9).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3412R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3412R-A350
Lokale Artikelnummer::
BOSSBS-3412R-A350
Beschreibung:
The SHC gene encodes for a signaling and transforming protein containing Src homology 2 and 3 (SH2 and SH3) domains. The SHC gene encodes 2 widely expressed overlapping proteins of 46 and 52 kD, both containing a C-terminal SH2 domain. Adjacent to the SH2 region is a glycine and proline rich region. These 2 proteins differ in their N terminals. SHC proteins are involved in mitogenic signal transduction and act by coupling growth factor receptors to the RAS signaling pathway. The protein encoded by the SHC1 gene is thought to act as an adaptor in many signal transduction pathways.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5673R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5673R-A350
Lokale Artikelnummer::
BOSSBS-5673R-A350
Beschreibung:
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6970R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6970R-A488
Lokale Artikelnummer::
BOSSBS-6970R-A488
Beschreibung:
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11789R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11789R-A350
Lokale Artikelnummer::
BOSSBS-11789R-A350
Beschreibung:
The sense of taste provides animals with valuable information about the quality and nutritional value of food. A family of G protein coupled receptors are involved in taste perception and include T1R, which is involved in sweet and umami taste perception and T2R, which is involved in bitter taste perception. Both types of taste receptors couple to various G proteins to initiate signal transduction cascades. T2R49 plays a role in sensing the chemical composition of the gastrointestinal content. T2R49 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2042R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2042R-A750
Lokale Artikelnummer::
BOSSBS-2042R-A750
Beschreibung:
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3586R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3586R-A680
Lokale Artikelnummer::
BOSSBS-3586R-A680
Beschreibung:
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6405R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6405R-A680
Lokale Artikelnummer::
BOSSBS-6405R-A680
Beschreibung:
Get4 is a 327 amino acid cytoplasmic protein that exists as two alternatively spliced isoforms. Get4 forms a multiprotein complex, known as the BAT3 complex, with UBL4A, BAT3 and ARSA. The BAT3 complex plays a role in transporting tail-anchored membrane proteins to the endoplasmic reticulum membrane. The gene encoding Get4 maps to human chromosome 7p22.3. Human chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6043R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6043R-A488
Lokale Artikelnummer::
BOSSBS-6043R-A488
Beschreibung:
NBL1 (Neuroblastoma, suppression of tumorigenicity 1) is a candidate tumor suppressor of neuroblastoma and may play a role in preventing cells from entering the final stage (G1/S) of the transformation process. NBL1 is a member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. It is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11448R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11448R-A350
Lokale Artikelnummer::
BOSSBS-11448R-A350
Beschreibung:
Arylalkylamine N-acetyltransferase belongs to the superfamily of acetyltransferases. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for seasonal reproduction, modulates the function of the circadian clock in the suprachiasmatic nucleus, and influences activity and sleep. This enzyme is rapidly inactivated when animals are exposed to light at night. This protein is 80% identical to sheep and rat AA-NAT. Arylalkylamine N-acetyltransferase may contribute a multifactorial genetic diseases such as altered behavior in sleep/wake cycle.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11799R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11799R-A750
Lokale Artikelnummer::
BOSSBS-11799R-A750
Beschreibung:
TMEM18 is a 140 amino acid multi-pass membrane protein that localizes to the nuclear membrane and is expressed in the brain. TMEM18 functions as a cell migration modulator which enhances the glioma-specific migration ability of neural precursor and neural stem cells. Overexpression of TMEM18 increases migration of human and murine neural stem cells, whereas knockdown of TMEM18 mRNA reduces cellular migration. Two specific single nucleotide polymorphisms (SNPs) within the TMEM18 gene locus known as rs6548238 and rs756131 have been linked to obesity susceptibility.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9577R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9577R-A680
Lokale Artikelnummer::
BOSSBS-9577R-A680
Beschreibung:
TSPEAR, also known as C21orf9, is a 669 amino acid secreted protein. Expressed as two isoforms produced by alternative splicing, TSPEAR contains one Thrombospondin N-terminal domain and seven EAR (epilepsy-associated repeat) domains. EAR domains are found in several proteins, including TSPEAR, encoded by genes that map within chromosome regions associated with seizure disorders. It is thought that the EAR domain plays a role in the pathogenesis of epilepsy by either binding to an unknown epileptic ligand or interfering with axon synaptogenesis.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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