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Methylpyrazolo[1,5-a]pyridin-3-carboxylat
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Methylpyrazolo[1,5-a]pyridin-3-carboxylat
Artikel-Nr:
(BOSSBS-3959R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3959R-A750
Lokale Artikelnummer::
BOSSBS-3959R-A750
Beschreibung:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2382R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2382R-A680
Lokale Artikelnummer::
BOSSBS-2382R-A680
Beschreibung:
Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2880R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2880R-A680
Lokale Artikelnummer::
BOSSBS-2880R-A680
Beschreibung:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2358R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2358R-A680
Lokale Artikelnummer::
BOSSBS-2358R-A680
Beschreibung:
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0481R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0481R
Lokale Artikelnummer::
BOSSBS-0481R
Beschreibung:
Anti-IFNG Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12361R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12361R-HRP
Lokale Artikelnummer::
BOSSBS-12361R-HRP
Beschreibung:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. FLRT1 (fibronectin leucine rich transmembrane protein 1) is a 646 amino acid single-pass type I membrane protein that contains one fibronectin type-III domain and ten LRR repeats. Expressed in kidney and brain, FLRT1 is thought to play a role in cell adhesion and receptor signaling. FLRT1 shares similarity with FLRT2 and FLRT3 and is subject to post-translational N-glycosylation. The gene encoding FLRT1 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7919R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7919R
Lokale Artikelnummer::
BOSSBS-7919R
Beschreibung:
MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uterus.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5767R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5767R-HRP
Lokale Artikelnummer::
BOSSBS-5767R-HRP
Beschreibung:
Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. It is produced in several tissues, including the testis, liver, heart and in certain tumor cells. Epigen is mitogenic for fibroblasts and epithelial cells. Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5731R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5731R-CY7
Lokale Artikelnummer::
BOSSBS-5731R-CY7
Beschreibung:
Mad2L1 is required for the execution of the mitotic checkpoint which monitors the process of kinetochore spindle attachment and delays the onset of anaphase when this process is not complete. It inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4982R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4982R-FITC
Lokale Artikelnummer::
BOSSBS-4982R-FITC
Beschreibung:
HIV1 performs highly complex orchestrated tasks during the assembly, budding, maturation and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. HIV1 Gag p17, the HIV1 matrix protein is produced by the digestion of its precursor Gag p55 by HIV1 protease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2765R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2765R-CY5.5
Lokale Artikelnummer::
BOSSBS-2765R-CY5.5
Beschreibung:
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5511R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5511R-A488
Lokale Artikelnummer::
BOSSBS-5511R-A488
Beschreibung:
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5596R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5596R-FITC
Lokale Artikelnummer::
BOSSBS-5596R-FITC
Beschreibung:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5556R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5556R-FITC
Lokale Artikelnummer::
BOSSBS-5556R-FITC
Beschreibung:
This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7588R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7588R-HRP
Lokale Artikelnummer::
BOSSBS-7588R-HRP
Beschreibung:
Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0033R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0033R
Lokale Artikelnummer::
BOSSBS-0033R
Beschreibung:
Anti-P53 proteinwt-p53 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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