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3,5-Dichloro-4-fluorophenol
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3,5-Dichloro-4-fluorophenol
Artikel-Nr:
(BOSSBS-9248R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9248R-HRP
Lokale Artikelnummer::
BOSSBS-9248R-HRP
Beschreibung:
RNF113A is a novel gene whose function cannot directly be inferred from it's sequence analysis. Ring finger proteins have a role in signalling the destruction of a range of heterologous protein substrates. They are small zinc binding domains present within arrays of larger, functionally distinct proteins, often close to the amino or carboxyl termini. RNF113A is a ubiquitously expressed protein that contains a RING type zinc finger and a C3H1 type zinc finger.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9133R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9133R-A488
Lokale Artikelnummer::
BOSSBS-9133R-A488
Beschreibung:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13249R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13249R-A350
Lokale Artikelnummer::
BOSSBS-13249R-A350
Beschreibung:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13609R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13609R-HRP
Lokale Artikelnummer::
BOSSBS-13609R-HRP
Beschreibung:
Spermatogenesis is the process by which male spermatogonia develop into mature spermatozoa. DAZ (deleted in azoospermia) are RNA-binding proteins that play an essential role in spermatogenesis. DAZ proteins influence the first stages of spermatogenesis and the maintenance of germ cell populations. DAZ proteins (DAZ1, DAZ2, DAZ3, DAZ4 and DAZ5) are encoded by separate genes on chromosome Y, each of which contain an AZFc domain in their coding region. DAZ proteins localize to the nucleus of spermatogonia, but relocate to the cytoplasm during meiosis. DAZ proteins contain an RRM (RNA recognition motif) domain that may regulate mRNA translation by binding to the 3’UTR. Deletions in the genes encoding DAZ proteins may cause azoospermia or oligospermia which can lead to male infertility. DAZ4 (deleted in azoospermia 4), also known as pDP1680 or pDP1681, is a 579 amino acid testis specific protein that contains nine DAZ-like domains and two RNA recognition motifs (RRM). DAZ4 exists as two alternatively spliced isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3541R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3541R-FITC
Lokale Artikelnummer::
BOSSBS-3541R-FITC
Beschreibung:
Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4523R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4523R-A647
Lokale Artikelnummer::
BOSSBS-4523R-A647
Beschreibung:
FMDV Polyprotein (VPg2 protein)
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3532R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3532R-A647
Lokale Artikelnummer::
BOSSBS-3532R-A647
Beschreibung:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3261R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3261R-CY5
Lokale Artikelnummer::
BOSSBS-3261R-CY5
Beschreibung:
Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA, HSF1, HSP27/HSPB1, KRT18, KRT2, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3253R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3253R-A647
Lokale Artikelnummer::
BOSSBS-3253R-A647
Beschreibung:
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2914R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2914R-FITC
Lokale Artikelnummer::
BOSSBS-2914R-FITC
Beschreibung:
Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3294R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3294R-A350
Lokale Artikelnummer::
BOSSBS-3294R-A350
Beschreibung:
Protein which catalyzes the phosphorylation of serine or threonine residues on target proteins by using ATP as phosphate donor. Such phosphorylation may cause changes in the function of the target protein. Protein kinases share a conserved catalytic core common to both serine/ threonine and tyrosine protein kinases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3055R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3055R-HRP
Lokale Artikelnummer::
BOSSBS-3055R-HRP
Beschreibung:
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3958R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3958R-A647
Lokale Artikelnummer::
BOSSBS-3958R-A647
Beschreibung:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2533R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2533R-CY5.5
Lokale Artikelnummer::
BOSSBS-2533R-CY5.5
Beschreibung:
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2493R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2493R-A350
Lokale Artikelnummer::
BOSSBS-2493R-A350
Beschreibung:
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13265R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13265R-A555
Lokale Artikelnummer::
BOSSBS-13265R-A555
Beschreibung:
GALE is a 348 amino acid protein that functions as the third enzyme in the Leloir pathway of galactose metabolism. A member of the sugar epimerase family, GALE exists as a homodimer, binds FAD as a cofactor and catalyzes the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine and UDP-glucose to UDP-galactose. The gene encoding GALE maps to human chromosome 1p36.11 and mutations in this gene lead to the development of complex disorder known as epimerase-deficiency galactosemia (EDG) or galactosemia type 3, which is characterized by mental retardation, liver damage, cataracts and deafness.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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