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1-Boc-3-indolboronsäurepinakolester
Artikel-Nr:
(BOSSBS-13235R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13235R-CY3
Lokale Artikelnummer::
BOSSBS-13235R-CY3
Beschreibung:
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9957R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9957R-A750
Lokale Artikelnummer::
BOSSBS-9957R-A750
Beschreibung:
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. CREG (cellular repressor of E1A-stimulated genes) is a cellular protein that antagonizes transcriptional activation and cellular transformation by E1A. CREG was initially isolated in a yeast two-hybrid screen due to its interaction with the TATA-binding protein, TBP. A member of the CREG family, CREG2 (cellular repressor of E1A-stimulated genes 2) is a novel protein that shares 35% homology with CREG and is expressed at highest levels in brain. CREG2 is a secreted protein containing 290 amino acids whose N-terminus is thought to function as a signal sequence. The gene encoding CREG2 maps to human chromosome 2, which consists of 237 million bases, encodes over 1400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12883R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12883R
Lokale Artikelnummer::
BOSSBS-12883R
Beschreibung:
The breast cancer susceptibility gene (BRCA1) localizes to chromosome 17q. Mutations within this gene account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast cancer, but unlike BRCA1, BRCA2 does not confer a substantially elevated risk of ovarian cancer. The BRCA2-Associated Factor 35 (BRAF35) protein forms a complex with BRCA2, which associates with condensed chromatin during histone H3 phosphorylation. BRAF35 expression levels are highest in proliferating tissues and parallel BRCA2 expression patterns. The structure of BRAF35 includes a kinesin-like coiled coil domain and a nonspecific DNA binding HMG domain. The chromatin localization of BRAF35 and antibody microinjection studies indicate a role for the BRAF35/BRCA2 complex in cell cycle regulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13202R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13202R-A680
Lokale Artikelnummer::
BOSSBS-13202R-A680
Beschreibung:
Xenopus winged-helix factor, xFAST-1 (forkhead activin signal transducer-1) is a transcription factor that forms a complex with the receptor-regulated Smad protein, Smad2, and directly binds to activin response elements on DNA (1,2). The human homolog FAST-1 and the corresponding mouse homolog, designated FAST-2, share significant sequence homology with xFAST-1, including a conserved N-terminal forkhead domain that consists of 110 amino acid residues and is essential for binding DNA and regulating transcription in embryogenesis, in tumorigenesis and in the maintenance of differentiated cell states (3,4). FAST-1 and FAST-2 also contain a distinct C-terminal Smad interaction domain that is required for the association with various Smad proteins, including Smad2, Smad3 and Smad4 (3,5). Expression of FAST-1 and FAST-2 is predominantly observed during early development, with lower levels detected in adult tissues (6,7). FAST-1 and FAST-2 mediated DNA binding is attenuated by both TFGß and activin, indicating that these FAST proteins mediate TFGß induced signal transduction (3).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13202R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13202R-FITC
Lokale Artikelnummer::
BOSSBS-13202R-FITC
Beschreibung:
Xenopus winged-helix factor, xFAST-1 (forkhead activin signal transducer-1) is a transcription factor that forms a complex with the receptor-regulated Smad protein, Smad2, and directly binds to activin response elements on DNA (1,2). The human homolog FAST-1 and the corresponding mouse homolog, designated FAST-2, share significant sequence homology with xFAST-1, including a conserved N-terminal forkhead domain that consists of 110 amino acid residues and is essential for binding DNA and regulating transcription in embryogenesis, in tumorigenesis and in the maintenance of differentiated cell states (3,4). FAST-1 and FAST-2 also contain a distinct C-terminal Smad interaction domain that is required for the association with various Smad proteins, including Smad2, Smad3 and Smad4 (3,5). Expression of FAST-1 and FAST-2 is predominantly observed during early development, with lower levels detected in adult tissues (6,7). FAST-1 and FAST-2 mediated DNA binding is attenuated by both TFGß and activin, indicating that these FAST proteins mediate TFGß induced signal transduction (3).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13202R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13202R-A555
Lokale Artikelnummer::
BOSSBS-13202R-A555
Beschreibung:
Xenopus winged-helix factor, xFAST-1 (forkhead activin signal transducer-1) is a transcription factor that forms a complex with the receptor-regulated Smad protein, Smad2, and directly binds to activin response elements on DNA (1,2). The human homolog FAST-1 and the corresponding mouse homolog, designated FAST-2, share significant sequence homology with xFAST-1, including a conserved N-terminal forkhead domain that consists of 110 amino acid residues and is essential for binding DNA and regulating transcription in embryogenesis, in tumorigenesis and in the maintenance of differentiated cell states (3,4). FAST-1 and FAST-2 also contain a distinct C-terminal Smad interaction domain that is required for the association with various Smad proteins, including Smad2, Smad3 and Smad4 (3,5). Expression of FAST-1 and FAST-2 is predominantly observed during early development, with lower levels detected in adult tissues (6,7). FAST-1 and FAST-2 mediated DNA binding is attenuated by both TFGß and activin, indicating that these FAST proteins mediate TFGß induced signal transduction (3).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13234R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13234R-A555
Lokale Artikelnummer::
BOSSBS-13234R-A555
Beschreibung:
The mammalian FXYD family maintains Na+ and K+ gradients between the intracellular and extracellular milieus of cells in processes such as renal Na+-reabsorption, muscle contraction and neuronal excitability. FXYDs are single-span membrane proteins that share a 35 amino acid signature domain, beginning with the sequence PFXYD and containing seven invariant and six conserved amino acids. Members of the FXYD family include FXYD1 (PLM, phospholemman), FXYD2 (the g subunit of the Na+/K+-ATPase), FXYD3 (Mat8, mammary tumor protein), FXYD4 (CHIF) and FXYD5 (RIC). FXYD6 is expressed in various epithelial cells bordering the endolymph space and in the auditory neurons. FXYD6 co-localizes with Na+/K+-ATPase in the stria vascularis and can be co-immunoprecipitated with Na+/K+-ATPase. After expression, FXYD6 associates with Na+/K+-ATPase alpha1-beta1 and alpha1-beta2 isozymes, which are preferentially expressed in different regions of the inner ear and also with gastric and non-gastric H+/K+-ATPase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13235R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13235R-CY7
Lokale Artikelnummer::
BOSSBS-13235R-CY7
Beschreibung:
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13235R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13235R-A488
Lokale Artikelnummer::
BOSSBS-13235R-A488
Beschreibung:
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13235R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13235R-A555
Lokale Artikelnummer::
BOSSBS-13235R-A555
Beschreibung:
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13202R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13202R-A350
Lokale Artikelnummer::
BOSSBS-13202R-A350
Beschreibung:
Xenopus winged-helix factor, xFAST-1 (forkhead activin signal transducer-1) is a transcription factor that forms a complex with the receptor-regulated Smad protein, Smad2, and directly binds to activin response elements on DNA (1,2). The human homolog FAST-1 and the corresponding mouse homolog, designated FAST-2, share significant sequence homology with xFAST-1, including a conserved N-terminal forkhead domain that consists of 110 amino acid residues and is essential for binding DNA and regulating transcription in embryogenesis, in tumorigenesis and in the maintenance of differentiated cell states (3,4). FAST-1 and FAST-2 also contain a distinct C-terminal Smad interaction domain that is required for the association with various Smad proteins, including Smad2, Smad3 and Smad4 (3,5). Expression of FAST-1 and FAST-2 is predominantly observed during early development, with lower levels detected in adult tissues (6,7). FAST-1 and FAST-2 mediated DNA binding is attenuated by both TFGß and activin, indicating that these FAST proteins mediate TFGß induced signal transduction (3).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11604R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11604R
Lokale Artikelnummer::
BOSSBS-11604R
Beschreibung:
Na+/Cl- dependent neurotransmitter transporters are a superfamily of transmembrane proteins that contain 12 membrane spanning regions (1). Specifically, the highly hydrophobic Na+/Cl- dependent glycine transporters (GlyT) are crucial for the termination of neurotransmission at glycinergic synapses (2,3). Two different GlyT genes encode GlyT2 and GlyT1, which exists as two isoforms produced by alternative splicing of the same gene located on human chromosome 1p31.3 (3,4). The GlyT1 gene may be an early marker of neural development and encodes glia-specific transporter proteins (3). Although GlyT1 and GlyT2 are both expressed in the brain and spinal cord, each shows a unique pattern of expression (3,5,6). GlyT1 is found only in the white matter of the CNS, whereas GlyT2 is found in the gray matter of the CNS as well as in macrophages and mast cells in peripheral tissues (3,5). The anatomic distribution of GlyT2 mRNA suggests that glycine may act as a supraspinal neurotransmitter and may function as a chemical messenger outside the CNS (5).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7919R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7919R
Lokale Artikelnummer::
BOSSBS-7919R
Beschreibung:
MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uterus.
VE:
1 * 100 µl
Lieferant:
THERMO HYBAID
Beschreibung:
Rotisserie, 35 mm clips, 14 positions
Artikel-Nr:
(91117.001)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC91117.001
Beschreibung:
A standard mixture, typically used for food testing, containing the following components: 100 ug/ml each of Atrazine [CAS:1912-24-9] ; Bupirimate [CAS:41483-43-6] ; Captafol [CAS:2425-06-1] ; Captan [CAS:133-06-2] ; Chlorfenapyr [CAS:122453-73-0] ; Cyprodinil [CAS:121552-61-2] ; Etofenprox [CAS:80844-07-1] ; Etridiazole [CAS:2593-15-9] ; Fenarimol [CAS:60168-88-9] ; Fipronil [CAS:120068-37-3] ; Fludioxonil [CAS:131341-86-1] ; Fluridone [CAS:59756-60-4] ; Flusilazole [CAS:85509-19-9] ; Flutriafol [CAS:76674-21-0] ; Folpet [CAS:133-07-3] ; Hexazinone [CAS:51235-04-2] ; Iprodione [CAS:36734-19-7] ; Lenacil [CAS:2164-08-1] ; MGK 264 [CAS:113-48-4] ; Myclobutanil [CAS:88671-89-0] ; Paclobutrazol [CAS:76738-62-0] ; Penconazole [CAS:66246-88-6] ; Procymidone [CAS:32809-16-8] ; Propargite [CAS:2312-35-8] ; Pyrimethanil [CAS:53112-28-0] ; Pyriproxyfen [CAS:95737-68-1] ; Tebuconazole [CAS:107534-96-3] ; Terbacil [CAS:5902-51-2] ; Terbuthylazine [CAS:5915-41-3] ; Triadimefon [CAS:43121-43-3] ; Triadimenol [CAS:55219-65-3] ; Tricyclazole [CAS:41814-78-2] ; Triflumizole [CAS:68694-11-1] ; Vinclozolin [CAS:50471-44-8] in Toluene
VE:
1 * 1 mL
Artikel-Nr:
(PROOCIL-PCB-159)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
CIL-PCB-159
Lokale Artikelnummer::
PROOCIL-PCB-159
Beschreibung:
Organic Standard, 2,3,3',4,5,5'-Hexachlorbiphenyl (PCB Nr. 159) 35 µg/ml in Isooctan, Packung: Glasflasche
VE:
1 * 1 mL
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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