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3,6-Difluorphthalsäureanhydrid
Lieferant:
Biotium
Beschreibung:
This monoclonal antibody is part of a new panel of reagents, which recognizes subcellular organelles or compartments of human cells. These markers may be useful in identification of these organelles in cells, tissues, and biochemical preparations. This MAb recognizes the double stranded DNA in human cells. It can be used to stain the nuclei in cell or tissue preparations and can be used as a nuclear marker in human cells. This MAb produces a homogeneous staining pattern in the nucleus of normal and malignant cells.,Deoxyribonucleic acid (DNA) is a long polymer of nucleotides that is held together by a backbone made of sugars and phosphate groups. It holds the genetic instructions for the development and function of living things. DNA is crucial for living organisms, and all known cellular life and some viruses contain DNA. In eukaryotes, DNA exists in the cell nucleus, while in prokaryotes; DNA is located in the cytoplasm. In living organisms, DNA does not usually exist as a single molecule, but instead as a tightly associated pair of molecules in the shape of a right-handed double helix. Hydrogen bonds as well as forces generated by the hydrophobic effect and pi stacking hold the two DNA strands together. During replication and transcription, portions of the helix unwind and become single stranded. Protective proteins surround these single-stranded DNA. Double stranded (ds) DNA markers are useful tools in biology research and aid in the study of DNA behavior and characteristics.
Artikel-Nr:
(BOSSBS-11670R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11670R-A680
Lokale Artikelnummer::
BOSSBS-11670R-A680
Beschreibung:
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumour suppressor genes (TSGs) or other tumour-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumour suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.
VE:
1 * 100 µl
Lieferant:
LABCON
Beschreibung:
ProtectR® tube is the only container closure system engineered to be CO₂ resistant and stop costly damage to molecular and cellular solutions when using dry ice. Made of durable, high-quality materials and fitted with an air-tight cap, ProtectR® Tubes form a protective barrier impermeable to CO₂, keeping the sample pH stable and preventing acidification.
Lieferant:
UVEX
Beschreibung:
Die Super OTG verfügt über scharnierlose Bügel aus Grilamid. Sie vereint die Vorteile der Bügelbrille mit den Trageeigenschaften von Kopfbändern.
Lieferant:
Deb-STOKO
Beschreibung:
Vielseitige Hautcreme (O/W-Emulsion) zum Schutz für empfindliche Haut, die wechselnden und unterschiedlichen Belastungen ausgesetzt ist. Auch unter Handschuhen anwendbar. Das Produkt schützt sowohl gegen rein ölige als auch wassermischbare oder wässrige Arbeitsstoffe. Ideal für Aktivitäten in verschiedenen Arbeitsbereichen.
Artikel-Nr:
(111-2170)
Lieferant:
DRAEGER
Hersteller-Artikelnummer::
R59431
Lokale Artikelnummer::
DRAER59431
Beschreibung:
Diese kombinierte Brand- und Industriefluchthaube wurde gemeinsam mit Anwendern und im Hinblick auf eine möglichst schnelle Flucht entwickelt. Der optimierte Bedien- und Tragekomfort, das stabile Gehäuse und der geprüfte ABEK P3 Filter schützen mindestens 15 Minuten vor toxischen Industriegasen, Dämpfen und Partikeln.
VE:
1 * 1 ST
Artikel-Nr:
(CORN6078)
Lieferant:
Corning
Hersteller-Artikelnummer::
6078
Lokale Artikelnummer::
CORN6078
Beschreibung:
Enrty module power on/off switch with overload protection
VE:
1 * 1 Pack.
Lieferant:
MENSCH FRANZ
Beschreibung:
Diese HACCP-konforme Einweg-Kittel aus PP-Vlies schützt hygiene-sensible Bereiche vor Verunreinigungen und ist besonders leicht und atmungsaktiv.
Lieferant:
UVEX
Beschreibung:
Die ultraleichte Bügelbrille aus Hightech-Polymer verfügt über eine robuste Fassung und ein neuentwickeltes Bügelkonzept mit angenehm weichen, flexiblen Bügeln. Die Super G gewährleistet einen komfortablen, druckfreien Sitz für ermüdungsfreies Arbeiten.
Lieferant:
SIOEN PERSONAL PROTECTIVE CLOT
Beschreibung:
Schützende, zweifarbige Jacke aus 100 % weichem, doppelseitigem Polyester-Fleece für einen guten Schutz vor Kälte. Mit Antipilling-Behandlung und Saumnähten. Kann mit einem Reißverschluss in die Regenjacke 608Z eingesetzt werden.
Artikel-Nr:
(BOSSBS-5130R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5130R-A750
Lokale Artikelnummer::
BOSSBS-5130R-A750
Beschreibung:
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognises the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1359R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1359R-HRP
Lokale Artikelnummer::
BOSSBS-1359R-HRP
Beschreibung:
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5650R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5650R-CY5.5
Lokale Artikelnummer::
BOSSBS-5650R-CY5.5
Beschreibung:
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.
VE:
1 * 100 µl
Lieferant:
MAPA
Beschreibung:
These knitted gloves with insulating lining and Nitrile GRIP & PROOF coating on palm and fingertips provide protection in cold environment down to −10 °C while maintaining comfort, dexterity and flexibility.
Lieferant:
CENTURION SAFETY PRODUCTS
Beschreibung:
Der Concept Roofer ist ein leichter, strapazierfähiger und bequemer Helm aus ABS.
Lieferant:
Corning
Beschreibung:
These multi-barrier filter pipette tips offer the ultimate in protection against cross contamination using tri-filter technology. These tips will prevent liquid or aerosol from passing through and will lock on contact assuring the valuable samples and research have not been compromised.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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