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BIOSS INC
Artikel-Nr:
(BOSSBS-0836R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0836R-FITC
Lokale Artikelnummer::
BOSSBS-0836R-FITC
Beschreibung:
Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3348R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3348R-CY5
Lokale Artikelnummer::
BOSSBS-3348R-CY5
Beschreibung:
PSD 93 is believed to participate in the clustering of certain proteins, including N-methyl-D-aspartate (NMDA) receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD 93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with PSD 93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD 93 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7713R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7713R
Lokale Artikelnummer::
BOSSBS-7713R
Beschreibung:
MIS12 is part of a complex that plays an essential role in chromosome segregation in vertebrates and contributes to mitotic kinetochore assembly.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8686R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8686R-HRP
Lokale Artikelnummer::
BOSSBS-8686R-HRP
Beschreibung:
Breast cancer metastasis-suppressor 1 (BRMS1) is 246 amino acid protein that acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NF-â…¹B activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10280R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10280R-CY7
Lokale Artikelnummer::
BOSSBS-10280R-CY7
Beschreibung:
Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9814R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9814R-A680
Lokale Artikelnummer::
BOSSBS-9814R-A680
Beschreibung:
The second largest human chromosome, 2 consists of 237 million bases encoding over 1400 genes and making up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes seen in modern form today in apes. The C2orf44 gene product has been provisionally designated C2orf44 pending further characterisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11430R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11430R-A680
Lokale Artikelnummer::
BOSSBS-11430R-A680
Beschreibung:
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of Signalling molecules, such as hormones and neurotransmitters. GPR154 (G-protein coupled receptor 154), also known as NPSR1 (neuropeptide S receptor), GPRA (G-protein coupled receptor for asthma susceptibility) or PGR14, is a 371 amino acid protein that is thought to play a role in autocrine or paracrine Signalling pathways. Ubiquitously expressed, GPR154 exists as nine alternatively spliced isoforms. Defects in the gene encoding GPR154 is the cause of asthma-related traits type 2 (ASRT2).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1389R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1389R-CY5
Lokale Artikelnummer::
BOSSBS-1389R-CY5
Beschreibung:
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5650R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5650R-A750
Lokale Artikelnummer::
BOSSBS-5650R-A750
Beschreibung:
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3234R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3234R-A488
Lokale Artikelnummer::
BOSSBS-3234R-A488
Beschreibung:
Nuclear factor kappa B (NFkB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NFkB mediates the expression of a great variety of genes in response to extracellular stimuli including IL1, TNF alpha, and bacterial product LPS. NFkB is associated with IkB proteins in the cell cytoplasm, which inhibit NFkB activity. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta). IKK alpha and IKK beta interact with each other and both are essential for NFkB activation. IKK alpha specifically phosphorylates IkBa. IKKa is expressed in variety of human tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15085R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15085R-A350
Lokale Artikelnummer::
BOSSBS-15085R-A350
Beschreibung:
C1QTNF9
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5284R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5284R-HRP
Lokale Artikelnummer::
BOSSBS-5284R-HRP
Beschreibung:
Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15052R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15052R-HRP
Lokale Artikelnummer::
BOSSBS-15052R-HRP
Beschreibung:
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf194 gene product has been provisionally designated C1orf194 pending further characterisation. There are two isoforms of C1orf194 that are produced as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15243R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15243R-CY5
Lokale Artikelnummer::
BOSSBS-15243R-CY5
Beschreibung:
Making up nearly 6% of the human genome, chromosome 6 contains around 1200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf225 gene product has been provisionally designated C6orf225 pending further characterisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1504R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1504R-FITC
Lokale Artikelnummer::
BOSSBS-1504R-FITC
Beschreibung:
Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localisation to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1567R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1567R-A680
Lokale Artikelnummer::
BOSSBS-1567R-A680
Beschreibung:
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.
VE:
1 * 100 µl
Preis auf Anfrage
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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