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(R)-Methyl+4,4-difluoropyrrolidine-2-carboxylate+hydrochloride
Artikel-Nr:
(BOSSBS-13472R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13472R-A555
Lokale Artikelnummer::
BOSSBS-13472R-A555
Beschreibung:
GTPases from the MMR1/HSR1 GTP-binding protein subfamily are circularly rearranged G-motifs that play a critical role in maintaining normal cell growth. Deletion of these genes results in severe growth defects with a marked reduction in mature rRNA species and a concomitant accumulation of the 35S pre-rRNA transcript. Deletion also causes the ribosomal protein Rpl25a to fail exportation from the nucleolus. Deletion of any of the G-domain motifs will result in a null phenotype and nuclear/nucleolar localization that lacks the nucleolar export of preribosomes and is accompanied by a distortion of the nucleolar structure. GNL3L (guanine nucleotide binding protein-like 3 (nucleolar)-like) is a 582 amino acid nuclear protein that belongs to the MMR1/HSR1 GTP-binding protein family. Containing one G (guanine nucleotide-binding) domain, GNL3L is required for normal processing of ribosomal pre-rRNA and for cell proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9084R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9084R-A555
Lokale Artikelnummer::
BOSSBS-9084R-A555
Beschreibung:
Belonging to the F-box family of proteins, FBXO35 (F-box only protein 35), also designated F-box and WD-40 domain-containing protein 12 (FBXW12 or FBXO12), is a 464 amino acid protein that contains one C-terminal F-box domain. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein)-type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular mechanisms, including the cell cycle, the immune response, signaling cascades and developmental processes. They function by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO35 can directly interact with Skp1 p19 and CUL-1. FBXO35 is ubiquitously expressed at low levels in most human tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13472R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13472R-A488
Lokale Artikelnummer::
BOSSBS-13472R-A488
Beschreibung:
GTPases from the MMR1/HSR1 GTP-binding protein subfamily are circularly rearranged G-motifs that play a critical role in maintaining normal cell growth. Deletion of these genes results in severe growth defects with a marked reduction in mature rRNA species and a concomitant accumulation of the 35S pre-rRNA transcript. Deletion also causes the ribosomal protein Rpl25a to fail exportation from the nucleolus. Deletion of any of the G-domain motifs will result in a null phenotype and nuclear/nucleolar localization that lacks the nucleolar export of preribosomes and is accompanied by a distortion of the nucleolar structure. GNL3L (guanine nucleotide binding protein-like 3 (nucleolar)-like) is a 582 amino acid nuclear protein that belongs to the MMR1/HSR1 GTP-binding protein family. Containing one G (guanine nucleotide-binding) domain, GNL3L is required for normal processing of ribosomal pre-rRNA and for cell proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9617R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9617R
Lokale Artikelnummer::
BOSSBS-9617R
Beschreibung:
C14orf174, is a 674 amino acid protein that contains one SAM (sterile alpha motif) domain. Existing as two alternatively spliced isoforms,C14orf174 is encoded by a gene that maps to human chromosome 14q24.3. Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein Bcl-3 in the (14;19) translocations found in a variety of B cell malignancies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9084R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9084R-A350
Lokale Artikelnummer::
BOSSBS-9084R-A350
Beschreibung:
Belonging to the F-box family of proteins, FBXO35 (F-box only protein 35), also designated F-box and WD-40 domain-containing protein 12 (FBXW12 or FBXO12), is a 464 amino acid protein that contains one C-terminal F-box domain. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein)-type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular mechanisms, including the cell cycle, the immune response, signaling cascades and developmental processes. They function by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO35 can directly interact with Skp1 p19 and CUL-1. FBXO35 is ubiquitously expressed at low levels in most human tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13472R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13472R-CY7
Lokale Artikelnummer::
BOSSBS-13472R-CY7
Beschreibung:
GTPases from the MMR1/HSR1 GTP-binding protein subfamily are circularly rearranged G-motifs that play a critical role in maintaining normal cell growth. Deletion of these genes results in severe growth defects with a marked reduction in mature rRNA species and a concomitant accumulation of the 35S pre-rRNA transcript. Deletion also causes the ribosomal protein Rpl25a to fail exportation from the nucleolus. Deletion of any of the G-domain motifs will result in a null phenotype and nuclear/nucleolar localization that lacks the nucleolar export of preribosomes and is accompanied by a distortion of the nucleolar structure. GNL3L (guanine nucleotide binding protein-like 3 (nucleolar)-like) is a 582 amino acid nuclear protein that belongs to the MMR1/HSR1 GTP-binding protein family. Containing one G (guanine nucleotide-binding) domain, GNL3L is required for normal processing of ribosomal pre-rRNA and for cell proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6514R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6514R-A350
Lokale Artikelnummer::
BOSSBS-6514R-A350
Beschreibung:
CGI-99 is a 244 amino acid protein that localizes to the nucleus, as well as to the cytoplasm, and belongs to the UPF0568 family. Expressed in a variety of tissues with particularly high levels in heart and skeletal muscle, CGI-99 functions as a homodimer that interacts with Ninein and is thought to regulate Ninein function. CGI-99 is overexpressed in brain tumor tissue, suggesting a role in tumor development and metastasis. The gene encoding CGI-99 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.
VE:
1 * 100 µl
Artikel-Nr:
(SIAL263362-5G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
263362-5G
Lokale Artikelnummer::
SIAL263362-5G
Beschreibung:
3',5'-Bis(trifluormethyl)acetophenon, Sigma-Aldrich®
VE:
1 * 5 g
Artikel-Nr:
(SIALA1757-5G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
A1757-5G
Lokale Artikelnummer::
SIALA1757-5G
Beschreibung:
6-Azauracil, Sigma-Aldrich®
VE:
1 * 5 g
Artikel-Nr:
(454-3050)
Lieferant:
ISOPAD
Hersteller-Artikelnummer::
068430-000
Lokale Artikelnummer::
ISOP068430-000
Beschreibung:
Temperaturfühler, −80...+250 °C, 2,0 m (connecting bend), Ø×L: 3,5×50 mm
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-9741R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9741R-HRP
Lokale Artikelnummer::
BOSSBS-9741R-HRP
Beschreibung:
ANGEL1 , also known as KIAA0759, is a 670 amino acid protein belonging to the CKR-4 protein family. ANGEL1 is encoded by a gene located on human chromosome 14, which contains about 700 genes and 106 million base pairs, making up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus on chromosome 14 and its fusion via translocation with the chromosome 19 encoded protein BCL3 may be related to B-cell malignancies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11733R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11733R-A488
Lokale Artikelnummer::
BOSSBS-11733R-A488
Beschreibung:
Myotubularin and the myotubularin-related proteins (MTMR1-9) belong to a highly conserved family of eukaryotic phosphatases. They are protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as substrates. MTMR family members hydrolyze both Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2. MTMR2 interacts with MTMR5, an inactive family member that increases the enzymatic activity of MTMR2 and dictates its subcellular localization. Mutations in MTMR2 cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), which is characterized by reduced nerve conduction velocities, focally folded myelin sheaths and demyelination. MTMR3 and MTMR4 can either interact with each other or self associate. MTMR6 regulates the activity of the calcium-activated potassium channel 3.1. MTMR9 regulates the activity of MTMR7 and MTMR8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11861R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11861R-FITC
Lokale Artikelnummer::
BOSSBS-11861R-FITC
Beschreibung:
HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington’s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.
VE:
1 * 100 µl
Artikel-Nr:
(461-0886)
Lieferant:
JULABO GmbH
Hersteller-Artikelnummer::
9012704
Lokale Artikelnummer::
JULA9012704
Beschreibung:
Die leistungsstarken und robusten CORIO™ Labor-Umwälzthermostate bieten exakte Temperaturen, absolute Präzision und einen breiten Arbeitstemperaturbereich. Das CORIO™ CD-Modell ist ein fortschrittliches Gerät mit professioneller Technik für anspruchsvolle Anwendungen und kann für die Temperierung interner und externer Anwendungen verwendet werden. Die Strahldüse ermöglicht eine stufenlose Anpassung des Pumpenstrahls im System. Die isolierten Edelstahlbäder sind langlebig und verfügen über einen integrierten Ablaufhahn. Diese Wärme-/Kältethermostate eignen sich ideal für die Temperierung von Proben im Thermostatenbad oder für externe Temperieraufgaben. Zum Beispiel: Messzellen, Refraktometer, Polarimeter, Photometer, Viskosimeter, Fermenter, Elektrophoresekammern, Chromatographiesäulen, Rotationsverdampfer und Rheometer.
VE:
1 * 1 ST
Artikel-Nr:
(PROOCIL-PCB-39)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
CIL-PCB-39
Lokale Artikelnummer::
PROOCIL-PCB-39
Beschreibung:
Organic Standard, 3,4',5-Trichlorbiphenyl (PCB Nr. 39) 35 µg/ml in Isooctan, Packung: Glasflasche
VE:
1 * 1 mL
Artikel-Nr:
(PROOCIL-PCB-37)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
CIL-PCB-37
Lokale Artikelnummer::
PROOCIL-PCB-37
Beschreibung:
Organic Standard, 3,4,4'-Trichlorbiphenyl (PCB Nr. 37) 35 µg/ml in Isooctan, Packung: Glasflasche
VE:
1 * 1 mL
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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