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4-Cyano-3-fluorobenzoic+acid
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4-Cyano-3-fluorobenzoic+acid
Artikel-Nr:
(BNUM0191-50)
Lieferant:
Biotium
Hersteller-Artikelnummer::
BNUM0191-50
Lokale Artikelnummer::
BTIUBNUM0191-50
Beschreibung:
Recognizes a phosphor-protein of 45 kDa, identified as MyoD1. The epitope of this MAb maps between amino acid 180-189 in the C-terminal of mouse MyoD1 protein. It does not cross react with myogenin, Myf5, or Myf6. Antibody to MyoD1 labels the nuclei of myoblasts in developing muscle tissues. MyoD1 is not detected in normal adult tissue, but is highly expressed in the tumor cell nuclei of rhabdomyosarcomas. Occasionally nuclear expression of MyoD1 is seen in ectomesenchymoma and a subset of Wilm s tumors. Weak cytoplasmic staining is observed in several non-muscle tissues, including glandular epithelium and also in rhabdomyosarcomas, neuroblastomas, Ewing s sarcomas and alveolar soft part sarcomas.
VE:
1 * 50 µl
Artikel-Nr:
(BOSSBS-4009R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4009R-A488
Lokale Artikelnummer::
BOSSBS-4009R-A488
Beschreibung:
Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11438R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11438R-A555
Lokale Artikelnummer::
BOSSBS-11438R-A555
Beschreibung:
Thyroid hormone receptors (TRs) are transcription factors that regulate the expression of specific genes in a hormone-dependent manner. TRIP13 is a transcription factor that interacts with the ligand binding domain of the thyroid receptor (TR) as well as a variety of target genes including human papilloma virus type 16 (HPV16) E1. Unlike most TRIP proteins which function only in the presence of hormones, TRIP13 does not require the presence of thyroid hormone to interact with TR. The association of TRIP13 with (HPV16) E1 suggests that TRIP13 may have tumor suppressor gene function. TRIP13 is a 432 amino acid protein with 2 different isoforms produced by alternative splicing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11459R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11459R-A647
Lokale Artikelnummer::
BOSSBS-11459R-A647
Beschreibung:
FARP2 is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism.
VE:
1 * 100 µl
Lieferant:
ELTEN
Beschreibung:
Safety shoe, NELSON XXG GTX, lace-up in black finish.
Artikel-Nr:
(BOSSBS-8261R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8261R-HRP
Lokale Artikelnummer::
BOSSBS-8261R-HRP
Beschreibung:
DHRS13 (dehydrogenase/reductase SDR family member 13), also known as UNQ419/PRO853, is a 377 amino acid secreted protein belonging to the short-chain dehydrogenases/reductases (SDR) family. DHRS13 is presumed to function as an oxidoreductase and is phosphorylated, potentially by ATM or ATR, upon DNA damage. DHRS13 exists as two isoforms produced by alternative splicing events. The gene encoding DHRS13 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Neurofibromatosis, dysregulated Schwann cell growth, Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are associated with chromosome 17.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9628R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9628R-A750
Lokale Artikelnummer::
BOSSBS-9628R-A750
Beschreibung:
C16orf44 is a 616 amino acid protein that contains six Kelch repeats, one BTB/POZ domain and one BTB/Kelch associated (BACK) domain. C16orf44 is believed to play a role in protein ubiquitination and may function as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, C16orf44 interacts with CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Due to alternative splicing events, two isoforms of C16orf44 are expressed.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11873R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11873R-HRP
Lokale Artikelnummer::
BOSSBS-11873R-HRP
Beschreibung:
Lingo-4 is a 593 amino acid single-pass type I membrane protein that contains eleven LRR (leucine-rich) repeats, one Ig-like C2-type (immunoglobulin-like) domain, one LRRCT domain and one LRRNT domain. The gene that encodes Lingo-4 consists of approximately 5,891 bases and maps to human chromosome 1q21.3. Comprising nearly 8% of the human genome, chromosome 1 spans 260 million base pairs, contains over 3,000 genes and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8032R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8032R-FITC
Lokale Artikelnummer::
BOSSBS-8032R-FITC
Beschreibung:
COLEC11 is a 271 amino acid C-type lectin protein that contains a collagen-like domain and a carbohydrate recognition domain, and plays an important role in host-defense. COLEC11 binds to various sugars and LPS (lipopolysaccharides), which include fucose but does not bind to glucose, hnRNP, Beta-1,3-Gal-T3 or mannose. COLEC11 is ubiquitously expressed in most tissues with high expression in kidney, liver, fetal liver, small intestine, thymus, spinal cord, placenta, adrenal gland, pancreas and several cell lines. COLEC11 is a secreted protein and all alternatively spliced isoforms of COLEC11 have oligomeric structures created through disulfide bonding.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8293R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8293R-A680
Lokale Artikelnummer::
BOSSBS-8293R-A680
Beschreibung:
DQX1 (DEAQ box RNA-dependent ATPase 1), also known as FLJ23757, is a 71 amino acid protein that contains one helicase ATP-binding domain and one helicase C-terminal domain. Localised to the nucleus, DQX1 catalyzes the conversion of ATP to ADP and a phosphate. Expressed as three isoforms produced by alternative splicing events, DQX1 is encoded by a gene that maps to human chomosome 2. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2, including Harlequin icthyosis, sitosterolemia and Alstr syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11751R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11751R-A350
Lokale Artikelnummer::
BOSSBS-11751R-A350
Beschreibung:
Polyglutamine(Q) tract binding protein-1 (PQBP-1) is a transcription repressor that associates with polyglutamine tract-containing transcription regulators and causative genes for neurodegenerative disorders. Hepta- and di-amino acid repeat sequences rich in polar residues are essential for PQBP-1 to interact with polyglutamine tract-containing proteins (i.e. huntingtin, androgen receptor and Brain-2). PQBP-1 contains a WWP/WW domain that binds proline-rich motifs and a C2 domain that can influence Ca2+-dependent phospholipid signaling. PQBP-1 localizes to the nucleus and is present in neurons throughout the brain, with abundant levels in hippocampus, cerebellar cortex and olfactory bulb. The human PQBP-1 gene maps to chromosome Xp11.23.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8383R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8383R-A488
Lokale Artikelnummer::
BOSSBS-8383R-A488
Beschreibung:
Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (UBE1s), ubiquitin-conjugating enzymes (UBE2s), and ubiquitin-protein ligases (UBE3s). When ubiquitin is activated by a UBE1, it is transferred to the cysteine residue on a UBE2. UBE2 then binds a UBE3, which transfers the ubiquitin from the UBE2 cysteine to a lysine residue on the target protein. Ubiquitin-conjugating enzyme E2 Q1 (UBE2Q1), also known as ubiquitin-protein ligase Q1 or ubiquitin carrier protein Q1, is an 422 amino acid protein belonging to the ubiquitin-conjugating enzyme (UBE2) family. Two named isoforms of UBE2Q1 exist as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12345R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12345R-A488
Lokale Artikelnummer::
BOSSBS-12345R-A488
Beschreibung:
HEM1 is a 1,127 amino acid single-pass membrane protein that localizes to the cytoplasmic side of the cell membrane. One of several members of the highly conserved HEM family of tissue-specific transmembrane proteins, HEM1 is expressed in cells of hematopoietic origin where it is thought to play an important role in oogenesis. The gene encoding HEM1 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11581R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11581R-A750
Lokale Artikelnummer::
BOSSBS-11581R-A750
Beschreibung:
PDZ-GEF1 is a 1499 amino acid cell membrane protein that functions as a guanine nucleotide exchange factor for Rap 1A, Rap 1B and Rap 2B GTPases. Expressed at highest levels in brain, PDZ-GEF1 is found at low levels in placenta, heart, lung and kidney, and undergoes post-translational phosphorylation following DNA damage. PDZ-GEF1 interacts with MAGI-2 and contains one Ras-GEF domain, a Ras-associating domain, one PDZ (DHR) domain, a single N-terminal Ras-GEF domain and a cyclic nucleotide-binding domain. The gene encoding PDZ-GEF1 maps to human chromosome 4q32.1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13588R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13588R-A350
Lokale Artikelnummer::
BOSSBS-13588R-A350
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 575 (ZNF575) is a 245 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZNF575 contains six C2H2-type zinc fingers through which it is thought to be involved in DNA-binding and transcriptional regulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8098R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8098R-FITC
Lokale Artikelnummer::
BOSSBS-8098R-FITC
Beschreibung:
The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC34 (coiled-coil domain containing 34), also known as Renal carcinoma antigen NY-REN-41, is a 373 amino acid protein that is expressed in testis, breast, lung, placenta, liver and small intestine. A translocation between the short arms of chromosomes 11 and 18 affecting the CCDC34 gene has been identified in a patient with hamartoma of the retinal pigment epithelium. There are two isoforms of CCDC34 that are produced as a result of alternative splicing events.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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