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3,6-Difluorphthalsäureanhydrid
Artikel-Nr:
(BOSSBS-11769R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11769R-HRP
Lokale Artikelnummer::
BOSSBS-11769R-HRP
Beschreibung:
The majority of mitochondrial-directed proteins are encoded by the nuclear genome and are transported to the mitochondria via regulated processes involving the mitochondrial Tom and Tim proteins (1). The mitochondrial Tim protein family is comprised of a large group of evolutionarily conserved proteins that are found in most eukaryotes (1,2). Import of nuclear-encoded precursor proteins into and across the mitochondrial inner membrane is mediated by two distinct complexes, the Tim23 complex and the Tim22 complex, which differ in their substrate specificity (1). Defects in Tim proteins are implicated in several neuro-degenerative diseases, suggesting important roles for Tim proteins in development and health (3,4). Tim8A and Tim8B, which map to human chromosomes Xq22.1 and 11q23.1-q23.2, respectively, are conserved proteins of the mitochondrial intermembrane space, which are organized in hetero-oligomeric complex with Tim13 (5,6,7). Tim8A is highly expressed in fetal and adult brain (5). Tim8A is mutated in deafness dystonia syndrome, a novel type of disease that causes severe neurological defects, thought to be caused by a defective mitochondrial protein transport system (5,8).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11512R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11512R-FITC
Lokale Artikelnummer::
BOSSBS-11512R-FITC
Beschreibung:
Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterized by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delay. Other associated clinical findings in BBS patients include diabetes, hypertension, and congenital heart defects. BBS genes map to multiple loci and encode fourteen proteins, BBS1-BBS14. Many BBS genes encode basal body or cilia proteins, suggesting that BBS is a ciliary dysfunction disorder. BBS10 (Bardet-Biedl syndrome 10), also known as chromosome 12 open reading fame 58, C12orf58 or FLJ23560, is a novel 723 amino acid protein belonging to the TCP-1 chaperonin family. BBS10 localizes to the basal body of primary cilium and assists in protein folding upon ATP hydrolysis. Inhibition of BBS10 has been found to impair ciliogenesis, activate the glycogen synthase kinase 3 pathway and cause peroxisome proliferator-activated receptor nuclear accumulation. The gene encoding BBS10 contains two exons and maps to human chromosome 12q21.2.
VE:
1 * 100 µl
Artikel-Nr:
(612-3234)
Lieferant:
SciLabware
Hersteller-Artikelnummer::
3151/12WC
Lokale Artikelnummer::
BIBB3151/12WC
Beschreibung:
PYREX®, Borosilikatglas, mit PE-Stopfen.
VE:
1 * 5 ST
Artikel-Nr:
(BOSSBS-11843R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11843R-A647
Lokale Artikelnummer::
BOSSBS-11843R-A647
Beschreibung:
Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13140R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13140R-A680
Lokale Artikelnummer::
BOSSBS-13140R-A680
Beschreibung:
Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromsomal instability (1,2). The FA Group C complementation group gene encodes the protein FANCC, which is located in both cytoplasmic and nuclear compartments. FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at the G1/S boundary and the highest levels in the M-phase. The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3). A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4,5). Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, which is a transcriptional repressor (6). In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7,8), which suggests that FANCC indirectly suppresses the activity of PKR. These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8). In addition, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9461R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9461R-A647
Lokale Artikelnummer::
BOSSBS-9461R-A647
Beschreibung:
The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate and establishing boundaries of gene expression. Notch signaling activates the Hairy/Enhancer of split (HES) genes, which encode basic helix-loop-helix (bHLH) transcriptional repressors that are critical for directing embryonic patterning and development. The Hairy-related transcription factors (HRTs) comprise a subclass of bHLH proteins that exhibit structural similarity with the HES proteins and include HRT1, HRT2 and HRT3. The HRT family (also designated Hesr, Hey, CHF and Gridlock) contain a bHLH domain, an Orange domain and a novel YRPW domain, which is absent in HRT3. The Hairy-related genes map to human chromosomes 8q21, 6q21 and 1p34.3 for HRT1, HRT2 and HRT3, respectively, and are downstream targets for Notch signaling. HRT1 is expressed in the somitic mesoderm, central nervous system, kidney, heart, nasal epithelium and limb buds in murine embryos as well as in adult tissues. It has altered expression in many breast, lung and kidney tumors. Like HRT1, HRT2 and HRT3 are also expressed in developing somites, heart and nervous system.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3626R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3626R-CY7
Lokale Artikelnummer::
BOSSBS-3626R-CY7
Beschreibung:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. There have been at least 12 different PKC isoforms identified in humans to date including alpha, beta I, beta II, gamma, delta, epsilon, zeta, eta, theta, iota, lambda, and mu. PKC gamma is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3730R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3730R-CY7
Lokale Artikelnummer::
BOSSBS-3730R-CY7
Beschreibung:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. There have been at least 12 different PKC isoforms identified in humans to date including alpha, beta I, beta II, gamma, delta, epsilon, zeta, eta, theta, iota, lambda, and mu. PKC gamma is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
VE:
1 * 100 µl
Lieferant:
Restek
Beschreibung:
Single-component explosives solutions supports US department of defense base closures and remediation.
Artikel-Nr:
(SCOI285203720)
Lieferant:
SI Analytics
Hersteller-Artikelnummer::
285203720
Lokale Artikelnummer::
SCOI285203720
Beschreibung:
Druckerpapierrolle für Drucker Z 890, Universalpapier, Breite 76 mm, Außendurchmesser 80 mm, innerer Kern 12 mm, Für: SI Analytics ProLab 2000/4000/3000
VE:
1 * 1 ST
Artikel-Nr:
(CALB4610-100ML)
Lieferant:
Merck Millipore (Calbiochem)
Hersteller-Artikelnummer::
4610-100ML
Lokale Artikelnummer::
CALB4610-100ML
Beschreibung:
Formamid, OmniPur®, deionisiert, Millipore®
VE:
1 * 100 mL
Artikel-Nr:
(SIAL694959-25G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
694959-25G
Lokale Artikelnummer::
SIAL694959-25G
Beschreibung:
Anthracen, Sigma-Aldrich®
VE:
1 * 25 g
Artikel-Nr:
(BOCH5010)
Lieferant:
BOCHEM
Hersteller-Artikelnummer::
5010
Lokale Artikelnummer::
BOCH5010
Beschreibung:
Foot for rods, made from stainless steel 18/10. With anti-slip rubber protection.
VE:
1 * 1 ST
Artikel-Nr:
(AGLSM5330AA-001)
Lieferant:
AGILENT
Hersteller-Artikelnummer::
M5330AA-001
Lokale Artikelnummer::
AGLSM5330AA-001
Beschreibung:
Kapillarelektrophorese-System mit gepulstem Feld für die Qualitätskontrolle von DNA- und RNA-Proben mit hohem Molekulargewicht.
VE:
1 * 1 ST
Lieferant:
BROTHER
Beschreibung:
Brother non-laminated tape with standard adhesive is great to use indoors for hobbies, organising, or crafts.
Artikel-Nr:
(733-2133)
Lieferant:
Corning
Hersteller-Artikelnummer::
IMAG-12T
Lokale Artikelnummer::
AXYGIMAG-12T
Beschreibung:
The magnetic separation devices (MSD) are essential in any paramagnetic bead-based purification process. These IMAG™ devices are designed for a manual process.
VE:
1 * 1 ST
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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