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4-Oxohexahydrocyclopenta[c]pyrrole-2-carboxylic+acid+tert-butyl+e
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4-Oxohexahydrocyclopenta[c]pyrrole-2-carboxylic+acid+tert-butyl+e
Artikel-Nr:
(BOSSBS-11457R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11457R-A647
Lokale Artikelnummer::
BOSSBS-11457R-A647
Beschreibung:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11457R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11457R-A350
Lokale Artikelnummer::
BOSSBS-11457R-A350
Beschreibung:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
VE:
1 * 100 µl
Artikel-Nr:
(280233V)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC280233V
Beschreibung:
EDTA Eisen(III)mononatriumsalz
VE:
1 * 250 g
Lieferant:
Metro International
Beschreibung:
The open wire design of these heavy-gauge shelves minimizes dust accumulation and allows a free circulation of air, greater visibility of stored items and greater light penetration. Metroseal 3 with microban provides corrosion resistant finish for wet or high humidity environments with a 12 year warranty against rust and corrosion. Microban antimicrobial is built into the finish to keep the product 'cleaner between cleanings'.
Artikel-Nr:
(BOSSBS-2603R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2603R-A750
Lokale Artikelnummer::
BOSSBS-2603R-A750
Beschreibung:
Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1288G-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1288G-A350
Lokale Artikelnummer::
BOSSBS-1288G-A350
Beschreibung:
Myostatin (GDF8)is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor beta superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1288G-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1288G-CY7
Lokale Artikelnummer::
BOSSBS-1288G-CY7
Beschreibung:
Myostatin (GDF8)is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor beta superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8270R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8270R-CY3
Lokale Artikelnummer::
BOSSBS-8270R-CY3
Beschreibung:
Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.Tissue specificity:Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1288G-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1288G-CY3
Lokale Artikelnummer::
BOSSBS-1288G-CY3
Beschreibung:
Myostatin (GDF8)is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor beta superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8270R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8270R-A750
Lokale Artikelnummer::
BOSSBS-8270R-A750
Beschreibung:
Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.Tissue specificity:Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1288G-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1288G-A488
Lokale Artikelnummer::
BOSSBS-1288G-A488
Beschreibung:
Myostatin (GDF8)is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor beta superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8573R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8573R-A750
Lokale Artikelnummer::
BOSSBS-8573R-A750
Beschreibung:
Displays NADPH-dependent dicarbonyl reductase activity <i>in vitro</i> with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed <i>in vitro</i> with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilisation and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8573R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8573R-A680
Lokale Artikelnummer::
BOSSBS-8573R-A680
Beschreibung:
Displays NADPH-dependent dicarbonyl reductase activity <i>in vitro</i> with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed <i>in vitro</i> with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilisation and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
VE:
1 * 100 µl
Lieferant:
FLUOROCHEM
Beschreibung:
1,2-Dibromtetrafluorbenzol
Artikel-Nr:
(BOSSBS-6318R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6318R-A488
Lokale Artikelnummer::
BOSSBS-6318R-A488
Beschreibung:
Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.Involvement in disease: Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPDA) ; also known as Niemann-Pick disease classical infantile form. It is an early-onset lysosomal storage disorder caused by failure to hydrolyze sphingomyelin to ceramide. It results in the accumulation of sphingomyelin and other metabolically related lipids in reticuloendothelial and other cell types throughout the body, leading to cell death. Niemann-Pick disease type A is a primarily neurodegenerative disorder characterized by onset within the first year of life, mental retardation, digestive disorders, failure to thrive, major hepatosplenomegaly, and severe neurologic symptoms. The severe neurological disorders and pulmonary infections lead to an early death, often around the age of four. Clinical features are variable. A phenotypic continuum exists between type A (basic neurovisceral) and type B (purely visceral) forms of Niemann-Pick disease, and the intermediate types encompass a cluster of variants combining clinical features of both types A and B.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6318R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6318R-FITC
Lokale Artikelnummer::
BOSSBS-6318R-FITC
Beschreibung:
Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.Involvement in disease: Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPDA) ; also known as Niemann-Pick disease classical infantile form. It is an early-onset lysosomal storage disorder caused by failure to hydrolyze sphingomyelin to ceramide. It results in the accumulation of sphingomyelin and other metabolically related lipids in reticuloendothelial and other cell types throughout the body, leading to cell death. Niemann-Pick disease type A is a primarily neurodegenerative disorder characterized by onset within the first year of life, mental retardation, digestive disorders, failure to thrive, major hepatosplenomegaly, and severe neurologic symptoms. The severe neurological disorders and pulmonary infections lead to an early death, often around the age of four. Clinical features are variable. A phenotypic continuum exists between type A (basic neurovisceral) and type B (purely visceral) forms of Niemann-Pick disease, and the intermediate types encompass a cluster of variants combining clinical features of both types A and B.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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