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5,7-Diphenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
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5,7-Diphenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
Artikel-Nr:
(BOSSBS-5866R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5866R-A555
Lokale Artikelnummer::
BOSSBS-5866R-A555
Beschreibung:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1876R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1876R-A680
Lokale Artikelnummer::
BOSSBS-1876R-A680
Beschreibung:
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3960R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3960R
Lokale Artikelnummer::
BOSSBS-3960R
Beschreibung:
The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7504R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7504R-A750
Lokale Artikelnummer::
BOSSBS-7504R-A750
Beschreibung:
Laminin S binds to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin S is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta 2 is a subunit of laminin 3 (Laminin S), laminin 4 (S merosin), and laminin 7 (KS laminin).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0651R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0651R-A647
Lokale Artikelnummer::
BOSSBS-0651R-A647
Beschreibung:
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15409R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15409R-A350
Lokale Artikelnummer::
BOSSBS-15409R-A350
Beschreibung:
CYP51A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyse many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalysing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7504R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7504R-CY3
Lokale Artikelnummer::
BOSSBS-7504R-CY3
Beschreibung:
Laminin S binds to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin S is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta 2 is a subunit of laminin 3 (Laminin S), laminin 4 (S merosin), and laminin 7 (KS laminin).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0400R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0400R-A750
Lokale Artikelnummer::
BOSSBS-0400R-A750
Beschreibung:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8034R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8034R-A350
Lokale Artikelnummer::
BOSSBS-8034R-A350
Beschreibung:
Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.Tissue specificity:Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8034R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8034R-A680
Lokale Artikelnummer::
BOSSBS-8034R-A680
Beschreibung:
Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerisation. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.Tissue specificity:Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8034R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8034R-A555
Lokale Artikelnummer::
BOSSBS-8034R-A555
Beschreibung:
Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.Tissue specificity:Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11710R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11710R-CY7
Lokale Artikelnummer::
BOSSBS-11710R-CY7
Beschreibung:
The protein encoded by this gene is one of several proteins that interact with NEDD4, a member of a family of ubiquitin-protein ligases. These proteins have PY motifs in common that bind to the WW domains of NEDD4. NEDD4 is developmentally regulated, and is highly expressed in embryonic tissues. Mutations in this gene (i.e., intronic insertions of >100 copies of pentanucleotide repeats including a (TGGAA)n sequence) are associated with spinocerebellar ataxia type 31. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0628R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0628R-HRP
Lokale Artikelnummer::
BOSSBS-0628R-HRP
Beschreibung:
ZNF300 contains C2H2 (or Kruppel)-type zinc finger motifs that tetrahedrally coordinate zinc ions and form a protein structure that can bind DNA and regulate transcription (Gou et al.,2004 [PubMed 14746915]). ZNF300 belongs to the krueppel C2H2 type zinc finger protein family. It contains twelve C2H2 type zinc fingers and one KRAB domain. ZNF300 has a transcriptional repressor activity. Expressed mostly in heart, skeletal muscle and brain. Isoforms 1 and 2 are highly expressed in testis. There are three named isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12343R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12343R-A350
Lokale Artikelnummer::
BOSSBS-12343R-A350
Beschreibung:
TRB-1 is a 372 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase superfamily. Expressed ubiquitously with highest expression in bone marrow, thyroid gland, skeletal muscle and pancreas, TRB-1 interacts with MAPK kinases and is thought to regulate the activation of MAP kinses, possibly controlling MAP kinase cascades. The gene encoding TRB-1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1876R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1876R-CY3
Lokale Artikelnummer::
BOSSBS-1876R-CY3
Beschreibung:
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8345R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8345R-A647
Lokale Artikelnummer::
BOSSBS-8345R-A647
Beschreibung:
FOP, is a 399 amino acid protein that localizes to the centrosome and contains one LisH domain. Expressed ubiquitously with highest expression in kidney, heart, muscle, colon, liver, testis and pancreas, FOP functions as a homodimer that interacts with EB1 and CEP350 and is essential for anchoring microtubules to centrosomes. Chromosomal aberrations that involve the FOP gene are associated with the pathogenesis of stem cell myeloproliferative disorder (MPD), a condition that is characterized by eosinophilia and myeloid hyperplasia and ultimately leads to acute myeloid leukemia. FOP is expressed as multiple isoforms that are produced by alternative splicing events.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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