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(S)-1-(5-Fluoropyrimidin-2-yl)ethanamine+hydrochloride
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(S)-1-(5-Fluoropyrimidin-2-yl)ethanamine+hydrochloride
Lieferant:
HORIBA
Beschreibung:
These waterproof pocket meters directly measure calcium, potassium or sodium concentrations in 0,3 ml sample (or 0,05 ml sample with sampling sheet B). The unique flat sensor allows measurement of viscous liquids, solids, and even powder samples. The sensor does not need to be dipped into the sample, a few drops are sufficient.
Artikel-Nr:
(PRSI29-568)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-568
Lokale Artikelnummer::
PRSI29-568
Beschreibung:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IV is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and of proximal renal tubules. Its exact function is not known, however, it may have a role in inherited renal abnormalities of bicarbonate transport.Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IV is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and of proximal renal tubules. Its exact function is not known, however, it may have a role in inherited renal abnormalities of bicarbonate transport.
VE:
1 * 100 µG
Artikel-Nr:
(SIAL244988-2G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
244988-2G
Lokale Artikelnummer::
SIAL244988-2G
Beschreibung:
Bis(1,5-cyclooctadien)nickel(0), Sigma-Aldrich®
VE:
1 * 2 g
Artikel-Nr:
(HONE12038.9025)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
12038.9025
Lokale Artikelnummer::
HONE12038.9025
Beschreibung:
Calciumhydroxid 95-100,5% (durch komplexometrische Analyse), puriss. FCC, Ph. Eur., USP, reinst, Fluka™
VE:
1 * 25 kg
Lieferant:
Sigma-Aldrich
Beschreibung:
Palladium 10% auf Aktivkohle mit 50 % Wasser benetzt Hydrierkatalysator Degussa Type E101 NE/W, Sigma-Aldrich®
Artikel-Nr:
(PRSI90-138)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-138
Lokale Artikelnummer::
PRSI90-138
Beschreibung:
Calreticulin is involved in regulation of intracellular Ca²⁺ homoeostasis and ER Ca²⁺ capacity. It constitutes together with calnexin and ERp57 the ‘calreticulin/calnexin cycle’ that is responsible for folding and quality control of newly synthesised glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumour cells, increasing phagocytosis.
VE:
1 * 50 µG
Artikel-Nr:
(HACH2064100)
Lieferant:
Hach
Hersteller-Artikelnummer::
2064100
Lokale Artikelnummer::
HACH2064100
Beschreibung:
Digital titration provides a more precise and accurate method than the drop test method.
VE:
1 * 1 KIT
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 7783-13-3
Artikel-Nr:
(PRSI79-652)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-652
Lokale Artikelnummer::
PRSI79-652
Beschreibung:
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-1687R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1687R-A750
Lokale Artikelnummer::
BOSSBS-1687R-A750
Beschreibung:
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterised by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localisation, and cellular function. Phosphorylates TPM1, enhancing stress fibre formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-133 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition. Isoform 2 cannot induce apoptosis but can induce membrane blebbing.
VE:
1 * 100 µl
Artikel-Nr:
(KRAF03632.2000)
Lieferant:
Bernd Kraft
Hersteller-Artikelnummer::
03632.2000
Lokale Artikelnummer::
KRAF03632.2000
Beschreibung:
Calcium Standard, 1000 mg/L, Calcium, Matrix: 0,5 M HNO₃, Anwendung: AAS-Standards
VE:
1 * 500 mL
Artikel-Nr:
(BOSSBS-1687R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1687R-HRP
Lokale Artikelnummer::
BOSSBS-1687R-HRP
Beschreibung:
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-133 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition. Isoform 2 cannot induce apoptosis but can induce membrane blebbing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3162R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3162R-A647
Lokale Artikelnummer::
BOSSBS-3162R-A647
Beschreibung:
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0231R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0231R-CY3
Lokale Artikelnummer::
BOSSBS-0231R-CY3
Beschreibung:
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3162R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3162R-A488
Lokale Artikelnummer::
BOSSBS-3162R-A488
Beschreibung:
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation.
VE:
1 * 100 µl
Lieferant:
TOSOH Bioscience
Beschreibung:
SkillPak 1 and 5 ml columns are designed for fast method development, resin screening or sample concentration. Pre-packed with TOYOPEARL®, TSKgel® or Ca++Pure-HA™ process chromatography media, these columns offer superior separation of biomelocules, such as monoclonal antibodies, proteins and oligonucleotides. SkillPak 50 and 200 ml pre-packed columns are the best solution for seamless scale up of methods developed on SkillPak 1 and 5.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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