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tert-Butyl+cyclopropanecarboxylate
Artikel-Nr:
(BOSSBS-3815R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3815R-FITC
Lokale Artikelnummer::
BOSSBS-3815R-FITC
Beschreibung:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3815R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3815R-A555
Lokale Artikelnummer::
BOSSBS-3815R-A555
Beschreibung:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9166R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9166R-A488
Lokale Artikelnummer::
BOSSBS-9166R-A488
Beschreibung:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc binding domains, a RING, a B box type 1 and a B box type 2, and a coiled coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternative splicing of this gene generates three transcript variants, named alpha, beta and gamma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12419R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12419R
Lokale Artikelnummer::
BOSSBS-12419R
Beschreibung:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.This antibody is reactive with 14-3-3 Alpha/Beta/Gamma/Delta/Epsilon.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11991R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11991R-CY3
Lokale Artikelnummer::
BOSSBS-11991R-CY3
Beschreibung:
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2A Alpha and PP2A Beta. The PP2A catalytic subunit associates with a variety of regulatory subunits. Regulatory subunits include PP2A-A-Alpha and -A-Beta, PP2A-B-Alpha and -B-Beta, PP2A-C-Alpha and -C-Beta, PP2A-B56-Alpha, -B56-Beta, -B56-gamma and -B56-Delta.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9166R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9166R-A555
Lokale Artikelnummer::
BOSSBS-9166R-A555
Beschreibung:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc binding domains, a RING, a B box type 1 and a B box type 2, and a coiled coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternative splicing of this gene generates three transcript variants, named alpha, beta and gamma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9166R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9166R-A350
Lokale Artikelnummer::
BOSSBS-9166R-A350
Beschreibung:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc binding domains, a RING, a B box type 1 and a B box type 2, and a coiled coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternative splicing of this gene generates three transcript variants, named alpha, beta and gamma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11160R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11160R-A647
Lokale Artikelnummer::
BOSSBS-11160R-A647
Beschreibung:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHGC4 (protocadherin gamma subfamily C, 4) is a 938 amino acid single-pass type I membrane protein that localizes to the cell membrane and contains six cadherin domains. Expressed as two alternatively spliced isoforms, PCDHGC4 functions as a potential calcium-dependent cell adhesion protein that is thought to be involved in the establishment and maintenance of neuronal connections within the brain. The gene encoding PCDHGC4 maps to a protocadherin gamma gene cluster which is localized to chromosome 5 and contains over 22 protocadherin genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11640R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11640R-CY3
Lokale Artikelnummer::
BOSSBS-11640R-CY3
Beschreibung:
Anterior pharynx defective 1 (Aph-1) is a polytopic, seven-pass membrane protein that functions as one of the four essential components in the presenilin-Gamma-secretase enzyme complex. This enzyme complex is necessary for the intra-membrane proteolysis of several different membrane proteins, including the beta-Amyloid precursor protein, and is involved in multiple neurodevelopmental signaling pathways. Aph-1b and Aph-1a are splice variants of Aph-1. Aph-1b specifically lacks exon 4, which encodes for the entire fourth transmembrane domain, causing the protein to be destabilized. Deficiency of Aph-1a causes a reduction in Gamma-secretase activity, however deficiency of Aph-1b does not; thus, Aph-1b may execute redundant functions in the cell. Aph-1b expression and Gamma-secretase activity may be implicated in neurodevelopmental disorders, such as schizophrenia.
VE:
1 * 100 µl
Artikel-Nr:
(BSENGP-030-50)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
GP-030-50
Lokale Artikelnummer::
BSENGP-030-50
Beschreibung:
Proopiomelanocortin (POMC) is the precursor of the melanocortin peptides alpha, beta and gamma. POMC neurons in the arcuate nucleus of the hypothalamus function as key central regulators of food intake and homeostatic control of energy balance in both rodents and non-human primates. MSH increases the pigmentation of skin by increasing the melanin production in melanocytes. MSH is produced in the pituitary gland and belongs to the POMC family.
VE:
1 * 50 µl
Lieferant:
Tonbo Biosciences
Beschreibung:
The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.
Artikel-Nr:
(70-5898-U100)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
70-5898-U100
Lokale Artikelnummer::
TNBO70-5898-U100
Beschreibung:
The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-3737R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3737R-A750
Lokale Artikelnummer::
BOSSBS-3737R-A750
Beschreibung:
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
This antibody recognizes actin of skeletal, cardiac, and smooth muscle cells. It is not reactive with other mesenchymal cells except for myoepithelium. Actin can be resolved on the basis of its isoelectric points into three distinctive components: alpha, beta, and gamma in order of increasing isoelectric point. Anti-muscle specific actin recognizes alpha and gamma isotypes of all muscle groups. Non-muscle cells such as vascular endothelial cells and connective tissues are non-reactive. Also, neoplastic cells of non-muscle-derived tissue such as carcinomas, melanomas, and lymphomas are negative.It stains tumors of smooth muscle (leiomyomas and leiomyosarcomas) as well as skeletal muscle (rhabdomyomas and rhabdomyosarcomas).
Lieferant:
Biotium
Beschreibung:
This antibody recognizes actin of skeletal, cardiac, and smooth muscle cells. It is not reactive with other mesenchymal cells except for myoepithelium. Actin can be resolved on the basis of its isoelectric points into three distinctive components: alpha, beta, and gamma in order of increasing isoelectric point. Anti-muscle specific actin recognizes alpha and gamma isotypes of all muscle groups. Non-muscle cells such as vascular endothelial cells and connective tissues are non-reactive. Also, neoplastic cells of non-muscle-derived tissue such as carcinomas, melanomas, and lymphomas are negative.It stains tumors of smooth muscle (leiomyomas and leiomyosarcomas) as well as skeletal muscle (rhabdomyomas and rhabdomyosarcomas).
Lieferant:
Biotium
Beschreibung:
This antibody recognizes actin of skeletal, cardiac, and smooth muscle cells. It is not reactive with other mesenchymal cells except for myoepithelium. Actin can be resolved on the basis of its isoelectric points into three distinctive components: alpha, beta, and gamma in order of increasing isoelectric point. Anti-muscle specific actin recognizes alpha and gamma isotypes of all muscle groups. Non-muscle cells such as vascular endothelial cells and connective tissues are non-reactive. Also, neoplastic cells of non-muscle-derived tissue such as carcinomas, melanomas, and lymphomas are negative.It stains tumors of smooth muscle (leiomyomas and leiomyosarcomas) as well as skeletal muscle (rhabdomyomas and rhabdomyosarcomas).
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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