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3,5-Dioxocyclohexanecarboxylic+acid
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3,5-Dioxocyclohexanecarboxylic+acid
Artikel-Nr:
(BOSSBS-0598R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0598R-A750
Lokale Artikelnummer::
BOSSBS-0598R-A750
Beschreibung:
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6369R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6369R-A555
Lokale Artikelnummer::
BOSSBS-6369R-A555
Beschreibung:
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2891R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2891R-A647
Lokale Artikelnummer::
BOSSBS-2891R-A647
Beschreibung:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5501R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5501R-A647
Lokale Artikelnummer::
BOSSBS-5501R-A647
Beschreibung:
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7846R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7846R-A750
Lokale Artikelnummer::
BOSSBS-7846R-A750
Beschreibung:
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerisation-coupled manner. In the complex, it mediates the interaction with microtubules.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5773R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5773R-A488
Lokale Artikelnummer::
BOSSBS-5773R-A488
Beschreibung:
FGF22 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development.Fibroblast Growth Factor-22 stimulates the proliferation and activation of cells that express FGF receptor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2747R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2747R-A555
Lokale Artikelnummer::
BOSSBS-2747R-A555
Beschreibung:
The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9603R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9603R-A647
Lokale Artikelnummer::
BOSSBS-9603R-A647
Beschreibung:
TEF-3, is a 427 amino acid member of the transcriptional enhancer factor (TEF) family of proteins that are characterized by the presence of a TEA DNA-binding domain. Localized to the nucleus and expressed primarily in skeletal muscle, TEF-3 functions as a transcriptional regulator by binding specifically and non-cooperatively to the M-CAT motif found in the promotors of muscle-specific genes, thereby directing their subsequent expression. TEF-3 contains one TEA DNA-binding domain and is expressed as multiple isoforms due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6863R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6863R-A488
Lokale Artikelnummer::
BOSSBS-6863R-A488
Beschreibung:
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2931R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2931R-A680
Lokale Artikelnummer::
BOSSBS-2931R-A680
Beschreibung:
Mammaglobin is a gene that is expressed almost exclusively in the normal breast epithelium and human breast cancer. It is a member of the secretoglobin gene family and forms a heterodimer with lipophilin B. It has been suggested that mammaglobin may be a useful marker for breast cancer clinical research. Studies investigating the detection of mRNA by RT PCR from circulating carcinoma cells in the peripheral blood of breast cancer patients have shown that mammaglobin is a highly specific marker and correlates with several prognostic factors, such as lymph node involvement.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1035R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1035R-A680
Lokale Artikelnummer::
BOSSBS-1035R-A680
Beschreibung:
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12493R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12493R-A488
Lokale Artikelnummer::
BOSSBS-12493R-A488
Beschreibung:
APOBEC2 is a 224 amino acid protein that belongs to the cytidine and deoxycytidylate deaminase family. Expressed exclusively in heart and skeletal muscle, APOBEC2 is thought to be a probable C (cytidine) to U (uridine) editing enzyme. However, unlike other members of the family, such as APOBEC1, which mediates the editing of apolipoprotein (apo) B mRNA, APOBEC2 does not display any detectable apoB mRNA editing activity. Also, APOBEC2 has been shown to have low, but definite, intrinsic cytidine deaminase activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8422R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8422R-A488
Lokale Artikelnummer::
BOSSBS-8422R-A488
Beschreibung:
This gene is located within a region of a segmental duplication on chromosome 16p. The product of this gene belongs to the eukaryotic subfamily of the BolA-like proteins. This gene encodes the BolA-like protein 2. The BolA-like proteins are widely conserved from prokaryotes to eukaryotes, and these proteins seem to be involved in cell proliferation or cell-cycle regulation. This duplicated region contains a complete copy of the short splice variant of the BOLA2 gene and a partial copy of the long splice variant of the BOLA2 gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6234R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6234R-A680
Lokale Artikelnummer::
BOSSBS-6234R-A680
Beschreibung:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl functionDOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function. There are 4 isoforms generated by alternative splicing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5077R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5077R-A350
Lokale Artikelnummer::
BOSSBS-5077R-A350
Beschreibung:
LASS2 (LAG1 homolog, ceramide synthase 2) has sequence similarity to yeast longevity assurance gene 1. It is thought to be involved in sphingolipid synthesis. Expression of LASS2 is transiently increased during the period of active myelination and is specifically localized to white matter tracts of the brain, including the Schwann cells of sciatic nerves suggesting that LASS2 is important for the synthesis of dihydroceramide used for synthesis of myelin sphingolipids. Expression of LASS2 in hepatocellular carcinoma cell lines suppresses the growth of cancer cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4539R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4539R-A488
Lokale Artikelnummer::
BOSSBS-4539R-A488
Beschreibung:
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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