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4-Chloro-1H-pyrazolo[4,3-c]pyridine
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4-Chloro-1H-pyrazolo[4,3-c]pyridine
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 35231-44-8
Lieferant:
Biotium
Beschreibung:
Recognizes a glycoprotein of ~200 kDa, identified as carbonic anhydrase IX (CAIX/gp200). Carbonic Anhydrases (CAs) are members of a large family of zinc metallo-enzymes that catalyze the reversible hydration of carbon dioxide. CAs are involved in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric juice. They show extensive diversity in distribution and in their subcellular localization. CA IX is specifically expressed in clear-cell renal carcinomas.
Artikel-Nr:
(BOSSBS-12574R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12574R-A750
Lokale Artikelnummer::
BOSSBS-12574R-A750
Beschreibung:
p130 represents one of several known substrates for v-Crk encoded p47. p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell Signalling. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing Signalling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 5617-74-3
Artikel-Nr:
(ACRO265650010)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
265650010
Lokale Artikelnummer::
ACRO265650010
Beschreibung:
CAS No.: 28250-14-8
VE:
1 * 1 g
Artikel-Nr:
(BOSSBS-11830R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11830R-A647
Lokale Artikelnummer::
BOSSBS-11830R-A647
Beschreibung:
Carbonic anhydrases (CAs) are members of a large family of zinc metalloenzymes responsible for catalyzing the reversible hydration of carbon dioxide. CAs show extensive diversity in their distribution and subcellular localization. They are involved in a variety of biological processes, including calcification, bone resorption, respiration, acid-base balance and the formation of aqueous humor, saliva, gastric juice and cerebrospinal fluid. CA X also referred to as Carbonic anhydrase-related protein X (CA-RP X) or Cerebral protein 15, is a member of the carbonic anhydrase family that lacks two of the three Zn-binding motifs essential for carbonic anhydrase activity. For this reason, CA X does not exhibit catalytic activity. It is expressed primarily in brain and kidney and may play a role in brain development.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 53188-07-1
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 25015-63-8
Artikel-Nr:
(BOSSBS-11977R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11977R-CY5
Lokale Artikelnummer::
BOSSBS-11977R-CY5
Beschreibung:
NCS-1 (for neuronal calcium sensor-1, also designated frequenin) belongs to a highly conserved family of EF-hand-containing Ca++-binding proteins expressed mainly in neurons. NCS-1 is localized to neuronal cell bodies and axons throughout the brain and spinal cord. It is also expressed in glial cells and in neuroendocrine bovine adrenal chromaffin and PC12 cells. NCS-1 is a regulatory protein involved in Ca++-dependent exocytosis of synaptic vesicles and dense core granules. NCS-1 also functions in the voltage-independent autocrine pathway that negatively regulates non-L-type Ca++ channels.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1906R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1906R-FITC
Lokale Artikelnummer::
BOSSBS-1906R-FITC
Beschreibung:
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1906R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1906R-CY7
Lokale Artikelnummer::
BOSSBS-1906R-CY7
Beschreibung:
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1906R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1906R-CY5.5
Lokale Artikelnummer::
BOSSBS-1906R-CY5.5
Beschreibung:
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 14337-53-2
Artikel-Nr:
(ACRO108360250)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
108360250
Lokale Artikelnummer::
ACRO108360250
Beschreibung:
CAS No.: 1155-64-2
VE:
1 * 25 g
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 5466-77-3
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 15761-38-3
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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