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3-Aminopiperidine+hydrochloride,+N1-CBZ+protected
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3-Aminopiperidine+hydrochloride,+N1-CBZ+protected
Artikel-Nr:
(BOSSBS-11540R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11540R-CY7
Lokale Artikelnummer::
BOSSBS-11540R-CY7
Beschreibung:
The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I˚Bå and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system. CSN7 is phosphorylated by CK2 and is composed of two subunits; a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, as well as a coiled-coil region and is predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4976R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4976R-CY3
Lokale Artikelnummer::
BOSSBS-4976R-CY3
Beschreibung:
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
VE:
1 * 100 µl
Artikel-Nr:
(ENAMEN30003626.1G)
Lieferant:
SIA ENAMINE
Hersteller-Artikelnummer::
EN30003626.1G
Lokale Artikelnummer::
ENAMEN30003626.1G
Beschreibung:
2,4-Difluorphenylhydraziniumchlorid
VE:
1 * 1 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
Sigma-Aldrich
Beschreibung:
4-Brompyridiniumchlorid, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-2527R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2527R-FITC
Lokale Artikelnummer::
BOSSBS-2527R-FITC
Beschreibung:
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2527R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2527R-A555
Lokale Artikelnummer::
BOSSBS-2527R-A555
Beschreibung:
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
VE:
1 * 100 µl
Lieferant:
MP Biomedicals
Beschreibung:
Storage: Room Temperature
Guanidine hydrochloride consists of a network of guanidinium cations and chloride anions linked by N–H•••Cl hydrogen bonds, it is a strong chaotropic agent. Guanidine HCl may agglomerate upon storage. It may appear as a free-flowing crystalline powder, a free flowing powder with solid material dispersed throughout, or a solid. The quality of the product does not appear to be affected and solutions prepared from the free-flowing and lumpy guanidine HCl appear identical. Guanidine hydrochloride can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. Also used in the isolation of RNA. Guanidine hydrochloride is a strong chaotropic agent useful for the denaturation and subsequent refolding of protein, it can solubilize insoluble or denatured proteins such as inclusion bodies and be used for the recovery of periplasmic proteins.
Artikel-Nr:
(EHERC10428000)
Lieferant:
EHRENSTORFER
Hersteller-Artikelnummer::
C10428000
Lokale Artikelnummer::
EHERC10428000
Beschreibung:
Fuchsin basisch
VE:
1 * 0,1 g
Lieferant:
ELTEN
Beschreibung:
Metallfreie Clogs, Obermaterial aus glatter, reißfester Mikrofaser mit verstellbarem Velcro®-Fersenriemen und einer Mono-Density-PU-Sohle (2,5 mm, öl-, kraftstoff- und abriebbeständig, Hitzebeständigkeit bis zu ca. 130 °C).
Lieferant:
ELTEN
Beschreibung:
Leichte, antistatische Clogs, Obermaterial aus glatter, reißfester Mikrofaser mit verstell- und klappbarem Fersenriemen und einer Mono-Density-PU-Sohle (2,5 mm, öl-, kraftstoff- und abriebbeständig, Hitzebeständigkeit bis zu ca. 130 °C).
Artikel-Nr:
(BOSSBS-7112R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7112R-CY7
Lokale Artikelnummer::
BOSSBS-7112R-CY7
Beschreibung:
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13046R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13046R-CY3
Lokale Artikelnummer::
BOSSBS-13046R-CY3
Beschreibung:
Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings. EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, a process that is essential for terminating the postsynaptic action of glutamate. The re-uptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, which is caused by the accumulation of amino acid neurotransmitters. EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum. The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities. EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina. Although EAAT5 shares the structural homologies of the EAAT family, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering.
VE:
1 * 100 µl
Lieferant:
ANSELL HEALTH CARE
Beschreibung:
Diese Nylonhandschuhe mit dünner Nitrilbeschichtung bieten Schutz vor Chemikalien, Ölen und anderen reizenden Flüssigkeiten, wie z.B. Bioziden, Fungiziden, Lacken, Tinten und Farbstoffen.
Artikel-Nr:
(HONCR1224-10MG)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
R1224-10MG
Lokale Artikelnummer::
HONCR1224-10MG
Beschreibung:
High quality inorganic and organic reference materials produced according to ISO 9001.
VE:
1 * 10 mg
Artikel-Nr:
(ENAMEN30007656.1G)
Lieferant:
SIA ENAMINE
Hersteller-Artikelnummer::
EN30007656.1G
Lokale Artikelnummer::
ENAMEN30007656.1G
Beschreibung:
3,5-Dimethylphenylhydraziniumchlorid
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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