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3,6-Dithia-1,8-octandiol
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3,6-Dithia-1,8-octandiol
Artikel-Nr:
(BOSSBS-11296R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11296R-CY7
Lokale Artikelnummer::
BOSSBS-11296R-CY7
Beschreibung:
17Beta-HSD4 (17Beta-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-Beta Estradiol dehydrogenase type IV. It belongs to the 17Beta-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17Beta-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol Beta-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17Beta-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17Beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.
VE:
1 * 100 µl
Artikel-Nr:
(APOSBIM2043-25MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
BIM2043-25MG
Lokale Artikelnummer::
APOSBIM2043-25MG
Beschreibung:
4-Methylumbelliferyl β-D-galactopyranoside-6-sulphate sodium salt
VE:
1 * 25 mg
Artikel-Nr:
(USBIB0901-01C-100)
Lieferant:
US Biological
Hersteller-Artikelnummer::
B0901-01C-100
Lokale Artikelnummer::
USBIB0901-01C-100
Beschreibung:
Anti-DEFB4A Sheep polyclonal antibody unconjugated
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3548R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3548R-CY5
Lokale Artikelnummer::
BOSSBS-3548R-CY5
Beschreibung:
Dystrobrevin beta is a component of the dystrophin-associated protein complex and interacts with dystrophin short form DP71, syntrophins SNTG1 and SNTG2. It localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. 4 isoforms produced by alternative splicing have been identified.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3548R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3548R-CY7
Lokale Artikelnummer::
BOSSBS-3548R-CY7
Beschreibung:
Dystrobrevin beta is a component of the dystrophin-associated protein complex and interacts with dystrophin short form DP71, syntrophins SNTG1 and SNTG2. It localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. 4 isoforms produced by alternative splicing have been identified.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12854R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12854R-A680
Lokale Artikelnummer::
BOSSBS-12854R-A680
Beschreibung:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12856R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12856R-A680
Lokale Artikelnummer::
BOSSBS-12856R-A680
Beschreibung:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12873R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12873R-FITC
Lokale Artikelnummer::
BOSSBS-12873R-FITC
Beschreibung:
Bone morphogenic proteins (BMPs) are members of the TGF Beta superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGF Beta receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12873R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12873R-A680
Lokale Artikelnummer::
BOSSBS-12873R-A680
Beschreibung:
Bone morphogenic proteins (BMPs) are members of the TGF Beta superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGF Beta receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13268R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13268R-FITC
Lokale Artikelnummer::
BOSSBS-13268R-FITC
Beschreibung:
Galactose Mutarotase is a member of the aldose epimerase family and is involved in hexose metabolism. Through its catalytic activity, Galactose Mutarotase converts beta-aldose to alpha-aldose on several sugars, including D-glucose, L-arabinose and D-xylose. Found in the cytoplasm of most cells, Galactose Mutarotase plays a key role in galactose metabolism by catalyzing the conversion of beta-D-galactose to alpha-D-galactose. The enzyme contains two residues, Glu 304 and His 170, that are critical for catalysis, as well as His 96 and Asp 243, which are important for proper substrate recognition by the active site. No known diseases have been associated with mutations in the Galactose Mutarotase gene, although inhibition of Galactose Mutarotase activity could potentially be associated with a build-up of unmetabolized sugars during metabolism.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10425R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10425R-A647
Lokale Artikelnummer::
BOSSBS-10425R-A647
Beschreibung:
Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10425R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10425R
Lokale Artikelnummer::
BOSSBS-10425R
Beschreibung:
Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10425R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10425R-FITC
Lokale Artikelnummer::
BOSSBS-10425R-FITC
Beschreibung:
Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1152R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1152R-A488
Lokale Artikelnummer::
BOSSBS-1152R-A488
Beschreibung:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1152R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1152R-HRP
Lokale Artikelnummer::
BOSSBS-1152R-HRP
Beschreibung:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10425R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10425R-CY5
Lokale Artikelnummer::
BOSSBS-10425R-CY5
Beschreibung:
Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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