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3-Brom-2-fluor-5-methylphenylborons\u00E4ure
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3-Brom-2-fluor-5-methylphenylborons\u00E4ure
Artikel-Nr:
(BOSSBS-5661R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5661R-A555
Lokale Artikelnummer::
BOSSBS-5661R-A555
Beschreibung:
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6162R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6162R-A555
Lokale Artikelnummer::
BOSSBS-6162R-A555
Beschreibung:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for normal cytokinesis and cilia signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15483R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15483R-A750
Lokale Artikelnummer::
BOSSBS-15483R-A750
Beschreibung:
HIBADH is a 336 amino acid mitochondrial enzyme that catalyses the NAD+-dependent, reversible oxidisation of 3-Hydroxyisobutyrate to methylmalonate semialdehyde, an intermediate of valine catabolism. The enzyme functions as a homodimer between a pH of 7,0 and 10,0, with optimal activity between 8,8 and 9,0. It was previously hypothesised that defects in the gene encoding HIBADH may be the cause of 3-Hydroxyisobutyric aciduria, a rare disorder that is characterised by a variety of clinical manifestations such as neurodevelopmental problems and dysmorphic features. However, it was shown that HIBADH activity was equal in patients with 3-Hydroxyisobutyric aciduria as compared with controls.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5389R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5389R-A647
Lokale Artikelnummer::
BOSSBS-5389R-A647
Beschreibung:
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5357R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5357R-A350
Lokale Artikelnummer::
BOSSBS-5357R-A350
Beschreibung:
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11799R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11799R-A488
Lokale Artikelnummer::
BOSSBS-11799R-A488
Beschreibung:
TMEM18 is a 140 amino acid multi-pass membrane protein that localizes to the nuclear membrane and is expressed in the brain. TMEM18 functions as a cell migration modulator which enhances the glioma-specific migration ability of neural precursor and neural stem cells.Overexpression of TMEM18 increases migration of human and murine neural stem cells, whereas knockdown of TMEM18 mRNA reduces cellular migration. Two specific single nucleotide polymorphisms (SNPs) within the TMEM18 gene locus known as rs6548238 and rs756131 have been linked to obesity susceptibility.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3927R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3927R-A488
Lokale Artikelnummer::
BOSSBS-3927R-A488
Beschreibung:
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9441R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9441R-A647
Lokale Artikelnummer::
BOSSBS-9441R-A647
Beschreibung:
The downstream regulatory element, DRE, acts as a location-dependent gene silencer. DREAM (for DRE-antagonist modulator) is a Ca2+-regulated transcriptional repressor that specifically binds to the DRE. DREAM regulates transcription of prodynorphin and c-Fos genes and shows 99% nucleotide homology to the Kv channel-interacting proteins (KChIPs). KChIP family members include KChIP1, which is expressed in brain, KChIP2, which is expressed in heart, brain, and lung, KChIP3 (also designated calsenilin), which is expressed in brain and testis and KChIP4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7732R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7732R-A555
Lokale Artikelnummer::
BOSSBS-7732R-A555
Beschreibung:
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15401R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15401R-A680
Lokale Artikelnummer::
BOSSBS-15401R-A680
Beschreibung:
H2BFWT (H2B histone family member W testis-specific) is a 175 amino acid nuclear membrane histone that belongs to the histone H2B family. In contrast to most H2B histones, H2BFWT does not contain the conserved C-terminal residue involved in monoubiquitination, but is structurally indistinguishable from conventional H2B histones. Also varying from other H2B histones, H2BFWT does not participate in the recruitment of chromosome condensation factors or in the assembly of mitotic chromsomes. Expressed in testis, H2BFWT is present in sperm cells and may be essential to telomere function.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13323R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13323R-A680
Lokale Artikelnummer::
BOSSBS-13323R-A680
Beschreibung:
GCSH is a 173 amino acid mitochondrial protein that contains one lipoyl-binding domain and belongs to the gcvH family. Defects in the gene encoding GCSH are the cause of glycine encephalopathy (GCE), an autosomal recessive disease that is also referred to as non-ketotic hyperglycinemia (NKH). Characterized by severe neurological symptoms, patients with GCE have a large amount of glycine accumulated in their body fluids. The gene encoding GCSH maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11716R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11716R-A555
Lokale Artikelnummer::
BOSSBS-11716R-A555
Beschreibung:
CRBN is a 442 amino acid protein which is highly concentrated in human brain tissue. CRBN functions are thought to be related to energy metabolism, learning and memory. Localized to the cytoplasm, CRBN acts as a protease in mitochondria and is thought to regulate the assembly of KCNT1, as well as the surface expression of KCNT1 in brain regions known to affect memory and learning, such as the hippocampus. The gene encoding CRBN belongs to a family of ATP-dependent lon proteases that play a role in membrane trafficking and proteolysis. Defects in the CRBN gene are associated with mild mental retardation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3990R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3990R-A647
Lokale Artikelnummer::
BOSSBS-3990R-A647
Beschreibung:
This gene encodes a member of the glycogenin family. Glycogenin is a glycosyltransferase that catalyzes the formation of a short glucose polymer from uridine diphosphate glucose in an autoglucosylation reaction. This reaction is followed by elongation and branching of the polymer, catalyzed by glycogen synthase and branching enzyme, to form glycogen. This gene is expressed in muscle and other tissues. Mutations in this gene result in glycogen storage disease XV. This gene has pseudogenes on chromosomes 1, 8 and 13 respectively. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4081R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4081R-A488
Lokale Artikelnummer::
BOSSBS-4081R-A488
Beschreibung:
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3680R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3680R-A647
Lokale Artikelnummer::
BOSSBS-3680R-A647
Beschreibung:
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12040R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12040R-A488
Lokale Artikelnummer::
BOSSBS-12040R-A488
Beschreibung:
alpha2C-adrenergic receptors (alpha2C-AR) regulate neurotransmitter release from sympathetic nerves in the heart, and from adrenergic neurons in the central nervous system. alpha2C-AR can influence Parkinson’s disease, panic disorders, and Huntington disease (HD) progression. A genetic variant in the alpha2C-AR coding region (Del322-325) renders the receptor partially uncoupled from Gi, and is a contributing risk factor for heart failure. alpha2C-AR transcripts are present in rat muscle, heart, pancreas, and kidney.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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