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3-Brom-2-fluor-5-methylphenylborons\u00E4ure
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3-Brom-2-fluor-5-methylphenylborons\u00E4ure
Artikel-Nr:
(BOSSBS-13181R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13181R-A555
Lokale Artikelnummer::
BOSSBS-13181R-A555
Beschreibung:
This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7523R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7523R-A488
Lokale Artikelnummer::
BOSSBS-7523R-A488
Beschreibung:
Cellular localization: Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane. Membrane >caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4081R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4081R-A647
Lokale Artikelnummer::
BOSSBS-4081R-A647
Beschreibung:
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0115R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0115R-A750
Lokale Artikelnummer::
BOSSBS-0115R-A750
Beschreibung:
AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalisation. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0014R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0014R-A555
Lokale Artikelnummer::
BOSSBS-0014R-A555
Beschreibung:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11272R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11272R-A488
Lokale Artikelnummer::
BOSSBS-11272R-A488
Beschreibung:
Wolfram syndrome protein (WFS1) is an 890 amino acid protein that contains a cytoplasmic N-terminal domain, followed by nine-transmembrane domains and a luminal C-terminal domain. WFS1 is predominantly localized to the endoplasmic reticulum (ER) (1) and its expression is induced in response to ER stress, partially through transcriptional activation (2,3). Research studies have shown that mutations in the WFS1 gene lead to Wolfram syndrome, an autosomal recessive neurodegenerative disorder defined by young-onset, non-immune, insulin-dependent diabetes mellitus and progressive optic atrophy (4).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6866R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6866R-A647
Lokale Artikelnummer::
BOSSBS-6866R-A647
Beschreibung:
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15409R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15409R-A488
Lokale Artikelnummer::
BOSSBS-15409R-A488
Beschreibung:
CYP51A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyse many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalysing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3428R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3428R-A350
Lokale Artikelnummer::
BOSSBS-3428R-A350
Beschreibung:
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9719R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9719R-A680
Lokale Artikelnummer::
BOSSBS-9719R-A680
Beschreibung:
The PDE4A8 is a testis germ cell-specific PDE4A variant. There are two PDE4A variants identified in rat testis (PDE4A8 and an un-characterised 76 kDa PDE4A protein). Spermatogenesis is accompanied by expression of a varied repertoire of PDE4 enzymes at different stages of cell differentiation that presumably perform specialised functions. Confocal microscopic examination revealed the presence of PDE4A8 in primary and secondary spermatids but not in mature spermatozoa. PDE4A8 inhibition results in increased apoptosis of the germ cells accompanied with reduction in the number of mature spermatozoa.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3437R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3437R-A555
Lokale Artikelnummer::
BOSSBS-3437R-A555
Beschreibung:
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7896R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7896R-A555
Lokale Artikelnummer::
BOSSBS-7896R-A555
Beschreibung:
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9018R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9018R-A750
Lokale Artikelnummer::
BOSSBS-9018R-A750
Beschreibung:
Chromosome 7 is about 158 milllion bases long, encodes over 1000 genes and makes up about 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterised by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4041R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4041R-A555
Lokale Artikelnummer::
BOSSBS-4041R-A555
Beschreibung:
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8861R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8861R-A680
Lokale Artikelnummer::
BOSSBS-8861R-A680
Beschreibung:
STOML2 is a 356 amino acid member of the mec-2 family of proteins. Expressed ubiquitously at low levels, STOML2 is highly expressed in heart, liver and pancreas. STOML2 is localised to the cytoplasm with some distribution on the membrane. STOML2 was first identified as an overexpressed protein in human endometrial adenocarcinoma. Changes in cell growth in samples with different levels of STOML2 indicate that STOML2 could play a role in endometrial tumorigenesis. STOML2 is also thought to play a role in regulating ion channel conductances or the organisation of sphingolipid and cholesterol-rich lipid rafts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4148R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4148R-A750
Lokale Artikelnummer::
BOSSBS-4148R-A750
Beschreibung:
PKMYT1 is a member of the serine/threonine protein kinase family. It preferentially phosphorylates and inactivates cell division cycle 2 protein (cdc2), and thus acts as a negative regulator of entry into mitosis (G2 to M transition). It mediates phosphorylation of cdc2 predominantly on 'Thr-14' and is also involved in Golgi fragmentation. It may be involved in phosphorylation of cdc2 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. It may be a downstream target of Notch signaling pathway during eye development. PKMYT1 is negatively regulated by hyperphosphorylation during mitosis.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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