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3-Fluor-4-methoxybenzylamin
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3-Fluor-4-methoxybenzylamin
Artikel-Nr:
(BOSSBS-13515R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13515R-A750
Lokale Artikelnummer::
BOSSBS-13515R-A750
Beschreibung:
Tumor endothelial markers (TEMs) are abundantly expressed in the blood vessels of human solid tumors during angiogenesis and neoangiogensis. These include TEM1 (endosialin), TEM5 (G-protein coupled receptor 124) and TEM7 (plexin domain containing 1). TEMs are associated with the cell surface membrane at low levels in normal human and mouse tissues. TEM5 is a seven-pass transmembrane receptor, whereas TEM1, TEM7 and TEM8 span the membrane once. TEM5 expression is elevated during tumor angiogenesis and neoangiogenesis. TEM7 is highly expressed in tumor endothelium and neurons. Therefore, TEM5 and TEM7 may be suitable targets for the development of antiangiogenic therapies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13070R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13070R-A647
Lokale Artikelnummer::
BOSSBS-13070R-A647
Beschreibung:
The rTS gene codes for a naturally occurring antisense RNA to thymidylate synthase (TS) mRNA and two proteins (rTSalpha and rTSbeta (also known as ENOSF1)). The role of the major protein product of rTS, ENOSF1 has been linked to alterations in TS protein expression, but the precise function of ENOSF1 is unknown. Expression of rTS is associated with growth arrest in cell culture, but its overexpression has been noted in cells resistant to anticancer drugs such as 5-fluorouracil and methotrexate. Studies have shown that increased expression of ENOSF1 is associated with the decrease in TS protein expression due to production of novel, diffusible signal molecules.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13378R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13378R-A647
Lokale Artikelnummer::
BOSSBS-13378R-A647
Beschreibung:
GLT25D1 is a 622 amino acid protein that localizes to the lumen of the endoplasmic reticulum. Ubiquitously expressed with higher levels in placenta, heart, lung and spleen, GLT25D1 is a member of the glycosyltransferase 25 family. The beta-galactosyltransferase activity of GLT25D1 allows the transfer of beta-galactose to hydroxylysine residues of collagen. GLT25D1 is considered an important target for investigating the biological significance of collagen glycosylation and the importance of posttranslational modification in the etiology of connective tissue disorders. The gene encoding GLT25D1 is located on human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3746R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3746R-A555
Lokale Artikelnummer::
BOSSBS-3746R-A555
Beschreibung:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11728R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11728R-A488
Lokale Artikelnummer::
BOSSBS-11728R-A488
Beschreibung:
Epilepsy affects about 0.5% of the world’s population and has a large genetic component. Epilepsy results from an electrical hyperexcitability in the central nervous system. Potassium channels are important regulators of electrical signaling, determining the firing properties and responsiveness of a variety of neurons. Benign familial neonatal convulsions (BFNC), an autosomal dominant epilepsy of infancy, has been shown to be caused by mutations in the KCNQ2 or the KCNQ3 potassium channel genes. KCNQ2 and KCNQ3 are voltage-gated potassium channel proteins with six putative transmembrane domains. Both proteins display a broad distribution within the brain, with expression patterns that largely overlap.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13043R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13043R-A555
Lokale Artikelnummer::
BOSSBS-13043R-A555
Beschreibung:
The gene encoding DYX1C1 maps in the 15q21 region, which is disrupted by a translocation t(2;15)(q11;q21) and segregates with dyslexia. Two sequence changes in DYX1C1, including one involving the translation initiation sequence and an Elk-1 transcription factor binding site (-3G -->A) and a codon (1249G -->T), introduce a premature stop codon and truncate the protein by 4 amino acids. DYX1C1 encodes a nuclear tetratricopeptide repeat domain protein that is dynamically regulated in brain. In human brain, DYX1C1 protein localizes to a fraction of cortical neurons and white matter glial cells. It is also expressed in lung, kidney and testis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12461R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12461R-A488
Lokale Artikelnummer::
BOSSBS-12461R-A488
Beschreibung:
Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH9A1 (aldehyde dehydrogenase family 9 member A1), also known as E3, ALDH4, ALDH7, ALDH9 or TMABADH, is a 494 amino acid cytoplasmic protein that is highly expressed in adult liver, skeletal muscle, kidney and embryonic brain. ALDH9A1 converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine and catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in a NAD-dependent reaction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9032R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9032R-A350
Lokale Artikelnummer::
BOSSBS-9032R-A350
Beschreibung:
MAWDBP (MAWD binding protein), also known as PBLD (phenazine biosynthesis-like protein domain containing) or MAWBP, is a 288 amino acid protein that belongs to the phenazine biosynthesis-like protein (PhzF) family. It has been suggested that MAWDBP is the only representative of the PhzF family in the human genome. Expressed in most tissues, MAWDBP is a WD-40 repeat-containing β-propeller protein believed to participate in the MAPK signaling pathway. Involved in multiple basic cellular functions, expression of MAWDBP is elevated in several disease processes, including insulin resistance, folate deficiency and hypotension. It is thought that MAWDBP may also be involved in carcinogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3415R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3415R-A350
Lokale Artikelnummer::
BOSSBS-3415R-A350
Beschreibung:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0415R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0415R-A750
Lokale Artikelnummer::
BOSSBS-0415R-A750
Beschreibung:
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP1, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9483R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9483R-A647
Lokale Artikelnummer::
BOSSBS-9483R-A647
Beschreibung:
With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. The C5orf35 gene product has been provisionally designated C5orf35 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8346R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8346R-A488
Lokale Artikelnummer::
BOSSBS-8346R-A488
Beschreibung:
FGFR1OP2 belongs to the SIKE family. The FGFR1OP2 (FGFR1 oncogene partner 2) gene was identified through its involvement in a fusion with the FGFR1 gene. FGFR1OP2 may be involved in the wound healing pathway. It is expressed in bone marrow, spleen and thymus. A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T cell or B cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3479R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3479R-A350
Lokale Artikelnummer::
BOSSBS-3479R-A350
Beschreibung:
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5571R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5571R-A647
Lokale Artikelnummer::
BOSSBS-5571R-A647
Beschreibung:
The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3553R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3553R-A680
Lokale Artikelnummer::
BOSSBS-3553R-A680
Beschreibung:
RSK3(Ribosomal S6 kinase 3)is a member of a family of 90-kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases that are activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2. Rsk3 is a distinct isoform of p90Rsk that translocates to the cell nucleus, phosphorylates potential nuclear targets and may have a unique upstream activator. Several sites, such as Ser380, Thr359, Ser363 and Thr573, are important for its activation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9526R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9526R-A750
Lokale Artikelnummer::
BOSSBS-9526R-A750
Beschreibung:
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity).
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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