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4,4\\\'-Dibromoctafluorbiphenyl+(DBOB)
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4,4\\\'-Dibromoctafluorbiphenyl+(DBOB)
Artikel-Nr:
(BOSSBS-11200R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11200R-A750
Lokale Artikelnummer::
BOSSBS-11200R-A750
Beschreibung:
Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10362R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10362R-A680
Lokale Artikelnummer::
BOSSBS-10362R-A680
Beschreibung:
Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12522R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12522R-A750
Lokale Artikelnummer::
BOSSBS-12522R-A750
Beschreibung:
The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF-dependent regulatory mechanisms include the coordination of spectrin interactions with golgi membranes and the association of actin to the golgi via rho family-dependent G-protein localisation (Rac, CDC42) and WASP/Arp2/3 complexes. Additionally, ARFs play a central role in maintenance of organelle integrity, assembly of coat proteins, and activation of phospholipase D. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6); members of each class share a common gene organization. The human ARF6 gene maps to chromosome 7q22.1, contains five exons and four introns, and encodes a 175 amino acid protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3205R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3205R-CY5
Lokale Artikelnummer::
BOSSBS-3205R-CY5
Beschreibung:
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0573R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0573R-A350
Lokale Artikelnummer::
BOSSBS-0573R-A350
Beschreibung:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. Transcript Variant: This variant (1) contains a different 5' end region, which includes an upstream in-frame translation start codon, when compared to variant 2. The encoded protein has a 15 aa longer N-terminus, as compared to isoform 2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15181R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15181R
Lokale Artikelnummer::
BOSSBS-15181R
Beschreibung:
C3orf65 (chromosome 3 open reading frame 65) is a 143 amino acid protein encoded by a gene that maps to human chromosome 3q27.2. Chromosome 3 is made up of approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0481R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0481R-HRP
Lokale Artikelnummer::
BOSSBS-0481R-HRP
Beschreibung:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10460R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10460R-CY3
Lokale Artikelnummer::
BOSSBS-10460R-CY3
Beschreibung:
This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.[provided by RefSeq, May 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11035R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11035R-FITC
Lokale Artikelnummer::
BOSSBS-11035R-FITC
Beschreibung:
TNF Alpha-IP 8L2 (tumor necrosis factor, alpha-induced protein 8-like 2), also known as TIPE2, is a 184 amino acid protein that shares 94% identity with its mouse counterpart and belongs to the TNFAIP8 family. Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin, TNF Alpha-IP 8L2 plays a role in maintaining immune homeostasis, specifically by acting as a negative regulator of both innate and adaptive immunity. In addition, TNF?IP 8L2 functions as a negative regulator of T-cell receptor function and is thought to promote Fas-induced apoptosis. The gene encoding TNF?IP 8L2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6166R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6166R
Lokale Artikelnummer::
BOSSBS-6166R
Beschreibung:
Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1363R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1363R-A488
Lokale Artikelnummer::
BOSSBS-1363R-A488
Beschreibung:
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13724R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13724R-FITC
Lokale Artikelnummer::
BOSSBS-13724R-FITC
Beschreibung:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHB1 (Protocadherin beta 1) is an 818 amino acid protein that is one of 16 proteins in the protocadherin beta cluster. Unlike the alpha and gamma gene clusters whose genes are spliced to downstream constant region exons during transcription, members of the beta cluster (such as PCDHB1) do not use constant-region exons to produce mRNAs. As a result, each protocadherin beta gene encodes the transmembrane, extracellular and short cytoplasmic domains of the protein. PCDHB1 is a single-pass type I membrane protein containing six cadherin domains.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0095R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0095R-A647
Lokale Artikelnummer::
BOSSBS-0095R-A647
Beschreibung:
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7855R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7855R-HRP
Lokale Artikelnummer::
BOSSBS-7855R-HRP
Beschreibung:
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10366R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10366R-CY7
Lokale Artikelnummer::
BOSSBS-10366R-CY7
Beschreibung:
Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7613R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7613R-CY5.5
Lokale Artikelnummer::
BOSSBS-7613R-CY5.5
Beschreibung:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.Tissue specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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