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4,5-Dimethylpyridazine-3,6-diol
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4,5-Dimethylpyridazine-3,6-diol
Lieferant:
Thermo Scientific
Beschreibung:
Appearance: White to off-white Crystalline powder
Artikel-Nr:
(BOSSBS-13148R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13148R
Lokale Artikelnummer::
BOSSBS-13148R
Beschreibung:
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. A wide range of enzymes facilitate in the proteolytic Ub pathway, including monoclonal nonspecific suppressor factor-beta (MNSF-beta), a subunit of MNSF, which is a lymphokine product of a murine T cell hybrid-oma that restricts the production of LPS-induced immunoglobulin secreting cells in an antigen-nonspecific manner. MNSF-beta is a ubiquitin-like fusion protein consisting of the ribosomal protein S30 and a protein that shares 36% sequence identity with ubiquitin. This ubiquitin-like segment (Ubi-L) can be cleaved from MNSF-beta in the cytosol.
VE:
1 * 100 µl
Artikel-Nr:
(ELTN766231/45)
Lieferant:
ELTEN
Hersteller-Artikelnummer::
766231/45
Lokale Artikelnummer::
ELTN766231/45
Beschreibung:
ESD-Sicherheitsschuhe mit Obermaterial aus Rindleder und hydrophobiertem Nubukleder, einer geschlossenen, gepolsterten Lasche mit Mesh-Einsätzen aus Reflexmaterial und einer Zweischichten-PU/PU-Sohle.
VE:
1 * 1 PAAR
Artikel-Nr:
(ELTN768471/45)
Lieferant:
ELTEN
Hersteller-Artikelnummer::
768471/45
Lokale Artikelnummer::
ELTN768471/45
Beschreibung:
ESD-Sicherheitsstiefelette aus Rindslederschaft und Gummi/PU-Sohle (Wellmaxx Grip).
VE:
1 * 1 PAAR
New Product
Artikel-Nr:
(NALG322006-9025)
Lieferant:
Thermo Fisher Scientific
Hersteller-Artikelnummer::
322006-9025
Lokale Artikelnummer::
NALG322006-9025
Beschreibung:
Bottles with polypropylene closure used for safely storage and ship small volume samples and valuable reagents.
VE:
1 * 1.500 ST
Lieferant:
Alfa Aesar
Beschreibung:
Uridine 5′-monophosphate disodium salt 99%
Lieferant:
Alfa Aesar
Beschreibung:
Borwasserstoff-tert-Butylamin-Komplex 97%
Lieferant:
Biotium
Beschreibung:
Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DR and DP. Human MHC class II antigens are transmembrane glycoproteins composed of an chain (36 kDa) and a chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.
Lieferant:
Biotium
Beschreibung:
Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DR and DP. Human MHC class II antigens are transmembrane glycoproteins composed of an chain (36 kDa) and a chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.
Lieferant:
Biotium
Beschreibung:
This MAb reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
Artikel-Nr:
(BRDY217089)
Lieferant:
Brady
Hersteller-Artikelnummer::
217089
Lokale Artikelnummer::
BRDY217089
Beschreibung:
Matte, permanent self-laminating and wrap-around B-461 polyester labels for smooth surfaces. For use on conical tubes, cryo tubes and vials. Suitable for autoclaves, hot wwater baths (100 °C) and cryo or liquid nitrogen applications.
VE:
1 * 1 Rolle
Lieferant:
Thermo Scientific
Beschreibung:
Chromotropsäure Dinatriumsalz Dihydrat ACS
Artikel-Nr:
(215643-5G)
Lieferant:
SIGMA ALDRICH MICROSCOPY
Hersteller-Artikelnummer::
215643-5G
Lokale Artikelnummer::
SIAM215643-5G
Beschreibung:
Disperse blue 1 is a grey to black powder. Disperse dyes are known to be insoluble in water and are applied to the substrate as suspensions or dispersions by dissolving in hydrophobic regions of the polymers making up the fiber.
VE:
1 * 5 g
Artikel-Nr:
(BOSSBS-6943R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6943R-CY5
Lokale Artikelnummer::
BOSSBS-6943R-CY5
Beschreibung:
F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and protein recruitment. F-box proteins are members of a large family that regulate the cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, for degradation by the proteasome after ubiquitination. FBL11, also known as FBXL11 (F-box and leucine-rich repeat protein 11), CXXC8, KDM2A, JHDM1A (JmjC domain-containing histone demethylation protein 1A) or LILINA, is a 1,162 amino acid member of the F-box protein family that contains one F-box domain and localizes to the nucleus. Expressed ubiquitously with highest expression in testis, ovary and brain, FBL11 functions to demethylate the Lys-36 residue of histone H3, thereby modulating the histone code. Additionally, FBL11 is thought to promote the ubiquitination and subsequent degradation of various phosphorylated proteins. Three isoforms of FBL11 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6943R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6943R-CY7
Lokale Artikelnummer::
BOSSBS-6943R-CY7
Beschreibung:
F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and protein recruitment. F-box proteins are members of a large family that regulate the cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, for degradation by the proteasome after ubiquitination. FBL11, also known as FBXL11 (F-box and leucine-rich repeat protein 11), CXXC8, KDM2A, JHDM1A (JmjC domain-containing histone demethylation protein 1A) or LILINA, is a 1,162 amino acid member of the F-box protein family that contains one F-box domain and localizes to the nucleus. Expressed ubiquitously with highest expression in testis, ovary and brain, FBL11 functions to demethylate the Lys-36 residue of histone H3, thereby modulating the histone code. Additionally, FBL11 is thought to promote the ubiquitination and subsequent degradation of various phosphorylated proteins. Three isoforms of FBL11 exist due to alternative splicing events.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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