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2,3-Difluoro-4-methoxycinnamic+acid
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2,3-Difluoro-4-methoxycinnamic+acid
Artikel-Nr:
(PRSI33-932)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-932
Lokale Artikelnummer::
PRSI33-932
Beschreibung:
Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
VE:
1 * 100 µG
Lieferant:
Agilent
Beschreibung:
CrossLab piston seal, reversed-phase, Für: Thermo UltiMate 3000 RS and SD pump series
Lieferant:
Restek
Beschreibung:
Diese MXT-5-Säulen bestehen aus mit Siltek behandeltem Edelstahl mit einer Phase mit niedriger Polarität und einer stationären Diphenyl-Dimethylpolysiloxan-Phase mit Kreuzbindung. Alle restlichen Katalysatoren und Fragmente mit niedrigem Molekulargewicht werden aus dem MXT-5-Polymer entfernt, was zu einer engen monomodalen Verteilung und extrem geringem Ausbluten führt.
Lieferant:
HAMILTON BONADUZ
Beschreibung:
PRP-3 polymeric reversed phase columns are ideal for gradient separations of peptides and proteins. The columns are packed with a poly(styrene-divinyl)benzene support.
Lieferant:
VARIAN
Beschreibung:
Aminomethylstyrene resin is a particularly versatile material suitable for the attachment of a variety of spacers, handles and linkers (for use in solid phase synthesis).
Lieferant:
Thermo Fisher Scientific
Beschreibung:
These sulfonamide embedded, reversed phase columns provide unique selectivity and excellent peak shape for acidic, basic, and neutral analytes. Efficient for the separations of nucleic acid and bases or pharmaceutical compounds using highly aqueous mobile phases.
Lieferant:
Restek
Beschreibung:
Highly retentive propyl cyano phase. Excellent choice for basic compounds and for analytes containing amine group functionality.
Artikel-Nr:
(HEWL124-0034)
Lieferant:
Agilent
Hersteller-Artikelnummer::
124-0034
Lokale Artikelnummer::
HEWL124-0034
Beschreibung:
Agilent provides the DB-MTBE GC column with a low polarity stationary phase which resolves MTBE from 2-methylpentane and 3-methylpentane for better quantitation.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-9301R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9301R-HRP
Lokale Artikelnummer::
BOSSBS-9301R-HRP
Beschreibung:
SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle; it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2993R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2993R-CY5
Lokale Artikelnummer::
BOSSBS-2993R-CY5
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI79-166)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-166
Lokale Artikelnummer::
PRSI79-166
Beschreibung:
Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
VE:
1 * 100 µG
Lieferant:
VARIAN
Beschreibung:
Bond Elut™ C18 OH is a non-end capped version of the octadecyl bonded phases that enables the silanols on the silica surface to be more active. This low-load C18 has well-controlled silanol activity that permits the fractionation of metabolites and enhances retention of basic compounds compared to an endcapped C18. The pore size makes it a good choice for peptide extraction.
Artikel-Nr:
(BOSSBSM-0391M-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BSM-0391M-A680
Lokale Artikelnummer::
BOSSBSM-0391M-A680
Beschreibung:
C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture. .
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3195R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3195R-A555
Lokale Artikelnummer::
BOSSBS-3195R-A555
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2993R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2993R-HRP
Lokale Artikelnummer::
BOSSBS-2993R-HRP
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2993R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2993R-A680
Lokale Artikelnummer::
BOSSBS-2993R-A680
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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