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1-Bromo-3-(2,2-difluoropropyl)benzene
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1-Bromo-3-(2,2-difluoropropyl)benzene
Artikel-Nr:
(PRSI25-857)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-857
Lokale Artikelnummer::
PRSI25-857
Beschreibung:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE3B is a member of the E3 ubiquitin-conjugating enzyme family. UBE3B may interact with other proteins and play a role in stress response.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family. The encoded protein may interact with other proteins and play a role in stress response. Alternatively spliced transcript variants encoding the same protein isoform have been identified for this gene.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3551)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3551
Lokale Artikelnummer::
PRSI3551
Beschreibung:
Adiponectin Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. It is present in high levels in normal human plasma, but is reduced in obese subjects and often in those with increased insulin resistance and type 2 diabetes, suggesting that adiponectin may be a useful pharmacological target in various metabolic diseases.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI60-765)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
60-765
Lokale Artikelnummer::
PRSI60-765
Beschreibung:
For WB starting dilution is: 1:1000.
VE:
1 * 400 µl
Artikel-Nr:
(PRSI27-935)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-935
Lokale Artikelnummer::
PRSI27-935
Beschreibung:
FOXQ1 contains 1 fork-head DNA-binding domain. FOXQ1 mediates the interaction of Akt/protein kinase B with TGFb2. Foxq1 regulates differentiation of hair in satin mice.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI76-274)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-274
Lokale Artikelnummer::
PRSI76-274
Beschreibung:
The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa epsilon chain of the TCR complex. Together with the gamma and delta subunits of CD3, the epsilon subunits are involved in the assembly, trafficking, and surface expression of T-cell receptor complex. CD3 is expressed on thymocytes, mature T cells, and natural killer T cells, and the epsilon chain enhances the antigen recognition.The 145-2C11 antibody binds to the TCR complex and, depending on the conditions, initiates T cells activation, proliferation, and apoptosis. The soluble antibody seems to block lysis of target cells by antigen-specific cytotoxic T lymphocytes. The 145-2C11 antibody does not cross-react with the rat leukocytes, and it is used as a phenotypic marker for mouse T lymphocytes.
VE:
1 * 0,025 mg
Artikel-Nr:
(PRSI3145)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3145
Lokale Artikelnummer::
PRSI3145
Beschreibung:
PHAP I Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI92-267)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-267
Lokale Artikelnummer::
PRSI92-267
Beschreibung:
Ferritin heavy polypeptide 1(FTH1), is a ubiquitous intracellular protein which stores iron in a soluble, non-toxic, readily available form. FTH1 has ferroxidase activity and is important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Ferritin is composed of 24 subunits of the light and heavy ferritin chains. It plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney. Variation of ferritin subunit composition may affect iron absorption and release in different tissues. Deficiency of ferritin proteins may cause several neurodegenerative diseases. Almost all living organisms can produce this protein, including algae, bacteria, higher plants, and animals.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI22-183)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
22-183
Lokale Artikelnummer::
PRSI22-183
Beschreibung:
Anti-SERPINB9 Rabbit Polyclonal Antibody
VE:
1 * 50 µl
Artikel-Nr:
(PRSI33-108)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-108
Lokale Artikelnummer::
PRSI33-108
Beschreibung:
This antibody recognises a 27 kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. The p27Kip1 antibody is highly specific and shows no cross-reaction with other related mitotic inhibitors. p27Kip1 functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. It is a candidate tumor suppressor gene. This mAb is excellent for staining of formalin-fixed tissues.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI29-235)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-235
Lokale Artikelnummer::
PRSI29-235
Beschreibung:
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control.This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI23-884)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
23-884
Lokale Artikelnummer::
PRSI23-884
Beschreibung:
Anti-AKR1D1 Rabbit Polyclonal Antibody
VE:
1 * 50 µl
Artikel-Nr:
(PRSI23-634)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
23-634
Lokale Artikelnummer::
PRSI23-634
Beschreibung:
Anti-RNF34 Rabbit Polyclonal Antibody
VE:
1 * 50 µl
Artikel-Nr:
(PRSI60-930)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
60-930
Lokale Artikelnummer::
PRSI60-930
Beschreibung:
For WB starting dilution is: 1:1000.
VE:
1 * 400 µl
Artikel-Nr:
(PRSI63-714)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
63-714
Lokale Artikelnummer::
PRSI63-714
Beschreibung:
For WB starting dilution is: 1:1000. For FACS starting dilution is: 1:10~50.
VE:
1 * 400 µl
Artikel-Nr:
(PRSI62-781)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
62-781
Lokale Artikelnummer::
PRSI62-781
Beschreibung:
For WB starting dilution is: 1:1000. For IHC-P starting dilution is: 1:10~50.
VE:
1 * 400 µl
Artikel-Nr:
(PRSI79-109)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-109
Lokale Artikelnummer::
PRSI79-109
Beschreibung:
NF-κ-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-κ-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-κ-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-κ-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-κ-B complex which translocates to the nucleus. NF-κ-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-κ-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-κ-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-κ-B complex.
VE:
1 * 100 µG
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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