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Lieferant:
ENTEGRIS
Beschreibung:
Die sichere und bequeme Methode zur Verbindung von wiederverwendbaren FluoroPure®-Chemikalienbehältern mit Großmengenabgabesystemen. Das patentierte Design Keycode, um ein unsicheres Mischen von Chemikalien zu verhindern und gleichzeitig einen engagierten sauberen Service zu gewährleisten. Ein Anschluss ermöglicht die Abgabe, Entlüftung und Füllstandserkennung.
Artikel-Nr:
(BOSSBS-0235R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0235R-CY3
Lokale Artikelnummer::
BOSSBS-0235R-CY3
Beschreibung:
PMP22 is a 22 kDa glycoprotein expressed in the compact myelin of the peripheral nervous system. In the peripheral nervous system, PMP 22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) during nerve development and regeneration. Alterations in the level of this protein cause several genetic human diseases. If the protein is duplicated, patients develop Charcot Marie Tooth disease. If one copy of the gene is deleted, they suffer from the inherited tendency to pressure palsies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0235R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0235R-CY5
Lokale Artikelnummer::
BOSSBS-0235R-CY5
Beschreibung:
PMP22 is a 22 kDa glycoprotein expressed in the compact myelin of the peripheral nervous system. In the peripheral nervous system, PMP 22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) during nerve development and regeneration. Alterations in the level of this protein cause several genetic human diseases. If the protein is duplicated, patients develop Charcot Marie Tooth disease. If one copy of the gene is deleted, they suffer from the inherited tendency to pressure palsies.
VE:
1 * 100 µl
Artikel-Nr:
(APOSOR33491-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR33491-1G
Lokale Artikelnummer::
APOSOR33491-1G
Beschreibung:
2,2,2-Trichloro-1-[4-(1-hydroxypropyl)-1H-pyrrol-2-yl]-1-ethanone 95%
VE:
1 * 1 g
Artikel-Nr:
(BLDPBD2557-25G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD2557-25G
Lokale Artikelnummer::
BLDPBD2557-25G
Beschreibung:
4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol 95%
VE:
1 * 25 g
Artikel-Nr:
(BOHLF763-08)
Lieferant:
Bohlender
Hersteller-Artikelnummer::
F763-08
Lokale Artikelnummer::
BOHLF763-08
Beschreibung:
Straight UNF screw-in tube fitting made of PTFE. One side with fitting thread GL 14 for connecting hard-walled tubes and tubing by means of BOLA Laboratory Screw Joints. Other side with male screw-in thread UNF 1/4 28G for connection to units and fittings with female thread UNF 1/4 28G.
VE:
1 * 1 ST
Artikel-Nr:
(BSENR-1694-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
R-1694-100
Lokale Artikelnummer::
BSENR-1694-100
Beschreibung:
The spectrin family of proteins were originally discovered as major components of the submembraneous cytoskeleton of osmotically lysed red blood cells (1). The lysed blood cells could be seen as clear red blood cell shaped objects in the light microscope and were referred to as red cell "ghosts". The major proteins of these ghosts proved to be actin, ankyrin, band 4.1 and several other proteins, including two major bands running at about 240kDa and 260kDa on SDS-PAGE gels. This pair of bands was named "spectrin" since they were discovered in these red blood cell ghosts (1). Later work showed that similar high molecular bands were seen in membrane preparations from other eukaryotic cell types. Work by Levine and Willard described a pair of about ~240-260kDa molecular weight bands which were transported at the slowest rate along mammalian axons (2). They named these proteins "fodrin" as antibody studies showed that they were localized in the sheath under the axonal membrane, but not in the core of the axon (2; fodros is Greek for sheath). Subsequently fodrin was found to be a member of the spectrin family of proteins, and the spectrin nomenclature is now normally used (3). Spectrins form tetramers of two alpha and two beta subunits, with the alpha corresponding to the lower molecular weight ~240kDa band and the beta corresponding to the ~260kDa or in some case much larger band. Most spectrin tetramers are about 0.2microns or 200nm long, and each alpha and beta subunit has a cell type specific expression pattern. The basic structure of each spectrin subunit is the spectrin repeat, which is a sequence of about 110 amino acids which defines a compact domain contain three closely packed alpha-helices. Each spectrin subunit contains multiple copies of this repeat, with 20 in each of the alpha subunits. The beta I-IV subunits each contain 17 spectrin repeats, while the beta V subunit, also known as beta-heavy spectrin, contains 30 of these repeats. The various subunits also contain several other kinds of functional domain, allowing the spectrin tetramer to interact with a variety of protein, ionic and lipid targets. The alpha-subunits each contain one calmodulin like calcium binding region and one Src-homology 3 (SH3) domain, an abundant domain involved in specific protein-protein interactions. The beta subunits all have a N-terminal actin binding domain and may also have one SH3 domain and one pleckstrin homology domain, a multifunctional type of binding domain which in beta I spectrin at least binds the membrane lipid PIP2 (5). Spectrins are believed to have a function in giving mechanical strength to the plasma membrane since the tetramers associate with each other to form a dense submembraneous geodesic meshwork (3). They also bind a variety of other membrane proteins and membrane lipids, and the proteins they bind to are therefore themselves localized in the membrane. Diseases may be associated with defects in one or other of the spectrin subunits (6). For example, some forms of hereditary spherocytosis, the presence of spherical red blood cells which are prone to lysis, can be traced to mutations in some of the spectrin subunits (7). The alpha-II subunit is widely expressed in tissues but, in the nervous system, is found predominantly in neurons. The antibody can therefore be used to identify neurons and fragments derived from neuronal membranes in cells in tissue culture and in sectioned material.
VE:
1 * 100 µl
Artikel-Nr:
(BLDPBD84944-1G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD84944-1G
Lokale Artikelnummer::
BLDPBD84944-1G
Beschreibung:
3-Bromo-5-(trifluoromethyl)pyridin-2-ol 98%
VE:
1 * 1 g
Lieferant:
Thermo Scientific
Beschreibung:
2-Imidazolidinon Hemihydrat 99+%
Artikel-Nr:
(BOSSBS-12260R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12260R-CY3
Lokale Artikelnummer::
BOSSBS-12260R-CY3
Beschreibung:
The proteasome represents a large protein complex that exists inside all eukaryotes and archaea, and in some bacteria. The main function of proteasomes is to degrade unnecessary or damaged proteins by proteolysis. The most common form of the proteasome, known as the 26S Proteasome, contains one 20S Proteasome core particle structure and two 19S regulatory caps. The 20S Proteasome core is hollow and forms an enclosed cavity, where proteins are degraded, as well as openings at the two ends to allow the target protein to enter. The 20S Proteasome core particle contains many subunits, depending on the organism. All of the subunits fall into one of two types: alpha subunits, which are structural, serve as docking domains for the regulatory particles and exterior gates blocking unregulated access to the interior cavity; or beta subunits, which are predominantly catalytic. The outer two rings in the proteasome consist of seven ?subunits each, and the inner two rings each consist of seven beta subunits.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11210R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11210R-HRP
Lokale Artikelnummer::
BOSSBS-11210R-HRP
Beschreibung:
Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex transports cellular cargos towards the central region of the cell. Axonemal dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH9 (Dynein, axonemal, heavy chain 9), also known as DYH9, HL20, DNEL1, Dnahc9 or DNAH17L, is a member of the Dynein heavy chain family and comprises one of the heavy chain subunits of axonemal Dynein. DNAH9 consists of an N-terminal stem which is responsible for interacting with other Dynein components and binding cargo, and four P-loops that comprise the motor domain at its C-terminus.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15434R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15434R-A555
Lokale Artikelnummer::
BOSSBS-15434R-A555
Beschreibung:
HD-PTP is a 1636 amino acid protein encoded by the human gene PTPN23. HD-PTP belongs to the protein-tyrosine phosphatase family, non-receptor class subfamily. It contains one BRO1 domain, two TPR repeats and one tyrosine-protein phosphatase domain. The C-terminal region contains the PTP-like domain, whereas the N-terminal region contains the two TPR regions. These regions are homologous to the yeast protein, BRO1, which is involved in the mitogen-activated protein kinase signaling pathway. Similarly, HD-PTP is believed to act as a negative regulator of Ras-mediated mitogenic activity and is phosphorylated upon DNA damage, probably by ATM or ATR. HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor (VEGF) has no affect on protein levels, Fibroblast Growth Factor-2 (FGF-2) induces HD-PTP degradation via the proteasome system.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13120R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13120R-A680
Lokale Artikelnummer::
BOSSBS-13120R-A680
Beschreibung:
The exosome is a multi-subunit complex composed of several highly conserved proteins, some of which are 3? to 5? exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3? region. EXOSC10, also known as PMSCL, PMSCL2, p2, p3, p4, RRP6, Rrp6p, PM-Scl, or PM/Scl-100, is an 885 amino acid protein that contains one HRDC domain and one 3?-5? enonuclease domain. Localized to both the cytoplasm and the nucleus, EXOSC10 is part of the post-splicing exosome complex and is involved in mRNA surveillance, mRNA nuclear export and nonsense-mediated decay of mRNAs containing premature stop codons. against EXOSC10 have been found in patients with scleroderma and/or polymyositis (chronic diseases of the skin and muscle, respectively), suggesting that EXOSC10 may be involved in the pathogenesis of these diseases. Two isoforms of EXOSC10 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12217R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12217R-HRP
Lokale Artikelnummer::
BOSSBS-12217R-HRP
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF263 (Zinc finger protein 263), also known as FPM315 or ZKSCAN12 (Zinc finger protein with KRAB and SCAN domains 12), is a 683 amino acid nuclear protein that contains nine C2H2-type zinc fingers, one KRAB domain and one SCAN box domain. ZNF263 acts as a transcriptional repressor in the nucleus and is expressed in various tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9061R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9061R-A488
Lokale Artikelnummer::
BOSSBS-9061R-A488
Beschreibung:
Teneurin-3, also known as Ten-3, TNM3 or ODZ3, is a 2,699 amino acid single-pass type II membrane protein that contains 25 YD repeats, 8 EGF-like domains, 5 NHL repeats and one teneurin N-terminal domain. Localized to the membrane and expressed in brain, testis and ovary, Teneurin-3 exists as a disulfide-liked homodimer that is thought to function as a cellular signal transducer. Additionally, Teneurin-3 may participate in eye-specific patterning in the visual pathway and is required for aligned binocular vision. The gene encoding Teneurin-3 maps to chromosome 4. Representing approximately 6% of the human genome, chromosome 4 contains nearly 900 genes, one of which is the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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