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4-Bromo-3,5-dimethylisoxazole
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4-Bromo-3,5-dimethylisoxazole
Artikel-Nr:
(BOSSBS-4838R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4838R-CY3
Lokale Artikelnummer::
BOSSBS-4838R-CY3
Beschreibung:
HE4 is a broad range protease inhibitor. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11690R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11690R-HRP
Lokale Artikelnummer::
BOSSBS-11690R-HRP
Beschreibung:
FIG4 is a 907 amino acid protein that contains one SAC domain through which it is thought to function as a phosphoinositide phosphatase that may play an important role in signal transduction and vesicle trafficking. Defects in the gene encoding FIG4 are the cause of Charcot-Marie-Tooth disease type 4J (CMT4J) and amyotrophic lateral sclerosis type 11 (ALS11), both of which negatively affect the nervous system. CMT4J is a recessive demyelinating disorder of the peripheral nervous system and is characterized by reduced motor nerve conduction velocities and axonal degeneration. Unlike CMT4J, ALS11 is characterized by the degeneration of upper motor neurons in the brain and lower neurons in the spinal cord, causing paralysis and, ultimately, death.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6273R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6273R-HRP
Lokale Artikelnummer::
BOSSBS-6273R-HRP
Beschreibung:
Enolase 1 is a multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.Enolase 2 has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.Enolase 3 appears to have a function in striated muscle development and regeneration.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
PP. Designed for high throughput PCR, this 384-well plate is compatible with the majority of 384 block PCR and sequencing instruments. The full skirt and rigid plate deck minimise distortion during PCR making it suitable for use with robotic systems.
Artikel-Nr:
(BOSSBS-11963R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11963R
Lokale Artikelnummer::
BOSSBS-11963R
Beschreibung:
There are three SorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, SorCS1, SorCS2 and SorCS3 genes are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS2 (sortilin-related VPS10 domain containing receptor 2) is a 1,150 amino acid single-pass type I membrane protein that is highly expressed in brain and kidney. Containing six BNR repeats and a single PKD domain, SorCS2 is encoded by a gene that maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15464R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15464R-CY7
Lokale Artikelnummer::
BOSSBS-15464R-CY7
Beschreibung:
HERPUD1 is a includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined.
VE:
1 * 100 µl
Lieferant:
KNF
Beschreibung:
Die modularen SC Systeme sind mit einer chemiefesten Membranpumpe ausgestattet. Die Vakuumsysteme finden ein weites Anwendungsfeld in Laboratorien überall dort, wo sauberes und konstantes Vakuum benötigt wird. Für den entsprechenden Anwendungsfall im Labor stehen Vakuumpumpen mit unterschiedlichen Leistungsgrößen und verschiedenen, modularen Systemkomponenten zur Wahl.
Artikel-Nr:
(BOSSBS-10109R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10109R-A647
Lokale Artikelnummer::
BOSSBS-10109R-A647
Beschreibung:
Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5421R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5421R-A555
Lokale Artikelnummer::
BOSSBS-5421R-A555
Beschreibung:
Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5417R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5417R-CY5
Lokale Artikelnummer::
BOSSBS-5417R-CY5
Beschreibung:
Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11190R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11190R-HRP
Lokale Artikelnummer::
BOSSBS-11190R-HRP
Beschreibung:
C9 is a plasma protein synthesized in the liver and monocytes consisting of a single polypeptide chain. C9 is a part of the membrane attack complex (MAC), an important component of the immune system. The MAC forms upon complement system activation by invading pathogenic bacteria and consists of the four major complement proteins: C5b, C6, C7 and C8. These complement proteins bind to the outer surface of the plasma membrane of the invading cell. C9 binds to the membrane associated C5b-8 protein, which leads to the circular polymerization of 12-18 C9 molecules. These polymerized C9 molecules form a ring structure in the membrane. Molecules can then diffuse freely through this transmembrane channel, causing cell lysis and destruction of the invading bacterial cell.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7084R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7084R-A647
Lokale Artikelnummer::
BOSSBS-7084R-A647
Beschreibung:
Defects in NOD2 are the cause of sarcoidosis early-onset (EOS) . EOS is a form of sarcoidosis manifesting in children younger than 4 years of age. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Early-onset sarcoidosis is quite rare and has a distinct triad of skin, joint and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, early-onset sarcoidosis is progressive and in many cases causes severe complications, such as blindness, joint destruction and visceral involvement.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0693R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0693R-A680
Lokale Artikelnummer::
BOSSBS-0693R-A680
Beschreibung:
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5473R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5473R-A488
Lokale Artikelnummer::
BOSSBS-5473R-A488
Beschreibung:
Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7084R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7084R-A488
Lokale Artikelnummer::
BOSSBS-7084R-A488
Beschreibung:
Defects in NOD2 are the cause of sarcoidosis early-onset (EOS) . EOS is a form of sarcoidosis manifesting in children younger than 4 years of age. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Early-onset sarcoidosis is quite rare and has a distinct triad of skin, joint and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, early-onset sarcoidosis is progressive and in many cases causes severe complications, such as blindness, joint destruction and visceral involvement.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10110R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10110R-CY5
Lokale Artikelnummer::
BOSSBS-10110R-CY5
Beschreibung:
Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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