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6-Fluoro-2-methylnicotinic+acid
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6-Fluoro-2-methylnicotinic+acid
Artikel-Nr:
(BOSSBS-8510R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8510R-A555
Lokale Artikelnummer::
BOSSBS-8510R-A555
Beschreibung:
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1444R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1444R-A488
Lokale Artikelnummer::
BOSSBS-1444R-A488
Beschreibung:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4091R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4091R-A680
Lokale Artikelnummer::
BOSSBS-4091R-A680
Beschreibung:
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4038R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4038R-A488
Lokale Artikelnummer::
BOSSBS-4038R-A488
Beschreibung:
SLC25A13 is a member of the mitochondrial carrier family. It contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. It catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in the SLC25A13 gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8536R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8536R-A680
Lokale Artikelnummer::
BOSSBS-8536R-A680
Beschreibung:
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6016R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6016R-A350
Lokale Artikelnummer::
BOSSBS-6016R-A350
Beschreibung:
In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4091R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4091R-A647
Lokale Artikelnummer::
BOSSBS-4091R-A647
Beschreibung:
ADP-ribosylation factor (Arf) family of small GTP-binding proteins plays a central role in membrane trafficking and cytoskeletal remodeling. ASAP1 (Arf-GAP containing SH3, ankyrin repeats and PH domain) is a phospholipid-dependent Arf GTPase-activating protein that binds to the protein-tyrosine kinases Src and focal adhesion kinase. ASAP1 may act as an oncogene in cancer, and it may be a useful diagnostic marker and therapeutic target.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9412R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9412R-A680
Lokale Artikelnummer::
BOSSBS-9412R-A680
Beschreibung:
TSPAN3 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell surface proteins that are characterised by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Two alternative transcripts encoding different isoforms have been described.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9596R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9596R-A750
Lokale Artikelnummer::
BOSSBS-9596R-A750
Beschreibung:
SPAG17 (sperm associated antigen 17), also known as PF6, is a 2223 amino acid cytoplamic protein that colocalizes with SPAG6 to microtubles. Highly expressed in testis and in organs that contain cilia-bearing cells including brain, oviduct, lung, and uterus, SPAG17 may be important for the structural integrity of the central apparatus of the sperm axoneme. SPAG17 contains two LRR (leucine-rich) repeats and may also participate in flagellar motility and male fertility.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9596R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9596R-A680
Lokale Artikelnummer::
BOSSBS-9596R-A680
Beschreibung:
SPAG17 (sperm associated antigen 17), also known as PF6, is a 2223 amino acid cytoplamic protein that colocalizes with SPAG6 to microtubles. Highly expressed in testis and in organs that contain cilia-bearing cells including brain, oviduct, lung, and uterus, SPAG17 may be important for the structural integrity of the central apparatus of the sperm axoneme. SPAG17 contains two LRR (leucine-rich) repeats and may also participate in flagellar motility and male fertility.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2976R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2976R-A680
Lokale Artikelnummer::
BOSSBS-2976R-A680
Beschreibung:
Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolysed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyse a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defence mechanism. Isoform 3 seems to be inactive.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9628R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9628R-A750
Lokale Artikelnummer::
BOSSBS-9628R-A750
Beschreibung:
C16orf44 is a 616 amino acid protein that contains six Kelch repeats, one BTB/POZ domain and one BTB/Kelch associated (BACK) domain. C16orf44 is believed to play a role in protein ubiquitination and may function as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, C16orf44 interacts with CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Due to alternative splicing events, two isoforms of C16orf44 are expressed.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12937R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12937R-A750
Lokale Artikelnummer::
BOSSBS-12937R-A750
Beschreibung:
CTBS is an evolutionarily conserved member of the glycosyl hydrolase 18 family of proteins. Localizing to the lysosome, CTBS plays a role in the degradation of asparagine-linked (Asn-linked) glycoproteins. Glycoproteins are translocated to lysosomes via endocytosis or autophagy where they are broken down by proteases and glycosidases. The catabolism of glycoproteins is an important step in the regular turnover of cellular contents and in maintaining the homeostasis of glycosylation. CTBS functions as a glycosidase that cleaves the reducing end GlcNAc from the core chitobiase unit of oligosaccharides. Before this reaction can occur, AGA (the lysosomal glycosylasparaginase) must first remove the Asn from the Asn-linked glycoprotein to expose the reducing end GlcNAc, thereby allowing CTBS to access the exposed moiety.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11472R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11472R-A350
Lokale Artikelnummer::
BOSSBS-11472R-A350
Beschreibung:
RSHL3 is predicted to be a component of the radial spoke head based on homology with proteins in the biflagellate alga Chlamydomonas reinhardtii and other ciliates. RSHL3 (radial spoke head-like protein 3), also known as radial spoke head protein 4 homolog A, is a 716 amino acid protein that belongs to the flagellar radial spoke RSP4/6 family. Mutations in the RSHL3 gene cause primary ciliary dyskinesia 1, a disease arising from dysmotility of motile cilia and sperm. Existing as three alternatively spliced isoforms, the RSHL3 gene contains 6 exons, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly and P.falciparum, and maps to human chromosome 6q22.1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11196R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11196R-A350
Lokale Artikelnummer::
BOSSBS-11196R-A350
Beschreibung:
The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including catenin b, to regulate cadherin function. R-cadherin (for retinal-cadherin, also designated cadherin-4), which was first identified in the retina of chicken, has been shown to be involved in the development of striated muscle and potentially epithelia in addition to its involvement in retinal development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9971R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9971R-A680
Lokale Artikelnummer::
BOSSBS-9971R-A680
Beschreibung:
Interacts with phosphorylated C-terminal heptapeptiderepeat domain (CTD) of the largest RNA polymerase II subunitPOLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1.Promotes binding of RNA polymerase II to the CCDN1 promoter and tothe termination region before the poly-A site but decreases itsbinding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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