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4-Fluorobenzo[d]thiazol-2(3H)-one
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4-Fluorobenzo[d]thiazol-2(3H)-one
Artikel-Nr:
(BOSSBS-12099R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12099R-CY7
Lokale Artikelnummer::
BOSSBS-12099R-CY7
Beschreibung:
MPDZ is a 2,042 amino acid peripheral membrane protein that colocalizes with SR-2C on the apical membrane of epithelial choroid plexus cells. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas, MPDZ causes clustering of SR-2C, a serotonin receptor, at the cell surface. MPDZ is member of the NMDAR signaling complex that is involved in regulating AMPAR potentiation and synaptic plasticity in excitatory synapses. As a tight junction protein in epithelial cells, MPDZ interacts with SSTR3, a G-protein-coupled receptor, to regulate transepithelial permeability in a pertussis toxin sensitive manner. MPDZ, along with Kir4.2, may form a complex with other proteins in the nephron and regulate ion transport. MPDZ contains one L27 domain and thirteen PDZ domains.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11150R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11150R-CY5
Lokale Artikelnummer::
BOSSBS-11150R-CY5
Beschreibung:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin (PCDH) gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHGA9 (Protocadherin gamma-A9) is a 932 amino acid that is one of 22 proteins encoded by the protocadherin gamma cluster. The protocadherein gamma cluster consists of three subfamilies (A, B and C) and PCDHGA9 is a member of the gamma subfamily A. PCDHGA9 is a type I transmembrane receptor containing six cadherin motifs and is expressed in the central nervous system where it localizes to synapses. Members of the gamma cluster of protocadherins are essential for neuronal survival. There are two isoforms of PCDHGA9 that are produced as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9337R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9337R
Lokale Artikelnummer::
BOSSBS-9337R
Beschreibung:
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH3 (membrane-associated ring finger (C3HC4) 3), also known as RNF173, is a 253 amino acid multi-pass membrane protein that localizes to cytoplasmic vesicles and early endosomes and contains one RING-CH-type zinc finger. Involved in the pathway of protein modification, MARCH3 functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to be involved in endosomal trafficking events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11155R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11155R
Lokale Artikelnummer::
BOSSBS-11155R
Beschreibung:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. The protocadherein gamma cluster consists of three subfamilies (A, B and C). As a member of the gamma subfamily B, PCDHGB1 (Protocadherin gamma B1) is a 927 amino acid protein that is one of 22 proteins encoded by the protocadherin gamma cluster. Typical of gamma protocadherins, PCDHGB1 contains six cadherin motifs and is a type I transmembrane receptor expressed in the central nervous system. With localization to synapses, members of the gamma cluster of protocadherins are essential for neuronal survival. There are two isoforms of PCDHGB1 that are produced as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11340R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11340R-CY3
Lokale Artikelnummer::
BOSSBS-11340R-CY3
Beschreibung:
The regulated translation of messenger RNA is essential for cell-cycle progression, establishment of the body plan during early development and modulation of key activities in the central nervous system. Cytoplasmic polyadenylation, one mechanism of controlling translation, is driven by cytoplasmic polyadenylation element binding proteins, called CPEBs. CPEB3 (cytoplasmic polyadenylation element binding protein 3) is a 698 amino acid protein that contains two RNA recognition motif (RRM) domains and, like other CPEB proteins, may play a role in the maturation of the central nervous system. CPEB3 exists as multiple alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12099R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12099R-CY3
Lokale Artikelnummer::
BOSSBS-12099R-CY3
Beschreibung:
MPDZ is a 2,042 amino acid peripheral membrane protein that colocalizes with SR-2C on the apical membrane of epithelial choroid plexus cells. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas, MPDZ causes clustering of SR-2C, a serotonin receptor, at the cell surface. MPDZ is member of the NMDAR signaling complex that is involved in regulating AMPAR potentiation and synaptic plasticity in excitatory synapses. As a tight junction protein in epithelial cells, MPDZ interacts with SSTR3, a G-protein-coupled receptor, to regulate transepithelial permeability in a pertussis toxin sensitive manner. MPDZ, along with Kir4.2, may form a complex with other proteins in the nephron and regulate ion transport. MPDZ contains one L27 domain and thirteen PDZ domains.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10722R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10722R-CY5
Lokale Artikelnummer::
BOSSBS-10722R-CY5
Beschreibung:
Staphylococcal enterotoxins represent a group of proteins, which are secreted by Staphylococcus aureus and cause staphylococcal food poisoning syndrome. The illness is characterised by high fever, hypotension, diarrhea, shock, and in some cases death. Their molecular masses range between 27 and 30 kDa. At present, seven enterotoxins are known, namely A, B, C1, C2, C3, D and E. Their amino acid sequences have been determined and it was shown that all are single chain polypeptides containing one disulfide bond formed by two half cystines located in the middle of the polypeptide chain, which form the so called cysteine loop. SEB is an extremely potent activator of T cells, stimulating the production and secretion of various cytokines which mediate many of the toxic effects of SEB.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9138R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9138R-CY5
Lokale Artikelnummer::
BOSSBS-9138R-CY5
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZSWIM3 (Zinc finger SWIM domain-containing protein 3) is a 696 amino acid protein that contains one SWIM-type zinc finger. SWIM domains are found in a variety of eukaryotic and prokaryotic proteins and are thought to be critical for certain ubiquitination reactions. The gene encoding ZSWIM3 maps to human chromosome 20, which contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7418R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7418R-CY5.5
Lokale Artikelnummer::
BOSSBS-7418R-CY5.5
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC20 (zinc finger, DHHC-type containing 20) is a 365 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger and is thought to function as a palmitoyltransferase, catalyzing the transformation of palmitoyl-CoA and a cysteine-conjugated protein to an S-palmitoyl protein and free CoA. In response to DNA damage, ZDHHC20, which exists as multiple alternatively spliced isoforms, may be phosphorylated by ATM or ATR. The gene encoding ZDHHC20 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9140R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9140R
Lokale Artikelnummer::
BOSSBS-9140R
Beschreibung:
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12372R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12372R
Lokale Artikelnummer::
BOSSBS-12372R
Beschreibung:
MEGF10 is a 1,140 amino acid protein encoded by the human gene MEGF10. MEGF10 belongs to the MEGF family and contains fifteen EGF-like domains and one EMI domain. The engulfment of dying cells is a specialized form of phagocytosis that is highly conserved across evolution and is mediated by the concerted action of several molecules. MEGF10 is an engulfment receptor protein that localizes to the plasma membrane in a punctuated pattern. The MEGF10 protein shares structural similarities with nematode engulfment receptor cell death abnormal-1 (CED-1). MEGF10 function is modulated by the ATP binding cassette transporter ABCA1, which is an ortholog to CED-7. It is expressed at the cell surface in clusters around cell corpses during engulfment, and during the engulfment of apoptotic thymocytes is recruited to the bottom of the forming phagocytic cup.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4728R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4728R-CY3
Lokale Artikelnummer::
BOSSBS-4728R-CY3
Beschreibung:
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11913R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11913R-CY7
Lokale Artikelnummer::
BOSSBS-11913R-CY7
Beschreibung:
NPDC-1 (Neural Proliferation Differentiation and Control-1) is expressed in neurons once they have stopped dividing and begun to differentiate. NPDC-1 is transported from the Golgi apparatus via vesicles before becoming internalized by endosomes at the cell membrane. NPDC-1 interacts with Cdk2, D-type cyclins, and the transcription factor E2F1. This interaction can lead to an increased replication time, and might have implications in final neural differentiation and apoptosis. NPDC-1 has been shown to colocalize with synaptic vesicle proteins: synaptophysin, synaptobrevin 2, and Rab3 GEP (Rab3 GTP/GDP exchange protein). One function of NPDC-1 is to regulate retinoic acid-mediated events by directly interacting with retinoid receptors. The amino acid sequence of NPDC-1 is highly conserved between mouse, rat, and human.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7595R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7595R
Lokale Artikelnummer::
BOSSBS-7595R
Beschreibung:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12372R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12372R-CY3
Lokale Artikelnummer::
BOSSBS-12372R-CY3
Beschreibung:
MEGF10 is a 1,140 amino acid protein encoded by the human gene MEGF10. MEGF10 belongs to the MEGF family and contains fifteen EGF-like domains and one EMI domain. The engulfment of dying cells is a specialized form of phagocytosis that is highly conserved across evolution and is mediated by the concerted action of several molecules. MEGF10 is an engulfment receptor protein that localizes to the plasma membrane in a punctuated pattern. The MEGF10 protein shares structural similarities with nematode engulfment receptor cell death abnormal-1 (CED-1). MEGF10 function is modulated by the ATP binding cassette transporter ABCA1, which is an ortholog to CED-7. It is expressed at the cell surface in clusters around cell corpses during engulfment, and during the engulfment of apoptotic thymocytes is recruited to the bottom of the forming phagocytic cup.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4728R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4728R
Lokale Artikelnummer::
BOSSBS-4728R
Beschreibung:
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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