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3-Formyl-1H-indazole-5-carboxylic+acid
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3-Formyl-1H-indazole-5-carboxylic+acid
Artikel-Nr:
(WITGDH.WHM121602)
Lieferant:
WITEG LABORTECHNIK
Hersteller-Artikelnummer::
DH.WHM121602
Lokale Artikelnummer::
WITGDH.WHM121602
Beschreibung:
Heating Mantles with stirrer WHM, for beakers 250 ml, w. integrated power controller, temperature range 450C, 140 W, power supply 230 V 1 * 1 ST
VE:
1 * 1 ST
Artikel-Nr:
(SERVDNAISOLATION)
Lieferant:
SERVICE RELATED ITEMS
Hersteller-Artikelnummer::
DNAISOLATION
Lokale Artikelnummer::
SERVDNAISOLATION
Beschreibung:
DNA preparation, QC-testing (real-time PCR) and shipment of 50 l DNA sample for use as positive control in real-time PCR 1 * 1 ST
VE:
1 * 1 ST
Artikel-Nr:
(WITGDH.WHM121605)
Lieferant:
WITEG LABORTECHNIK
Hersteller-Artikelnummer::
DH.WHM121605
Lokale Artikelnummer::
WITGDH.WHM121605
Beschreibung:
Heating Mantles with stirrer WHM, for beakers 600 ml, w. integrated power controller, temperature range 450C, 240 W, power supply 230 V 1 * 1 ST
VE:
1 * 1 ST
Artikel-Nr:
(SYST2000)
Lieferant:
Systec GmbH
Hersteller-Artikelnummer::
2000
Lokale Artikelnummer::
SYST2000
Beschreibung:
electronic controlled multifunction peristaltic pump. For precise dosing of liquids (0,1 - 99999,9ml). Including flex stand, foot switch and two sets of hoses 1 * 1 ST
VE:
1 * 1 ST
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(MSPPDC-0-500)
Lieferant:
MARKET SOURCE PART PROCESS
Hersteller-Artikelnummer::
DC-0-500
Lokale Artikelnummer::
MSPPDC-0-500
Beschreibung:
Density control kit : complementary Anchor strand 1 and complementary Anchor strand Concentration: 200 nM Volume: 2 x 500 l cAncho r1 and 2 x 500 l cAnchor2 1 * 1 ST
VE:
1 * 1 ST
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(VACU22614242)
Lieferant:
VACUUBRAND
Hersteller-Artikelnummer::
22614242
Lokale Artikelnummer::
VACU22614242
Beschreibung:
Chemie-Pumpstand PC 3002 VARIO EKP o. C. ohne Controller, mit Emissionskondensator Peltronic, 200-230 V/50-60 Hz, ohne Netzkabel 1 * 1 ST
VE:
1 * 1 ST
Artikel-Nr:
(MSPPB07HQKVDNF)
Lieferant:
MARKET SOURCE PART PROCESS
Hersteller-Artikelnummer::
B07HQKVDNF
Lokale Artikelnummer::
MSPPB07HQKVDNF
Beschreibung:
Queta LED digital alarm clock small grandfather clock with date temperature display, 3 adjustable brightness, voice control, 2 modes display (brown) 1 * 1 ST
VE:
1 * 1 ST
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(MSPPB00IUDO89I)
Lieferant:
MARKET SOURCE PART PROCESS
Hersteller-Artikelnummer::
B00IUDO89I
Lokale Artikelnummer::
MSPPB00IUDO89I
Beschreibung:
Lucci Air Airfusion Climate II DC 127cm Brushed Chrome 6 Speeds ECO-DC Motor Energy Saving Remote Control [Energy Class A] 1 * 1 ST
VE:
1 * 1 ST
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(WITGDH.WHM12096)
Lieferant:
WITEG LABORTECHNIK
Hersteller-Artikelnummer::
DH.WHM12096
Lokale Artikelnummer::
WITGDH.WHM12096
Beschreibung:
Heating Mantles WHM, f. round bottom flasks 3000 ml, without integrated power controller, temp. range 650C, 700 W, power supply 230 V 1 * 1 ST
VE:
1 * 1 ST
Artikel-Nr:
(VACU20737524)
Lieferant:
VACUUBRAND
Hersteller-Artikelnummer::
20737524
Lokale Artikelnummer::
VACU20737524
Beschreibung:
Chemie-Pumpenstand PC 3004 VARIO EKP o. C. ohne Controller, mit elektr. Emissionskondens. Pelltronic, 200-230 V/50-60 Hz ohne Netzkabel 1 * 1 ST
VE:
1 * 1 ST
Artikel-Nr:
(MSPP290124)
Lieferant:
MARKET SOURCE PART PROCESS
Hersteller-Artikelnummer::
290124
Lokale Artikelnummer::
MSPP290124
Beschreibung:
Q. Station 101 1 Pieces 2,420.00 2,420.00 High-performance controller for highly data rates: 8 Measuring channels (2 channels per RS -485) 100 khz 1 * 1 ST
VE:
1 * 1 ST
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(FRIT24.4200.00)
Lieferant:
FRITSCH
Hersteller-Artikelnummer::
24.4200.00
Lokale Artikelnummer::
FRIT24.4200.00
Beschreibung:
Vibratory Feeder LABORETTE 24 with V-shaped channel incl. connection cable for automatic control via the Variable Speed Rotor Mill PULVERISETTE 14 premium line null
VE:
Artikel-Nr:
(MSPPB06XZYP5FW)
Lieferant:
MARKET SOURCE PART PROCESS
Hersteller-Artikelnummer::
B06XZYP5FW
Lokale Artikelnummer::
MSPPB06XZYP5FW
Beschreibung:
ThermoPro TP55 Digital Thermo-Hygrometer, Indoor Thermometer, Hygrometer, Temperature and Humidity Meter with Indoor Climate Indicat or for Indoor Climate Control, Room Air Dissipation Monitoring 1 * 1 ST
VE:
1 * 1 ST
This is a MarketSource item. Additional charges may apply
Lieferant:
VWR Collection
Beschreibung:
Filter manifold seal, Powerpette®, Für: Powerpette®
Artikel-Nr:
(NOVUNBP2-34287-0.1)
Lieferant:
Novus Biologicals
Hersteller-Artikelnummer::
NBP2-34287-0.1
Lokale Artikelnummer::
NOVUNBP2-34287-0.1
Beschreibung:
CD45, also known as leukocyte common antigen (LCA), T200, or Ly5, is a member C of the class 1 receptor-like protein tyrosine phosphatase (PTPRC) family (1, 2). It is a transmembrane glycoprotein which, due to alternative splicing, has a multiple isoforms with a theoretical molecular weight ranging from 180 - 220 kDa (1, 3-5). Human CD45 is synthesized as a 1281 amino acid sequence consisting of an alternatively spliced extracellular receptor-like region, a cysteine-rich domain, fibronectin-like III repeats, a transmembrane segment, and a cytoplasmic region with tandem protein tyrosine phosphatase (PTP) domains: the membrane proximal domain (D1) and the membrane distal domain (D2) (3, 5). CD45 is expressed on all nucleated hematopoietic cells and their precursors, except mature red blood cells, and is one of the most abundantly-expressed cell-surface glycoproteins, comprising approximately 10% of surface proteins in lymphocytes (3). Functionally, CD45 is essential for development and activation of T-cells and B-cells (1-5). More specifically, CD45 positively regulates antigen receptor signaling and Src-family member kinase activity (1, 3). There are many ways to regulate CD45 phosphatase activity including ligand binding, dimerization, protein interactions, cellular localization, and covalent modifications (3, 6). Ligands for CD45 include pUL11, a transmembrane protein of the cytomegalovirus RL11 (CMV RL11) family, and placental protein 14 (PP14), both of which exclusively bind CD45, and various lectins including CD22, galectin-1, galectin-3, macrophage mannose receptor (MR), and macrophage galactose-type lectin (MGL) (6).
Given its role in immune cell development and activation, CD45 has also been linked to a variety of diseases. The importance of CD45 in immunity has been revealed in human and mouse studies where CD45-deficiency leads to a severe-combined immunodeficiency (SCID) phenotype (2, 3, 6). A CD45-knockout mice study revealed inhibited thymocyte production and poor B-cell response, whereas CD45 activation in mice causes lymphoproliferation and autoantibody production (3). CD45 variants have been associated with altered immune function and autoimmune disorders including multiple sclerosis, systemic lupus erythematosus (SLE), and rheumatoid arthritis (6). Furthermore, altered CD45 expression has been implicated in oncological conditions including chronic lymphatic leukemia, acute lymphatic leukemia, Hodgkin lymphoma, multiple myeloma, and diffuse large B-cell lymphoma (6). Considering its role in autoimmune disorders, immunodeficiency and cancer, CD45 is an ideal therapeutic target (3, 6). The main approaches to control CD45 function is through either selective inhibitors or anti-CD45 antibodies (3). Alternative names for CD45 includes B220, CD antigen: CD45, CD45 antigen, CD45R, EC 3.1.3.48, GP180, LCA, Leukocyte common antigen, LY5, protein tyrosine phosphatase receptor type c polypeptide, PTPRC, receptor-type tyrosine-protein phosphatase C, T200 Glycoprotein, and T200. References 1. Trowbridge, I. S., & Thomas, M. L. (1994). CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annual review of immunology. https://doi.org/10.1146/annurev.iy.12.040194.000505 2. Andersen, J. N., Jansen, P. G., Echwald, S. M., Mortensen, O. H., Fukada, T., Del Vecchio, R., Tonks, N. K., & Moller, N. P. (2004). A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 3. Hermiston, M. L., Xu, Z., & Weiss, A. (2003). CD45: a critical regulator of signaling thresholds in immune cells. Annual review of immunology. https://doi.org/10.1146/annurev.immunol.21.120601.140946 4. Tonks, N. K., Diltz, C. D., & Fischer, E. H. (1990). CD45, an integral membrane protein tyrosine phosphatase. Characterization of enzyme activity. The Journal of biological chemistry. 5. Nam, H. J., Poy, F., Saito, H., & Frederick, C. A. (2005). Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45. The Journal of experimental medicine. https://doi.org/10.1084/jem.20041890 6. Rheinlander, A., Schraven, B., & Bommhardt, U. (2018). CD45 in human physiology and clinical medicine. Immunology letters. https://doi.org/10.1016/j.imlet.2018.01.009
VE:
1 * 0,1 mg
Artikel-Nr:
(MSPPBPVADVP50SZ04)
Lieferant:
MARKET SOURCE PART PROCESS
Hersteller-Artikelnummer::
BPVADVP50SZ04
Lokale Artikelnummer::
MSPPBPVADVP50SZ04
Beschreibung:
Carten BPV Series Large Pneumatic Pinch Valve, Control Version with elcropneumatic positioner, provided with insert kit to suit 1/2 x 4/5 tubing, and skid wall mounting bracket (BP50-VL410) 1 * 1 ST
VE:
1 * 1 ST
This is a MarketSource item. Additional charges may apply
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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