Suche >
3-(2-Fluorophenyl)-1H-pyrazole
Drucken
Sie suchten nach:
24 112 results were found
3-(2-Fluorophenyl)-1H-pyrazole
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Oncostatin M is a cytokine that is produced by macrophages, dendritic cells, and T lymphocytes during inflammatory events. The Type-I and Type-II Oncostatin M receptors are located on the cell surface of endothelial and tumor cells, contain the glycoprotein 130 (gp130) subunit, and activate the JAK/STAT signaling pathway. Oncostatin M functions to inhibit tumor cell proliferation, induce liver stem cell maturation, regulate cytokine production during hematopoiesis and inflammation, stimulate bone formation, and promote nervous system development.
Artikel-Nr:
(PRSI91-016)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-016
Lokale Artikelnummer::
PRSI91-016
Beschreibung:
Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI25-010)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-010
Lokale Artikelnummer::
PRSI25-010
Beschreibung:
SNAPc is involved in transcription by two types of polymerases; it is required for transcription of both the RNA polymerase II and III small-nuclear RNA genes and binds specifically to the proximal sequence element PSE, a non-TATA-box basal promoter element common to these two types of genes. In addition, SNAPc is composed of at least three TAFs, SNAP43, SNAP45 and SNAP50.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI77-010)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
77-010
Lokale Artikelnummer::
PRSI77-010
Beschreibung:
The LN3 monoclonal antibody specifically reacts with the human leukocyte antigen-DR (HLA-DR), a MHC class II heterodimeric surface glycoprotein. HLA-DR is expressed on the antigen presenting surfaces of monocytes, macrophages, dendritic cells, activated T cells, and B cells. It is integral to peptide presentation to CD4+ T cells.
VE:
1 * 100 Tests
New Product
Artikel-Nr:
(PRSI76-826)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-826
Lokale Artikelnummer::
PRSI76-826
Beschreibung:
The H1.2F3 monoclonal antibody specifically reacts with human CD69, the 27 to 33 kDa type II transmembrane protein also known as the very early activation antigen (VEA) or the activation inducer molecule (AIM). It is expressed as a disulfide-linked dimer on B cells, T cells, NK cells, platelets, eosinophils, and neutrophils. It increases in expression upon cell activation and seems to serve a role as a signaling receptor.
VE:
1 * 0,1 mg
New Product
Artikel-Nr:
(SPCME1040-500GM)
Lieferant:
Spectrum Chemical
Hersteller-Artikelnummer::
E1040-500GM
Lokale Artikelnummer::
SPCME1040-500GM
Beschreibung:
(Ethylenedinitrilo)tetraacetic Acid, Powder, Reagent, ACS, is generally abbreviated as EDTA, a colorless, water soluble aminopolycarboxylic acid and solid. It is used by many industries and in the laboratory for applications ranging from a sequestering agent to chelation therapy. As an ACS grade Reagent, this Spectrum Chemical manufactured compound is used as the quality standard against which other substances are graded and has met the toughest regulatory standards for quality and pureness.
VE:
1 * 500 g
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Interferon gamma (IFN-γ) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-γ is produced by T cells and natural killer cells following antigen-specific activation. IFN-γ binds IFN-γ receptors (IFN-γ R1 and IFN-γ R2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFN-γ-induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. Mouse IFN-γ is not cross-reactive with human IFN-γ.
Artikel-Nr:
(PRSI91-012)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-012
Lokale Artikelnummer::
PRSI91-012
Beschreibung:
IFN gamma is the major interferon produced by mitogenically or antigenically stimulated lymphocytes. It is structurally different from type I interferon and its major activity is immunoregulation. It has been implicated in the expression of class II histocompatibility antigens in cells that do not normally produce them, leading to autoimmune disease. Interferon gamma is produced mainly byT-cells and natural killer cells activated by antigens, mitogens, or alloantigens. It is produced by lymphocytes expressing the surface antigens CD4 and CD8. IFN gamma synthesis is induced by IL-2, FGF-basic, and EGF.
VE:
1 * 50 µG
Artikel-Nr:
(253300-10)
Lieferant:
Merck Millipore (Calbiochem)
Hersteller-Artikelnummer::
253300-10
Lokale Artikelnummer::
CALB253300-10
Beschreibung:
Deltamethrin is a synthetic type II pyrethroid that acts as a potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 100 pM). Also have varied effects on ion channels. Causes an increase in neurotransmitter release at synapses, and increases intrasynaptosomal Ca<sup>2+</sup> levels.
VE:
1 * 10 mg
Artikel-Nr:
(PRSI91-407)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-407
Lokale Artikelnummer::
PRSI91-407
Beschreibung:
Chitotriosidase-1 (CHIT1) is a glycoprotein that belongs to the Glycosyl Hydrolase 18 family and Chitinase class II subfamily. It is secreted by cultured macrophages and serves to degrade chitin, chitotriose and chitobiose. CHIT1 may participate in the defense against nematodes and other pathogens. It is highly expressed in the plasma of patients with Gaucher's disease type I, which can be used as diagnostic aid and to evaluate the success of treatment that brings levels back to normal. The amino acid sequence of human CHIT1 is 99%, 76%, 75% and 55% identical to that of chimpansee, rat, mouse and fruit fly, respectively.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI76-935)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-935
Lokale Artikelnummer::
PRSI76-935
Beschreibung:
The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand. CD178 is a TNF superfamily type II transmembrane glycoprotein expressed by activated T and NK cells and is involved in Fas-mediated apoptosis of lymphocytes. CD178 is also expressed by monocytes, neutrophils, granulocytes and the parenchymal cells of the retina and cornea. The NOK-1 antibody has been reported to bind to COOH-terminus of the Fas ligand in the region associated with Fas binding.
VE:
1 * 0,1 mg
New Product
Artikel-Nr:
(PRSI76-817)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-817
Lokale Artikelnummer::
PRSI76-817
Beschreibung:
The H1.2F3 monoclonal antibody specifically reacts with human CD69, the 27 to 33 kDa type II transmembrane protein also known as the very early activation antigen (VEA) or the activation inducer molecule (AIM). It is expressed as a disulfide-linked dimer on B cells, T cells, NK cells, platelets, eosinophils, and neutrophils. It increases in expression upon cell activation and seems to serve a role as a signaling receptor.
VE:
1 * 0,1 mg
New Product
Artikel-Nr:
(PRSI92-428)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-428
Lokale Artikelnummer::
PRSI92-428
Beschreibung:
Kell blood group glycoprotein (KEL) is a single-pass type II membrane protein which belongs to the peptidase M13 family. It is expressed in Expressed at high levels in erythrocytes and testis, and, at lower levels, in skeletal muscle, tonsils, lymph node, spleen and appendix. KEL has been shown zinc endopeptidase with endothelin-3-converting enzyme activity. It cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. It links via a single disulfide bond to the XK membrane protein that carries the Kx antigen.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-318)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-318
Lokale Artikelnummer::
PRSI90-318
Beschreibung:
Dectin-1 and dectin-2 are type II transmembrane proteins of the C-type lectin family. They contain single carbohydrate recognition domains (CRDs) in their extracellular region. Dectin-1 and dectin-2 are expressed in macrophages and dendritic cells. Dectin-1 recognises beta-glucans with its CRD and signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domain, whereas dectin-2 recognises alpha-mannans and transduces its signal through association with the ITAM-containing Fc receptor gamma-chain.
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-4114R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4114R-A488
Lokale Artikelnummer::
BOSSBS-4114R-A488
Beschreibung:
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4114R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4114R-A555
Lokale Artikelnummer::
BOSSBS-4114R-A555
Beschreibung:
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
VE:
1 * 100 µl
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
Dieses Produkt ist nicht mehr verfügbar. Bitte kontaktieren Sie den VWR Kundenservice.
|
|||||||||
Listenansicht
