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4-Methyl-2-(1-pyrrolidinyl)pentanoic+acid
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4-Methyl-2-(1-pyrrolidinyl)pentanoic+acid
Lieferant:
Alfa Aesar
Beschreibung:
N-Methylpropylamin 97%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-Nitro-m-kresol
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Benzoinmethylether 96%
Artikel-Nr:
(APOSOR11947-250MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR11947-250MG
Lokale Artikelnummer::
APOSOR11947-250MG
Beschreibung:
Methylimidazo[1,2-a]pyridin-6-carboxylat Hydrochlorid
VE:
1 * 250 mg
Artikel-Nr:
(BOSSBS-5915R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5915R-A488
Lokale Artikelnummer::
BOSSBS-5915R-A488
Beschreibung:
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5915R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5915R-A350
Lokale Artikelnummer::
BOSSBS-5915R-A350
Beschreibung:
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
3-Methylxanthin
Artikel-Nr:
(BLDPBD137127-1G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD137127-1G
Lokale Artikelnummer::
BLDPBD137127-1G
Beschreibung:
Maltol propionate 97%
VE:
1 * 1 g
Lieferant:
Alfa Aesar
Beschreibung:
4-Nitro-m-toluonitril ≥97%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
(2-Methoxyethoxy)methylchlorid, technische Qualität
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
N-(4-Aminobenzyl)-N-methylamine 95+%
Artikel-Nr:
(BOSSBS-13025R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13025R-A555
Lokale Artikelnummer::
BOSSBS-13025R-A555
Beschreibung:
Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13025R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13025R-A647
Lokale Artikelnummer::
BOSSBS-13025R-A647
Beschreibung:
Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0497R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0497R-A350
Lokale Artikelnummer::
BOSSBS-0497R-A350
Beschreibung:
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0497R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0497R-A555
Lokale Artikelnummer::
BOSSBS-0497R-A555
Beschreibung:
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0497R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0497R-CY3
Lokale Artikelnummer::
BOSSBS-0497R-CY3
Beschreibung:
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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