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5,5'-Dibrom-2,2'-bithiophen
Lieferant:
Biotium
Beschreibung:
Recognizes a protein of 55 kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.This MAb was characterized as human CD4 antibody at II and IV International Workshop on Human Leukocyte Differentiation Antigens.
Lieferant:
Biotium
Beschreibung:
Recognizes a protein of 55 kDa, identified as CD25. It is expressed on activated T- and B-cells and activated monocytes/macrophages. With respect to lymphomas, CD25 is present on malignant cells of Hodgkin's disease, HTLV-1 adult T-cell leukemia, cutaneous T-cell lymphoma, and hair cell leukemia. Increased levels of soluble CD25 are observed in the leukemias/lymphomas and inflammatory/ autoimmune diseases. CD25 molecule alone appears to function as a low affinity receptor and associates with CD122 (IL-2R chain, p75) and CD132 (common chain) to form the high affinity IL-2 receptor complex. CD25 antibodies detect three epitope regions, A, B and C. This MAb recognizes the epitope B, which is located at residue 3-104 of CD25 and doe not block IL-2 binding to CD25.
Artikel-Nr:
(BOSSBS-9035R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9035R-A555
Lokale Artikelnummer::
BOSSBS-9035R-A555
Beschreibung:
Pyridoxal kinase belongs to the pyridoxine kinase family and phosphorylates vitamin B6, a step necessary for the conversion of vitamin B6 to pyridoxal 5’ phosphate (PLP), the active form of vitamin B6. PLP acts as a coenzyme and functions to maintain homeostasis. Pyridoxal kinase is a 312-amino acid cytoplasmic protein that may act as a homodimer and is expressed ubiquitously. There are three known isoforms of pyridoxal kinase, and isoform 3 expression is observed in adult testis and spermatozoa. The optimum pH for pyridoxal kinase is between 5.5 and 6.0. PDXK, the gene that encodes the pyridoxal kinase protein, maps to chromosome 21q22.3 and may be a candidate gene for autoimmune polyglandular disease type 1, a genetic disorder that has been mapped to the same region on chromosome 21.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
Recognizes a protein of 55 kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.This MAb was characterized as human CD4 antibody at II and IV International Workshop on Human Leukocyte Differentiation Antigens.
Artikel-Nr:
(40-0801-U100)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
40-0801-U100
Lokale Artikelnummer::
TNBO40-0801-U100
Beschreibung:
The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-12976R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12976R-CY5
Lokale Artikelnummer::
BOSSBS-12976R-CY5
Beschreibung:
Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.
VE:
1 * 100 µl
Artikel-Nr:
(BNUM1076-50)
Lieferant:
Biotium
Hersteller-Artikelnummer::
BNUM1076-50
Lokale Artikelnummer::
BTIUBNUM1076-50
Beschreibung:
This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67 kDa (CK1); 64 kDa (CK3); 59 kDa (CK4); 58 kDa (CK5); 56 kDa (CK6); 52 kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50 , 48, 46, 45, and 40 kDa. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
VE:
1 * 50 µl
Lieferant:
Tonbo Biosciences
Beschreibung:
The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.
Lieferant:
Tonbo Biosciences
Beschreibung:
The BC96 antibody is specific for human CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Signaling via CD25 may modulate Th17 and Treg cell differentiation, and has been shown to play a role in the function of dendritic cells.
Artikel-Nr:
(BOSSBS-10059R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10059R-A750
Lokale Artikelnummer::
BOSSBS-10059R-A750
Beschreibung:
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
VE:
1 * 100 µl
Artikel-Nr:
(92315.010)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC92315.010
Beschreibung:
Organic Standard, 6-Methoxy-2,2',3,3',4,5,5',6'-octabromodiphenyl ether, 50 µg/ml in acetonitrile, Packung: Glass ampoule/vial
VE:
1 * 1 mL
Artikel-Nr:
(BLDPBD491672-1G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD491672-1G
Lokale Artikelnummer::
BLDPBD491672-1G
Beschreibung:
(S)-3,3'-Bis(4-nitrophenyl)-1,1'-binapthyl-2,2'-diyl hydrogenphosphate 98% 99%ee
VE:
1 * 1 g
Lieferant:
Sigma-Aldrich
Beschreibung:
3,3′,5,5′-Tetramethylbenzidine (TMB) is a noncarcinogenic substitute (Ames test negative) for benzidine suitable as peroxidase substrate for use in ELISA procedures.
Artikel-Nr:
(APOSOR17915-5G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR17915-5G
Lokale Artikelnummer::
APOSOR17915-5G
Beschreibung:
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]furan
VE:
1 * 5 g
Artikel-Nr:
(BOHLR1355-20)
Lieferant:
Bohlender
Hersteller-Artikelnummer::
R1355-20
Lokale Artikelnummer::
BOHLR1355-20
Beschreibung:
Mit b.safe System Waste Caps können b.safe Waste Tubes am Kanister angeschlossen und Lösemittabfälle sicher gesammelt werden. Vermeiden überlaufender Kanister durch Anschluss der Waste Cap an ein b.safe Display zur elektronischen Füllstandskontrolle. Die zusätzliche Vorwarnung ermöglicht es dem Anwender die Bereitstellung von Wechselbehältern für große Abfallmengen z.B. vor Feierabend oder am Wochenende. Zuverlässige Überwachung der Füllstände von Abfallkanistern in Laborschränken und Werkbänken. Über b.safe Waste Tubes werden Lösemittelabfälle direkt in den Kanister eingeleitet, Lösemitteldämpfe aus der beim Befüllen entweichenden Luft werden durch den Abluftfilter mit Aktivkohlefüllung zurückgehalten oder einen Entlüftungsschlauch in den Abzug abgeführt.
VE:
1 * 1 ST
Lieferant:
Tonbo Biosciences
Beschreibung:
The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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