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ELBE WERKSTATTEN
Artikel-Nr:
(BOSSBS-10138R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10138R-A680
Lokale Artikelnummer::
BOSSBS-10138R-A680
Beschreibung:
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional Signalling into neighboring cells. The Signalling pathway downstream of the receptor is referred to as forward Signalling while the Signalling pathway downstream of the ephrin ligand is referred to as reverse Signalling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK Signalling cascades to regulate cell migration and adhesion respectively.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
Methylgrün-Zinkchlorid-Doppelsalz, rein, zertifiziert
Artikel-Nr:
(BOSSBS-3751R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3751R-CY3
Lokale Artikelnummer::
BOSSBS-3751R-CY3
Beschreibung:
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4207R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4207R
Lokale Artikelnummer::
BOSSBS-4207R
Beschreibung:
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10030R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10030R-CY7
Lokale Artikelnummer::
BOSSBS-10030R-CY7
Beschreibung:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1922R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1922R-CY5.5
Lokale Artikelnummer::
BOSSBS-1922R-CY5.5
Beschreibung:
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
VE:
1 * 100 µl
Artikel-Nr:
(H66446.03)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
H66446.03
Lokale Artikelnummer::
ALFAH66446.03
Beschreibung:
Dde-Lys(Fmoc)-OH 98%
VE:
1 * 1 g
Lieferant:
Alfa Aesar
Beschreibung:
2-(1,3-Dioxolan-2-yl)ethylboronsäurepinakolester ≥97%
Lieferant:
Alfa Aesar
Beschreibung:
4-Ethylmorpholin ≥98%
Artikel-Nr:
(EPPE5825718.003)
Lieferant:
EPPENDORF
Hersteller-Artikelnummer::
5825718.003
Lokale Artikelnummer::
EPPE5825718.003
Beschreibung:
SBS-Adapter, für 1 Platte mit Rahmen im SBS-Format, 2 Stück, Für: Eppendorf 5804 / 5804 R / 5810 / 5810 R, Tisch-Zentrifuge
VE:
1 * 2 ST
Lieferant:
Alfa Aesar
Beschreibung:
Nalidixinsäure ≥99%
Lieferant:
GREINER BIO ONE
Beschreibung:
PP, non-sterile, without lid. The use of the 96-well format allows the scale up of basic PCR work, while the 384-well format is ideal for high throughput screening projects, such as the sequencing of complex genomes.
Artikel-Nr:
(BLDPBD37415-1G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD37415-1G
Lokale Artikelnummer::
BLDPBD37415-1G
Beschreibung:
3-[2-(2-Ethoxycarbonyl-ethoxy)-ethoxy]-propionic acid 97%
VE:
1 * 1 g
Artikel-Nr:
(PRSI30-310)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
30-310
Lokale Artikelnummer::
PRSI30-310
Beschreibung:
IRX1 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.IRX1 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.
VE:
1 * 100 µG
Lieferant:
Alfa Aesar
Beschreibung:
1,1,1-Tris(hydroxymethyl)propan ≥98%
Lieferant:
Serva
Beschreibung:
For cerebrospinal fluid (CSF) analysis by isoelectric focusing.
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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